Epigenetic and non-epigenetic regulation of syncytin-1 expression in human placenta and cancer tissues

Huang, Qiang; Chen, Haibin; Li, Jinping; Oliver, M.; Ma, Xiaoling; Byck, David; Gao, Ya; Jiang, Shi‐Wen

doi:10.1016/j.cellsig.2013.11.002

Cited by 43 publications

(35 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Syncytin-1 gene is located on chromosome 7, and is subject to dynamic genetic and epigenetic regulations [62]. As previously discussed, the syncytium is formed by the fusion of cytotrophoblasts; syncytin-1 is the key mediator of the fusion process.…”

Section: Syncytin-1 As a Key Regulator Of Syncytium Turnovermentioning

confidence: 99%

“…However, it is not clear at this time through what molecular mechanism the hypoxic condition may lead to the inhibition of syncytin-1 expression. Aberrant expression of DNA methyltransferase (DNMT), the enzyme carrying out DNA methylation of genomic DNA, was thought to play a role in gene inhibition [22, 62]. …”

Section: Syncytin-1 As a Key Regulator Of Syncytium Turnovermentioning

confidence: 99%

“…They found that syncytin-1 downregulated the concentrations of important cytokines, including TNF-α, CXCL10, and IFN γ in the maternal circulation by some yet to be identified mechanisms [68]. Deficiency of syncytin-1 expression, therefore, may induce a pro-inflammatory state due to the increased release of these cytokines, which may be responsible for the elevated systemic inflammation seen in preeclampsia [62]. These findings raised the possibility that syncytin-1 may not only participate in the regulation of placental structure and function, but also may impose systemic impact on the maternal adaptation and fetal development in human pregnancy.…”

Section: Syncytin-1 As a Key Regulator Of Syncytium Turnovermentioning

confidence: 99%

See 2 more Smart Citations

Morphological changes of placental syncytium and their implications for the pathogenesis of preeclampsia

Roland

Ren

et al. 2015

Cell. Mol. Life Sci.

Self Cite

101

View full text Add to dashboard Cite

Preeclampsia is a hypertensive disease that complicates many pregnancies, typically presenting with new-onset or worsening hypertension and proteinuria. It is well recognized that the placental syncytium plays a key role in the pathogenesis of preeclampsia. This review summarizes the findings pertaining to the structural alterations in the syncytium of preeclamptic placentas and analyzes their pathological implications for the development of preeclampsia. Changes in the trophoblastic lineage, including those in the proliferation of cytotrophoblasts, the formation of syncytiotrophoblast through cell fusion, cell apoptosis and syncytial deportation, are discussed in the context of preeclampsia. Extensive correlations are made between functional deficiencies and the alterations on the levels of gross anatomy, tissue histology, cellular events, ultrastructure, molecular pathways, and gene expression. Attention is given to the significance of dynamic changes in the syncytial turnover in preeclamptic placentas. Specifically, experimental evidences for the complex and obligatory role of syncytin-1 in cell fusion, cell-cycle regulation at the G1/S transition, and apoptosis through AIF-mediated pathway, are discussed in detail in the context of syncytium homeostasis. Finally, the recent observations on the aberrant fibrin deposition in the trophoblastic layer and the trophoblast immature phenotype in preeclamptic placentas and their potential pathogenic impact are also reviewed.

show abstract

Section: Syncytin-1 As a Key Regulator Of Syncytium Turnovermentioning

confidence: 99%

Section: Syncytin-1 As a Key Regulator Of Syncytium Turnovermentioning

confidence: 99%

Section: Syncytin-1 As a Key Regulator Of Syncytium Turnovermentioning

confidence: 99%

See 1 more Smart Citation

Morphological changes of placental syncytium and their implications for the pathogenesis of preeclampsia

Roland

Ren

et al. 2015

Cell. Mol. Life Sci.

Self Cite

101

View full text Add to dashboard Cite

show abstract

“…The human syncytin genes have trophoblast-specific enhancers that contain binding sites for transcription factors such as glial cell missing 1 (GCM1), that induce the expression of the syncytins [45]. GCM1 is a transcription factor that is specifically expressed in trophoblast cells and has been shown to increase syncytin-1 when overexpressed in trophoblast cell lines [46,47].…”

Section: Comparative Placental Transcriptomicsmentioning

confidence: 99%

A review of inter- and intraspecific variation in the eutherian placenta

Gundling

Wildman

2015

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

The placenta is one of the most morphologically variable mammalian organs. Four major characteristics are typically discussed when comparing the placentas of different eutherian species: placental shape, maternal-fetal interdigitation, intimacy of the maternal-fetal interface and the pattern of maternal-fetal blood flow. Here, we describe the evolution of three of these features as well as other key aspects of eutherian placentation. In addition to interspecific anatomical variation, there is also variation in placental anatomy and function within a single species. Much of this intraspecific variation occurs in response to different environmental conditions such as altitude and poor maternal nutrition. Examinations of variation in the placenta from both intra-and interspecies perspectives elucidate different aspects of placental function and dysfunction at the maternal-fetal interface. Comparisons within species identify candidate mechanisms that are activated in response to environmental stressors ultimately contributing to the aetiology of obstetric syndromes such as pre-eclampsia. Comparisons above the species level identify the evolutionary lineages on which the potential for the development of obstetric syndromes emerged.

show abstract

“…ERVW-1 gene expression is regulated on the transcriptional, post-transcriptional, translational and epigenetic levels (20). Studies have shown that dysregulation of syncytin 1 expression in trophoblast correlates with the development and severity of preeclampsia (4,19,21) and that the regulation of syncytin 1 can be affected already at the transcriptional level (22).…”

Section: Introductionmentioning

confidence: 99%

ERVW-1 gene polymorphisms related to preeclampsia

Priščáková¹,

J²,

Petrovič³

et al. 2016

BLL

View full text Add to dashboard Cite

OBJECTIVES: Identifi cation of genetic association between the gene ERVW-1 and preeclampsia. BACKGROUND: Preeclampsia is a multifactorial disease affecting women during pregnancy and it is one of the main causes of perinatal and maternal morbidity and mortality. The pathophysiology of preeclampsia is very complex and several aspects of the disease have not been elucidated yet. Abnormal placentation frequently occurs during severe preeclampsia. Protein syncytin 1, a product of the ERVW-1 gene, plays a crucial role in the syncytiotrophoblast differentiation and optimal placentation. The syncytin 1 expression is disturbed during preeclampsia. The main focus of this study was the analysis of the ERVW-1 regulatory regions and identifi cation of DNA polymorphisms associated with preeclamptic cases in Slovak population. METHODS: Regulatory region of gene ERVW-1 was analyzed by sequencing to identify genetic variants. RESULTS: We identifi ed four DNA variants, namely rs4727276, rs148592540, rs569899772 and rs555416193, in samples of Slovak population. CONCLUSION: No relation between polymorphisms and preeclampsia was observed, indicating that further investigations with a larger sampling are still required. However, our work represents new original approach in genetic differential diagnosis of preeclampsia with possible useful fi ndings in the future (Tab. 3, Fig. 1

show abstract

Epigenetic and non-epigenetic regulation of syncytin-1 expression in human placenta and cancer tissues

Cited by 43 publications

References 76 publications

Morphological changes of placental syncytium and their implications for the pathogenesis of preeclampsia

Morphological changes of placental syncytium and their implications for the pathogenesis of preeclampsia

A review of inter- and intraspecific variation in the eutherian placenta

ERVW-1 gene polymorphisms related to preeclampsia

Contact Info

Product

Resources

About