“…[34][35][36] Moreover, the reversible nature and faster dynamics of epigenetic changes are of major interest in the targeting of intervention, providing key motivation for pharmaceutical development over the last decade. 37,38 The need, therefore, to understand epigenetic changes and their influence on disease has stimulated development of numerous computational approaches and tools, for application to data generation, mapping and management, as well as analysis and therapy. While the Human Genome Project (1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003) focused on sequencing all genes in human DNA (~20,000, with some three billion base-pairs), a similar largescale project, the Epigenomics Road Map (2008-date), is exploring specific patterns of epigenetic modifications, with the principal aim of creation of a map of the epigenome for multiple tissue types and cancers.…”