Epigenetic alterations and decreasing insecticide sensitivity of the Asian tiger mosquito Aedes albopictus

Oppold, Ann-Marie; Kreß, Aljoscha; Bussche, Julie Vanden; Diogo, João Barateiro; Kuch, Ulrich; Oehlmann, Jörg; Vandegehuchte, M.; Müller, Ruth

doi:10.1016/j.ecoenv.2015.06.036

Cited by 55 publications

(42 citation statements)

References 62 publications

(96 reference statements)

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“…Evidence suggests that insecticide sensitivity in insects might be regulated by epigenetic mechanisms involving DNA methylation (Oppold et al, 2015) and chromatin modifications (Hu et al, 2017;Scientific Reports 7:41255 Involves any process to change state and activity of molecular processes. The herewith associated gene "transient receptor potential channel pyrexia" is responsive to high temperatures and involved in protection and tolerance from high temperature stress in D. melanogaster (Lee et al, 2005).…”

Section: Methylationmentioning

confidence: 99%

The genomic footprint of climate adaptation in Chironomus riparius

et al. 2018

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The gradual heterogeneity of climatic factors poses varying selection pressures across geographic distances that leave signatures of clinal variation in the genome. Separating signatures of clinal adaptation from signatures of other evolutionary forces, such as demographic processes, genetic drift and adaptation, to nonclinal conditions of the immediate local environment is a major challenge. Here, we examine climate adaptation in five natural populations of the harlequin fly Chironomus riparius sampled along a climatic gradient across Europe. Our study integrates experimental data, individual genome resequencing, Pool-Seq data and population genetic modelling. Common-garden experiments revealed significantly different population growth rates at test temperatures corresponding to the population origin along the climate gradient, suggesting thermal adaptation on the phenotypic level. Based on a population genomic analysis, we derived empirical estimates of historical demography and migration. We used an F outlier approach to infer positive selection across the climate gradient, in combination with an environmental association analysis. In total, we identified 162 candidate genes as genomic basis of climate adaptation. Enriched functions among these candidate genes involved the apoptotic process and molecular response to heat, as well as functions identified in studies of climate adaptation in other insects. Our results show that local climate conditions impose strong selection pressures and lead to genomic adaptation despite strong gene flow. Moreover, these results imply that selection to different climatic conditions seems to converge on a functional level, at least between different insect species.

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Section: Methylationmentioning

confidence: 99%

The genomic footprint of climate adaptation in Chironomus riparius

et al. 2018

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“…Evidence suggests that insecticide sensitivity in insects might be regulated by epigenetic mechanisms involving DNA methylation (Oppold et al 2015) and chromatin modifications ( Hu et al 2017, Scientific Reports 7:41255). Genetic adaptations interacting with the epigenetic machinery might be a response to insecticide stress on a local scale.…”

Section: Functional Basis Of Local and Clinal Adaptation In C Ripariusmentioning

confidence: 99%

The genomic footprint of climate adaptation inChironomus riparius

Oppold

Wieser

Schell

et al. 2017

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The gradual heterogeneity of climatic factors pose varying selection pressures across geographic distances that leave signatures of clinal variation in the genome. Separating signatures of clinal adaptation from signatures of other evolutionary forces, such as demographic processes, genetic drift, and adaptation to non-clinal conditions of the immediate local environment is a major challenge. Here, we examine climate adaptation in five natural populations of the harlequin fly Chironomus riparius sampled along a climatic gradient across Europe. Our study integrates experimental data, individual genome resequencing, Pool-Seq data, and population genetic modelling. Common-garden experiments revealed a positive correlation of population growth rates corresponding to the population origin along the climate gradient, suggesting thermal adaptation on the phenotypic level. Based on a population genomic analysis, we derived empirical estimates of historical demography and migration. We used an F ST outlier approach to infer positive selection across the climate gradient, in combination with an environmental association analysis. In total we identified 162 candidate genes as genomic basis of climate adaptation. Enriched functions among these candidate genes involved the apoptotic process and molecular response to heat, as well as functions identified in other studies of climate adaptation in other insects. Our results show that local climate conditions impose strong selection pressures and lead to genomic adaptation despite strong gene flow. Moreover, these results imply that selection to different climatic conditions seems to converge on a functional level, at least between different insect species.

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Section: Epigenetic Mechanisms a Component Of The Rapid Response To mentioning

confidence: 99%

“…Lastly, Oppold et al () and Kreß, Oppold, Kuch, Oehlmann, and Müller () studied epigenetic modifications in the Asian tiger mosquito ( A. albopictus ), which has spread from South‐East Asia to every continent except Antarctica and Australia. Invasive populations of this vector for many diseases have low genetic diversity (Kreß et al, ; Oppold et al, ), yet exhibit rapid adaptive responses to different environments, such as chemical compounds or resistance to cold, and showed alteration of DNA methylation levels. These results should be taken with caution since the levels of DNA methylation in insects are in general very low and some recent papers suggest an absence of significant DNA methylation in Diptera (Bewick, Vogel, Moore, & Schmitz, ; Provataris, Meusemann, Niehuis, Grath, & Misof, ).…”

Section: Epigenetic Mechanisms a Component Of The Rapid Response To mentioning

confidence: 99%

Biological invasion: The influence of the hidden side of the (epi)genome

et al. 2019

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Understanding the mechanisms underlying biological invasions and rapid adaptation to global change remains a fundamental challenge, particularly in small populations lacking in genetic variation. Two understudied mechanisms that could facilitate adaptive evolution and adaptive plasticity are the increased genetic variation due to transposable elements (TEs), and associated or independent modification of gene expression through epigenetic changes. Here, we focus on the potential role of these genetic and non‐genetic mechanisms for facilitating invasion success. Because novel or stressful environments are known to induce both epigenetic changes and TE activity, these mechanisms may play an underappreciated role in generating phenotypic and genetic variation for selection to act on. We review how these mechanisms operate, the evidence for how they respond to novel or stressful environments, and how these mechanisms can contribute to the success of biological invasions by facilitating adaptive evolution and phenotypic plasticity. Because genetic and phenotypic variations due to TEs and epigenetic changes are often well regulated or “hidden” in the native environment, the independent and combined contribution of these mechanisms may only become important when populations colonize novel environments. A focus on the mechanisms that generate and control the expression of this variation in new environments may provide insights into biological invasions that would otherwise not be obvious. Global changes and human activities impact on ecosystems and allow new opportunities for biological invasions. Invasive species succeed by adapting rapidly to new environments. The degree to which rapid responses to environmental change could be mediated by the epigenome—the regulatory system that integrates how environmental and genomic variation jointly shape phenotypic variation—requires greater attention if we want to understand the mechanisms by which populations successfully colonize and adapt to new environments. A free Plain Language Summary can be found within the Supporting Information of this article.

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Epigenetic alterations and decreasing insecticide sensitivity of the Asian tiger mosquito Aedes albopictus

Cited by 55 publications

References 62 publications

The genomic footprint of climate adaptation in Chironomus riparius

The genomic footprint of climate adaptation in Chironomus riparius

The genomic footprint of climate adaptation inChironomus riparius

Biological invasion: The influence of the hidden side of the (epi)genome

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