2021
DOI: 10.21203/rs.3.rs-861068/v1
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Epigenetic Dysregulation of the Expression of PRSS3 Splice Variants Increases the Heterogeneity of Transcripts and Functionality in Human Hepatocellular Carcinoma

Abstract: Background Hepatocellular carcinoma (HCC) is one of the most lethal human tumors with extensive heterogeneity. Serine protease 3 (PRSS3) is an indispensable member of the trypsin family and has been implicated in the pathogenesis of several malignancies including HCC. However, paradoxical effects of PPRSS3 on carcinogenesis impede the utilization of its biomarker potential. We hereby systematically dissected the expression of four known splice variants of PRSS3 (PRSS3-SVs) and their functional relevance to HC… Show more

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