Epigallocatechin gallate induces a hepatospecific decrease in the CYP3A expression level by altering intestinal flora

Ikarashi, Nobutomo; Ogawa, Sosuke; Hirobe, Ryuta; Kon, Risako; Kusunoki, Yoshiki; Yamashita, Marin; Mizukami, Nanaho; Kaneko, Miho; Wakui, Nobuyuki; Machida, Yoshiaki; Sugiyama, Kiyoshi

doi:10.1016/j.ejps.2017.01.022

Cited by 22 publications

(14 citation statements)

References 41 publications

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“…Thus, although we have not conducted a pharmacokinetic study of AP, it is considered that components containing AP are unlikely to affect the skin after being absorbed into the body. Meanwhile, we have confirmed that polyphenols change the flora in the large intestine, resulting in substantial alteration of hepatic functional molecules [7,8]. Therefore, we considered that there is a possibility that AP changes the gut microbiota and inhibits symptoms of atopic dermatitis.…”

Section: Discussionmentioning

confidence: 84%

“…Thus, drugs or foods that correct the gut microbiota may be useful for atopic dermatitis. To date, we have clarified that polyphenols, which have a poor absorption rate in the digestive tract, change the flora in the large intestine, resulting in substantial alteration of hepatic functional molecules [7,8]. Thus, it was considered that polyphenols may improve atopic dermatitis through the change of gut microbiota, as well as probiotics.…”

Section: Introductionmentioning

confidence: 99%

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Acacia Polyphenol Ameliorates Atopic Dermatitis in Trimellitic Anhydride-Induced Model Mice via Changes in the Gut Microbiota

Ikarashi

Fujitate

Togashi

et al. 2020

Foods

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We have previously shown that acacia polyphenol (AP), which was extracted from the bark of Acacia mearnsii De Wild, exerts antiobesity, antidiabetic, and antihypertensive effects. In this study, we examined the effect of AP on atopic dermatitis. Trimellitic anhydride (TMA) was applied to the ears of mice to create model mice with atopic dermatitis. The frequency of scratching behavior in the TMA-treated group was significantly higher than that in the control group, and the expression levels of inflammatory markers (tumor necrosis factor-α, interleukin-6, inducible nitric oxide synthase, and cyclooxygenase-2) in the skin also increased. In contrast, both the frequency of scratching behavior and the expression levels of skin inflammatory markers in the AP-treated group were significantly lower than those in the TMA-treated group. The abundances of beneficial bacteria, such as Bifidobacterium spp. and Lactobacillus spp., increased in the AP-treated group compared with the TMA-treated group. Furthermore, the abundances of Bacteroides fragilis and Clostridium coccoides in the gut, which are known for anti-inflammatory properties, increased significantly with AP administration. The present results revealed that AP inhibits TMA-induced atopic dermatitis-like symptoms. In addition, the results also suggested that this effect may be associated with the mechanism of gut microbiota improvement.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Acacia Polyphenol Ameliorates Atopic Dermatitis in Trimellitic Anhydride-Induced Model Mice via Changes in the Gut Microbiota

Ikarashi

Fujitate

Togashi

et al. 2020

Foods

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“…It is especially important to note that the relative proportion of Bacteroidetes to Firmicutes and bacterial alpha diversity are markedly decreased in both obese humans and obese mice [25,63,64,65]. Further studies have confirmed EGCG-induced changes to gut ecology [66]. Additionally, administration of green tea polyphenols appears to modulate gut microbiota diversity, including restoration of the Bacteroidetes to Firmicutes ratio resulting in body weight loss in mice fed a high fat diet [65].…”

Section: Discussionmentioning

confidence: 99%

Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice

et al. 2019

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The main purpose of this study was to investigate the hepatotoxic potential and effects on the gut microbiome of decaffeinated green tea extract (dGTE) in lean B6C3F1 mice. Gavaging dGTE over a range of 1X–10X mouse equivalent doses (MED) for up to two weeks did not elicit significant histomorphological, physiological, biochemical or molecular alterations in mouse livers. At the same time, administration of dGTE at MED comparable to those consumed by humans resulted in significant modulation of gut microflora, with increases in Akkermansia sp. being most pronounced. Results of this study demonstrate that administration of relevant-to-human-consumption MED of dGTE to non-fasting mice does not lead to hepatotoxicity. Furthermore, dGTE administered to lean mice, caused changes in gut microflora comparable to those observed in obese mice. This study provides further insight into the previously reported weight management properties of dGTE; however, future studies are needed to fully evaluate and understand this effect.

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“…Ikarashi et al [ 21 ] revealed that the intake of a high-dose of green tea polyphenols results in a liver-specific decrease in the drug-metabolizing enzyme cytochrome P450 3A (CYP3A) expression level during an in vivo test. Ikarashi et al [ 22 ] evaluated the liver-specific decrease in the CYP3A expression level observed after a high-dose intake of EGCG. Owing to the fact that EGCG, which is not absorbed in the intestine, causes a decrease in the level of lithocholic acid (LCA)-producing bacteria of Clostridium cluster XIVa in the colon, the level of LCA in the liver decreases, resulting in a decrease in the nuclear translocation of pregnane X receptor (PXR), which in turn leads to the observed decrease in the expression level of CYP3A.…”

Section: Discussionmentioning

confidence: 99%

Utilization of Flavonoid Compounds from Bark and Wood. III. Application in Health Foods

Ogawa¹,

Matsuo

Tanaka

et al. 2018

Molecules

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Dietary supplements ACAPOLIA® and ACAPOLIA PLUS have been sold in Japan under the classification “Foods in General” for a number of years. In April 2015, the classification of “Foods with Function Claims” was introduced in Japan to make more products available to the public that were clearly labeled with functional claims based on scientific evidence. In order to obtain recognition of ACAPOLIA PLUS under this new classification, the following information needed to be established. The safety of the bark extract of Acacia mearnsii was shown from the history of the long-term safe consumption of the extract as a health supplement, together with several additional clinical safety tests. Robinetinidol-(4α,8)-catechin was detected by high performance liquid chromatography (HPLC) in the supplement and was suitable for use as the basis of the quantitative analysis. In clinical tests, the amount of change in the plasma glucose concentration in the initial 60 min after rice consumption by a test group who had been given the Acadia extract was significantly lower than the glucose concentration in the group that was given a placebo. The blood glucose incremental areas under the curve (IAUC) in the first 60 min after rice consumption were also significantly lower in the Acacia group. The functional mechanisms were explained in terms of the inhibition of the absorption of glucose in the small intestine and the reduction in the activity of the digestive enzymes caused by proanthocyanidins derived from A. mearnsii bark. As a result, ACAPOLIA PLUS was accepted as a “Food with Function Claims” in August 2016. ACAPOLIA PLUS is now sold under this new classification. The growth of a typical intestinal bacterium is inhibited by an extract containing flavonoid compounds from A. mearnsii bark; thus, one of the future directions of study must be a comprehensive investigation of the effect that flavonoid compounds, proanthocyanidins, have on intestinal bacteria.

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Epigallocatechin gallate induces a hepatospecific decrease in the CYP3A expression level by altering intestinal flora

Cited by 22 publications

References 41 publications

Acacia Polyphenol Ameliorates Atopic Dermatitis in Trimellitic Anhydride-Induced Model Mice via Changes in the Gut Microbiota

Acacia Polyphenol Ameliorates Atopic Dermatitis in Trimellitic Anhydride-Induced Model Mice via Changes in the Gut Microbiota

Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice

Utilization of Flavonoid Compounds from Bark and Wood. III. Application in Health Foods

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