Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator

Cavalli, Giacomo; Paro, Renato

doi:10.1126/science.286.5441.955

Cited by 232 publications

(159 citation statements)

References 21 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…Trx is present in the TAC1 complex that contains the histone acetyltransferase dCBP (13). The role of histone acetylation in PcG/TrxG-dependent processes is supported by the observation that disruption of PRE-mediated silencing in Drosophila transgenes is accompanied by local accumulation of hyperacetylated histone H4 (17). Currently it is unclear how the interplay between DNA elements, histones and their modifications, and the PcG/TrxG-chromatinassociated proteins results in a stable gene expression state, which is heritable through DNA replication and mitosis.…”

mentioning

confidence: 74%

Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins

Beisel

Buneß

Roustan-Espinosa

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

mentioning

confidence: 74%

Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins

Beisel

Buneß

Roustan-Espinosa

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

“…TRX and other Trithorax Group (TrxG) proteins antagonize Polycomb silencing and are required for robust maintenance of active transcriptional states of Polycomb target genes (22)(23)(24)(25). TRX itself is a histone methyltransferase that specifically trimethylates histone H3 on lysine 4 (H3K4me3), a modification associated with promoter regions of active genes (26)(27)(28)(29)(30).…”

Section: Resultsmentioning

confidence: 99%

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

Siebold¹,

Banerjee²,

Tie³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

174

149

View full text Add to dashboard Cite

Polycomb Group (PcG) and Trithorax Group (TrxG) proteins are key epigenetic regulators of global transcription programs. Their antagonistic chromatin-modifying activities modulate the expression of many genes and affect many biological processes. Here we report that heterozygous mutations in two core subunits of Polycomb Repressive Complex 2 (PRC2), the histone H3 lysine 27 (H3K27)-specific methyltransferase E(Z) and its partner, the H3 binding protein ESC, increase longevity and reduce adult levels of trimethylated H3K27 (H3K27me3). Mutations in trithorax (trx), a well known antagonist of Polycomb silencing, elevate the H3K27me3 level of E(z) mutants and suppress their increased longevity. Like many long-lived mutants, E(z) and esc mutants exhibit increased resistance to oxidative stress and starvation, and these phenotypes are also suppressed by trx mutations. This suppression strongly suggests that both the longevity and stress resistance phenotypes of PRC2 mutants are specifically due to their reduced levels of H3K27me3 and the consequent perturbation of Polycomb silencing. Consistent with this, long-lived E(z) mutants exhibit derepression of Abd-B, a well-characterized direct target of Polycomb silencing, and Odc1, a putative direct target implicated in stress resistance. These findings establish a role for PRC2 and TRX in the modulation of organismal longevity and stress resistance and indicate that moderate perturbation of Polycomb silencing can increase longevity.aging | epigenetics | histone methyltransferase | Polycomb silencing

show abstract

“…For instance, studies in plants demonstrated that altered patterns of DNA methylation (so-called epialleles) can be inherited over successive generations [7], [8]. Transmission of the chromatin state of a chromosomal regulatory element through both mitosis and meiosis has been shown in Drosophila [9], [10]. In zebrafish embryos, homeostatic and developmentally regulated genes are marked by permissive and repressive histone modifications prior to zygotic genome activation.…”

Section: Introductionmentioning

confidence: 99%

Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming?

Gill

Erkek

Peters

2012

Current Opinion in Cell Biology

View full text Add to dashboard Cite

At fertilization, fusion of two differentiated gametes forms the zygote that is capable of forming all of the varied cell lineages of an organism. It is widely thought that the acquisition of totipotency involves extensive epigenetic reprogramming of the germline state into an embryonic state. However, recent data argue that this reprogramming is incomplete and that substantial epigenetic information passes from one generation to the next. In this review we summarize the changes in chromatin states that take place during mammalian gametogenesis and examine the evidence that early mammalian embryogenesis may be affected by inheritance of epigenetic information from the parental generation.

show abstract

Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator

Cited by 232 publications

References 21 publications

Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins

Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming?

Contact Info

Product

Resources

About