Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation

Kang, Mo K.; Mehrazarin, Shebli; Park, No‐Hee; Wang, Cun‐Yu

doi:10.1111/odi.12569

Cited by 43 publications

(35 citation statements)

References 120 publications

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“…This impedes the silencing activity of the PcG proteins and leads to target gene expression. Figure is revised from Kang et al (2017). human dental pulp cells (HDP) and animal models.…”

Section: Mechanisms Of Epigenetic Gene Regulation: Example Of Kdm6b Amentioning

confidence: 99%

Genetic and Epigenetic Characterization of Pulpal and Periapical Inflammation

et al. 2020

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Pulpal and periapical diseases affect a large segment of the population. The role of microbial infections and host effector molecules in these diseases is well established. However, the interaction between host genes and environmental factors in disease susceptibility and progression is less well understood. Studies of genetic polymorphisms in disease relevant genes have suggested that individual predisposition may contribute to susceptibility to pulpal and periapical diseases. Other studies have explored the contribution of epigenetic mechanisms to these diseases. Ongoing research expands the spectrum of non-coding RNAs in pulpal disease to include viral microRNAs as well. This review summarizes recent advances in the genetic and epigenetic characterization of pulpal and periapical disease, with special emphasis on recent data that address the pathogenesis of irreversible pulpal pathosis and apical periodontitis. Specifically, proinflammatory and anti-inflammatory gene expression and gene polymorphism, as well as recent data on DNA methylation and microRNAs are reviewed. Improved understanding of these mechanisms may aid in disease prevention as well as in improved treatment outcomes.

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“…This impedes the silencing activity of the PcG proteins and leads to target gene expression. Figure is revised from Kang et al (2017). human dental pulp cells (HDP) and animal models.…”

Section: Mechanisms Of Epigenetic Gene Regulation: Example Of Kdm6b Amentioning

confidence: 99%

Genetic and Epigenetic Characterization of Pulpal and Periapical Inflammation

et al. 2020

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“…To date, more than 30 HDMs have been identified. The majority of HDMs have JmjC-domain-containing proteins that confer substrate specificity and catalytic functions as demethylase, and only two LSD1 and LSD2 are original demethylases specific for lysine that lack the JmjC-domain [98]. Regulation of demethylases activity is possible via posttranscriptional as well as posttranslational mechanisms.…”

Section: Histone Demethylasesmentioning

confidence: 99%

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

et al. 2019

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Natural substances of plant origin exert health beneficiary efficacy due to the content of various phytochemicals. Significant anticancer abilities of natural compounds are mediated via various processes such as regulation of a cell’s epigenome. The potential antineoplastic activity of plant natural substances mediated by their action on posttranslational histone modifications (PHMs) is currently a highly evaluated area of cancer research. PHMs play an important role in maintaining chromatin structure and regulating gene expression. Aberrations in PHMs are directly linked to the process of carcinogenesis in cancer such as breast (BC), prostate (PC), and colorectal (CRC) cancer, common malignant diseases in terms of incidence and mortality among both men and women. This review summarizes the effects of plant phytochemicals (isolated or mixtures) on cancer-associated PHMs (mainly modulation of acetylation and methylation) resulting in alterations of chromatin structure that are related to the regulation of transcription activity of specific oncogenes, which are crucial in the development of BC, PC, and CRC. Significant effectiveness of natural compounds in the modulation of aberrant PHMs were confirmed by a number of in vitro or in vivo studies in preclinical cancer research. However, evidence concerning PHMs-modulating abilities of plant-based natural substances in clinical trials is insufficient.

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“…Xuan et al [67] showed indirect evidence of KDM6B involvement in periodontal inflammation through regulation of M2 macrophage polarization although the detailed mechanisms by which KDM6B regulates periodontal tissue responses to infection remains unknown. [68] …”

Section: Epigenetic Gene Regulation By Histone Demethylasesmentioning

confidence: 99%

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Juneius

2016

AJP

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Aim: To review the literature on the oral health status of the population, evidence-based understanding of epigenetic mechanisms, and its significant role in diseases occurring in the oral cavity. Background: Epigenetics is the study of heritable changes in gene expression that does not involve changes to the underlying DNA sequence. In other words, it is a change in phenotype without a change in genotype, which in turn affects the way cells read genes. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state. The field of epigenetics is quickly growing, and it is believed that both the environment and lifestyle can interact with the genome to influence epigenetic change. These changes may be reflected at various stages throughout a person's life and even in later generations. Conclusion: Epigenetic codes help us understand the biological phenotype that arises from the interaction of the human genome with the environment in health and in disease. Epigenetics is a major turn away from molecular biology. Current epigenetics not only offers new insights into gene regulation and heredity, but also it challenges the way we think about evolution, genetics, and development. Most interestingly, it suggests testable mechanisms whereby environmental factors (ranging from stress to infection) can influence genetic expression.

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Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation

Cited by 43 publications

References 120 publications

Genetic and Epigenetic Characterization of Pulpal and Periapical Inflammation

Genetic and Epigenetic Characterization of Pulpal and Periapical Inflammation

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

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