Epigenetic changes in status epilepticus

Henshall, David C.

doi:10.1111/epi.14502

Cited by 11 publications

(2 citation statements)

References 36 publications

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“…A growing body of evidence indicates that epilepsy and epilepsy by MiRNA epigenetic factors and gene product control, and epigenetic factors and gene product at the system level control to identify multiple genes and proteins in the epileptic brain samples increase of miRNAs epigenetic function directly, will help to better understand the complex mechanisms of epilepsy occurs [22].…”

Section: Mirna Epigenetic Mechanisms Implicated In Epilepsymentioning

confidence: 99%

Study on MiRNA Epigenetic Intervention for Epilepsy

Hu¹,

Mo²,

Cheng³

2022

JBM

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MiRNAs are a family of small non-coding RNAs that control levels of multiple proteins by post-transcriptionally decreasing messenger RNA stability and translation. MiRNA is a part of the epigenetic machinery. In addition to post-transcriptional gene silencing by miRNAs, the epigenetic mechanisms also include DNA methylation, histone modifications and their crosstalk. Epigenetic modifications were reported to play an important role in many disease onsets and progressions and can be used to explain several features of epilepsy. However, miRNA not only function as a part of epigenetic machinery, but are also epigenetically modified by DNA methylation and histone modification like any other protein-coding gene. There is a strong connection between epigenetic and MiRNA, and any dysregulation of this complex system can result in various physiological and pathological conditions. Currently, there is an unmet need for antiepileptic drugs that truly prevent the development of epilepsy in high-risk populations. New findings in animal models and human brain tissue suggest that microRNAs play a crucial role in epileptogenesis and the pathophysiology of chronic epilepsy. Objectives: This paper focuses on the epigenetic role of miRNA in the development of epilepsy and potential targets for drug therapy. Methods: In this paper, through the keywords epilepsy, epigenetic, methylation, miRNA, non-coding RNA search in PubMed, SPIS, GeenMedical, Google Scholar and Web of Science, to study the potential application of miRNA epigenetic regulation in the treatment of epilepsy. Results: Future treatments that manipulate miRNA epigenetic processes, such as Anti-oligonucleotides, DNA methylation and Nucleic Acid Aptamers, to treat or prevent epilepsy. Conclusion: Overall, miRNA epigenetic drugs have become a new frontier target to achieve a cure for epilepsy.

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Section: Mirna Epigenetic Mechanisms Implicated In Epilepsymentioning

confidence: 99%

Study on MiRNA Epigenetic Intervention for Epilepsy

Hu¹,

Mo²,

Cheng³

2022

JBM

View full text Add to dashboard Cite

show abstract

“…Therefore, it is necessary to develop new methods for treating epilepsy by targeting its pathogenesis. Based on previous reports, epigenetic therapy can potentially prevent seizures and cure epilepsy [4].…”

Section: Introductionmentioning

confidence: 99%

CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy

Zhao

Wang

et al. 2022

Neuropathology Appl Neurobio

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Objectives Several reports suggest that epigenetic therapy may be a potential method for treating epilepsy, and circular RNAs (circRNAs) play important roles in mediating the epigenetic mechanisms associated with epilepsy; however, currently there are no effective treatment methods to prevent the progression of epileptogenesis. The circRNA serine/arginine repetitive matrix 4 (circSRRM4) was found to exert regulatory effects in temporal lobe epilepsy (TLE); however, the mechanisms involved are still unknown. Materials and methods To elucidate the molecular mechanism of circSRRM4, we investigated human epileptic brain tissue, epileptic rats, neuron and astrocyte cell lines using RT‐qPCR, western blot, fluorescence in situ hybridisation, immunofluorescence staining, Nissl stain, micro‐PET‐CT, RNA‐pulldown, liquid chromatography–mass spectrometry, and RBP immunoprecipitation techniques. Furthermore, we evaluated the pyruvate kinase M1/2 (PKM) expression patterns in the human and rat models of TLE. Results We detected the increased circSRRM4 expression in the hypometabolic lesions of patients with TLE and discovered that circSrrm4 has specific spatiotemporal characteristics in rats with kainic acid‐induced epilepsy. The decreased PKM1 expression and increased PKM2 expression were similar to the Warburg effect in tumours. Notably, circSrrm4 silencing reduced the incidence and frequency of epilepsy, improved local hypometabolism, and prevented neuronal loss and astrocyte activation. Conclusion PKM2 promotes lactic acid production in the astrocytes by inducing glycolysis, thereby contributing to the energy source for epileptic seizures. Notably, circSRRM4 combines with and inhibits serine and arginine rich splicing factor 3 (SRSF3) from joining the ubiquitin–proteasome pathway, improving the SRSF3‐regulated alternative splicing of PKM, and consequently stimulating glycolysis in cells.

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A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

et al. 2022

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The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research‐related methods. Here, we have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for genomics, transcriptomics, and epigenomics in rodent models of epilepsy, with a specific focus on adult rats and mice. We discuss the important elements that need to be considered for genomics, transcriptomics, and epigenomics methodologies, providing a rationale for the parameters that should be collected. This is the first in a two‐part series of omics papers with the second installment to cover proteomics, lipidomics, and metabolomics in adult rodents.

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Epigenetic changes in status epilepticus

Cited by 11 publications

References 36 publications

Study on MiRNA Epigenetic Intervention for Epilepsy

Study on MiRNA Epigenetic Intervention for Epilepsy

CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

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