Epigenetic Biomarkers for Risk Assessment of Particulate Matter Associated Lung Cancer

Bhargava, Arpit; Bunkar, Neha; Aglawe, Aniket; Pandey, Kailash C.; Tiwari, Rajnarayan R; Chaudhury, Koel; Goryacheva, Irina Yu.; Mishra, Pradyumna Kumar

doi:10.2174/1389450118666170911114342

Cited by 35 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Truncation of the SET domain has been shown to disrupt gene regulation and result in widespread histone methylation disturbances . Histone methylation is one type of epigenetic modifications known to reflect the vital cellular changes in the individuals with lung cancer . It is well known that the epigenome serves as an interface between the environment and the genome …”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of age‐related somatic mutation profiles in Chinese young lung adenocarcinoma patients

Yang

et al. 2019

Cancer Medicine

View full text Add to dashboard Cite

Background Lung adenocarcinoma in young adults is a rare entity with the oncogenic genetic alterations associated being poorly understood. In the present study, the effect of genetic alterations in lung adenocarcinoma patients diagnosed in young patients is reported. Methods Twenty young lung adenocarcinoma patients (age years: median: 33.5, range: 24‐36) were enrolled in the current study and 24 patients who were at common age of the disease onset (age years: median: 61.5, range: 52‐79) were selected for comparison. Paraffin sections of lung adenocarcinoma were analyzed using the whole‐exome sequencing platform. Results Similar number of somatic mutations per tumor were found in the young patients and their older counterparts. Although no age‐related differences were detected in the numbers of lung adenocarcinoma patients harboring well‐known gene variants, mutations in FRG1 and KMT2C were associated with a younger age especially after correcting for tobacco smoking and sex (FRG1: P = 0.027, KMT2C: P = 0.046). Five genetic variants showed higher alteration frequencies in young patients compared to the unclassified East Asian population, suggesting these mutations as disease‐related hereditary germline variants. Conclusions These results suggest different characteristics of lung adenocarcinoma between the young and the patients at common age of onset. Young patients with lung adenocarcinoma have a distinctly unique prevalence of oncogenic genetic alterations.

show abstract

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of age‐related somatic mutation profiles in Chinese young lung adenocarcinoma patients

Yang

et al. 2019

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…Analysis of circulating microRNAs (cmiRNAs) before surgical operation (BSO) and after the surgical operation (ASO) has provided significant information for NSCLC diagnosis, progression, and outcomes of treatment [2]. One of the epigenetic biomarkers, known as cmiRNA, serves as a potential source for diagnosing NSCLC and its subtypes [3][4][5][6]. There are three important advantages in using cmiRNAs as a biomarker for NSCLC; they are as follows: (1) diagnostic feasibility from body fluids, (2) elevated stability and protection from endogenous enzymes (RNAase), and (3) accumulation of pathologic information from various tumorous sites, which overcomes the difficulty of tumor heterogenicity [7].…”

Section: Introductionmentioning

confidence: 99%

Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis

Huang

Wei

Kaliamurthi

et al. 2020

JPM

View full text Add to dashboard Cite

Analysis of circulating miRNAs (cmiRNAs) before surgical operation (BSO) and after the surgical operation (ASO) has been informative for lung adenocarcinoma (LUAD) diagnosis, progression, and outcomes of treatment. Thus, we performed a biological network analysis to identify the potential target genes (PTGs) of the overexpressed cmiRNA signatures from LUAD samples that had undergone surgical therapy. Differential expression (DE) analysis of microarray datasets, including cmiRNAs (GSE137140) and cmRNAs (GSE69732), was conducted using the Limma package. cmiR-1246 was predicted as a significantly upregulated cmiRNA of LUAD samples BSO and ASO. Then, 9802 miR-1246 target genes (TGs) were predicted using 12 TG prediction platforms (MiRWalk, miRDB, and TargetScan). Briefly, 425 highly expressed overlapping miRNA-1246 TGs were observed between the prediction platform and the cmiRNA dataset. ClueGO predicted cell projection morphogenesis, chemosensory behavior, and glycosaminoglycan binding, and the PI3K–Akt signaling pathways were enriched metabolic interactions regulating miRNA-1245 overlapping TGs in LUAD. Using 425 overlapping miR-1246 TGs, a protein–protein interaction network was constructed. Then, 12 PTGs of three different Walktrap modules were identified; among them, ubiquitin-conjugating enzyme E2C (UBE2C), troponin T1(TNNT1), T-cell receptor alpha locus interacting protein (TRAIP), and ubiquitin c-terminal hydrolase L1(UCHL1) were positively correlated with miR-1246, and the high expression of these genes was associated with better overall survival of LUAD. We conclude that PTGs of cmiRNA-1246 and key pathways, namely, ubiquitin-mediated proteolysis, glycosaminoglycan binding, the DNA metabolic process, and the PI3K–Akt–mTOR signaling pathway, the neurotrophin and cardiomyopathy signaling pathway, and the MAPK signaling pathway provide new insights on a noninvasive prognostic biomarker for LUAD.

show abstract

“…Desafortunadamente, en países como Colombia los trámites administrativos pueden hacer del proceso diagnóstico un camino largo y tortuoso, por lo que se vuelve indispensable crear estrategias locales rentables, eficaces, eficientes, multidisciplinarias, al alcance de los pacientes y con evidencia suficiente para adelantar y priorizar los estudios de detección temprana, caracterización y estratificación de cáncer de pulmón tales como marcadores de inmunohistoquímica y pruebas moleculares específicos basados en los hallazgos fibrobroncoscópicos e histológicos. [28][29][30][31] Esto permitiría realizar un diagnóstico oportuno y por consiguiente dar un tratamiento dirigido en un menor tiempo.…”

Section: Resultsunclassified

Concordancia diagnóstica entre la broncoscopia y la histopatología en pacientes con neoplasias pulmonares

Araque

Chaves

et al. 2019

NCT Neumología Y Cirugía De Tórax

View full text Add to dashboard Cite

Este artículo puede ser consultado en versión completa en: www.medigraphic.com/neumologia RESUMEN. Antecedentes: El cáncer de pulmón es una de las principales causas de muerte a nivel mundial, cuando se descubre generalmente se hace en estadíos avanzados, constituyendo un mal pronóstico. Este último mejora con un diagnóstico temprano y manejo oportuno. El objetivo de este estudio es evaluar la concordancia entre los hallazgos fibrobroncoscópicos e histopatológicos en pacientes con neoplasias pulmonares, y de esta manera conocer si existe la viabilidad de realizar estudios complementarios de inmunohistoquímica o pruebas moleculares a los casos sospechosos de malignidad en la fibrobroncoscopia. Materiales y métodos: Se realizó un estudio de concordancia diagnóstica incluyendo pacientes mayores de 18 años con diagnóstico de neoplasias pulmonares. Se estimó el acuerdo absoluto y el acuerdo más allá del azar mediante el estadístico de concordancia de Kappa de Cohen. Resultados: Se incluyeron en el estudio 369 casos, de los cuales 207 pacientes (56.1%) fueron de sexo masculino. La mediana de la edad fue de 58 años (RIQ 23). La concordancia del diagnóstico fibrobroncoscópico e histopatológico de neoplasia pulmonar fue moderada con un índice de Kappa positivo de 0.605 (IC95% de 0.496-0.715). La tasa de acuerdo fue del 89%. El adenocarcinoma fue el tumor que mostró menor acuerdo entre las dos pruebas. Conclusiones: El presente estudio mostró una concordancia moderada entre los hallazgos fibrobroncoscópicos e histopatológicos. Estos hallazgos confirman que la sospecha en la endoscopia es fundamental para encaminar el diagnóstico y solicitar pruebas preliminares para un adecuado y oportuno estudio histológico.Palabras clave: Neoplasia pulmonar, cáncer, fibrobroncoscopia, biopsia, concordancia diagnóstica. Diagnostic concordance between bronchoscopy and histopathology in patients with pulmonary neoplasmsAbStRACt. background: Lung cancer is one of the leading causes of death worldwide, it is generally discovered in advanced stages, constituting a poor prognosis, which this last one has an improvement with early diagnosis and timely management. The aim of this study is evaluate the concordance between the fibrobronchoscopic and histopathological findings in patients with pulmonary neoplasias, in order to perform complementary studies of immunohistochemistry or molecular tests to suspected cases of malignancy in the fibrobronchoscopic. Materials and methods: A diagnostic agreement study was carried out, including patients older than 18 years with a diagnosis of pulmonary neoplasms. Absolute agreement and agreement beyond chance were estimated using Cohen's Kappa concordance statistic. Results: 369 cases were included in the study, of which 207 patients (56.1%) were male. The median of age was 58 years (IQR 23). The concordance of the fibrobronchoscopic and histopathological diagnosis of pulmonary neoplasia was moderate with a positive Kappa index of 0.605 (95% CI of 0.496-0.715). The agreement rate was 89%. The adenocarcinoma w...

show abstract

Epigenetic Biomarkers for Risk Assessment of Particulate Matter Associated Lung Cancer

Cited by 35 publications

References 0 publications

Comprehensive analysis of age‐related somatic mutation profiles in Chinese young lung adenocarcinoma patients

Comprehensive analysis of age‐related somatic mutation profiles in Chinese young lung adenocarcinoma patients

Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis

Concordancia diagnóstica entre la broncoscopia y la histopatología en pacientes con neoplasias pulmonares

Contact Info

Product

Resources

About