Epigenetic Effects of Gut Metabolites: Exploring the Path of Dietary Prevention of Type 1 Diabetes

Theyab, Ahmad Al; Almutairi, Turki; Al-Suwaidi, Abdulla M; Bendriss, Ghizlane; McVeigh, Clare; Châari, Ali

doi:10.3389/fnut.2020.563605

Cited by 18 publications

(21 citation statements)

References 175 publications

(223 reference statements)

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“…DNA analyses allowed for the identification of 88 methylation sites in B cells including those influencing genes related to the pathogenesis of diabetes such as HLA and subunit β of the interleukin receptor 2 (IL-2Rβ), and in terms of the entire genome of human pancreatic islets, 383 potential methylation locations have been identified [179]. Studies indicate that micro-RNA can participate in the autoimmune damage to β cells, regulation of the synthesis and release of insulin, and consequently, the pathogenesis of type 1 diabetes [181].…”

Section: Perspectives and Conclusion-can Nutrigenomics Be The Future?mentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

2021

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The physiological markers of autoimmune diabetes include functional disorders of the antioxidative system as well as progressing inflammation and the presence of autoantibodies. Even though people with type 1 diabetes show genetic predispositions facilitating the onset of the disease, it is believed that dietary factors can stimulate the initiation and progression of the disease. This paper analyses the possibility of using tea as an element of diet therapy in the treatment of type 1 diabetes. Based on information available in literature covering the last 10 years, the impact of regular tea consumption or diet supplements containing tea polyphenols on the oxidative status as well as inflammatory and autoimmune response of the organism was analyzed. Studies conducted on laboratory animals, human patients, and in vitro revealed positive effects of the consumption of tea or polyphenols isolated therefrom on the diabetic body. Few reports available in the literature pertain to the impact of tea on organisms affected by type 1 diabetes as most (over 85%) have focused on cases of type 2 diabetes. It has been concluded that by introducing tea into the diet, it is possible to alleviate some of the consequences of oxidative stress and inflammation, thus limiting their destructive impact on the patients’ organisms, consequently improving their quality of life, regardless of the type of diabetes. Furthermore, elimination of inflammation should reduce the incidence of immune response. One should consider more widespread promotion of tea consumption by individuals genetically predisposed to diabetes, especially considering the drink’s low price, easy availability, overall benefits to human health, and above all, the fact that it can be safely used over extended periods of time, regardless of the patient’s age.

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Section: Perspectives and Conclusion-can Nutrigenomics Be The Future?mentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

2021

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“…Recent research has addressed the role of the gut microbiome in autoimmune diseases [ 80 , 81 , 82 ]. Longitudinal studies on humans revealed that the diversity and intestinal dysbiosis of microbiota, which is regarded as a group of beneficial microorganisms, were decreased in patients with T1D.…”

Section: Overview Of the Modulatory Effects Of Host Microbiota On Autoimmune Diseasesmentioning

confidence: 99%

Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases

et al. 2021

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Autoimmunity is a complex and multifaceted process that contributes to widespread functional decline that affects multiple organs and tissues. The pandemic of autoimmune diseases, which are a global health concern, augments in both the prevalence and incidence of autoimmune diseases, including type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. The development of autoimmune diseases is phenotypically associated with gut microbiota-modulated features at the molecular and cellular levels. The etiology and pathogenesis of autoimmune diseases comprise the alterations of immune systems with the innate and adaptive immune cell infiltration into specific organs and the augmented production of proinflammatory cytokines stimulated by commensal microbiota. However, the relative importance and mechanistic interrelationships between the gut microbial community and the immune system during progression of autoimmune diseases are still not well understood. In this review, we describe studies on the profiling of gut microbial signatures for the modulation of immunological homeostasis in multiple inflammatory diseases, elucidate their critical roles in the etiology and pathogenesis of autoimmune diseases, and discuss the implications of these findings for these disorders. Targeting intestinal microbiome and its metabolomic associations with the phenotype of autoimmunity will enable the progress of developing new therapeutic strategies to counteract microorganism-related immune dysfunction in these autoimmune diseases.

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“…Nutrition is the main modulator of bacterial composition and abundance in the gastrointestinal tract, suggesting the opportunities for therapeutic nutritional approaches to manipulate microbiota composition and diversity [14,15]. Nutrigenomics and nutritional microbiomics approaches have received increasing attention and are currently being used to study respectively the mutual interactions between food and genes and between diet and microbiota in several diseases including cancer [16,17], cardiovascular [18,19], metabolic [20], and autoimmune diseases [21][22][23][24] in order to enable their better understanding, prevention and treatment through optimization of individuals' dietary intakes.…”

Section: Introductionmentioning

confidence: 99%

Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era

et al. 2021

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Modern high-throughput ‘omics’ science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ‘omics’ technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ‘omics technologies’ in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed.

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Epigenetic Effects of Gut Metabolites: Exploring the Path of Dietary Prevention of Type 1 Diabetes

Cited by 18 publications

References 175 publications

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases

Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era

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