Epigallocatechin Gallate-Induced Histamine Release in Patients with Green Tea-Induced Asthma

Shirai, Toshihiro; Sato, Atsuhiko; Chida, Kingo; Hayakawa, Hiroshi; Akiyama, Jinichiro; Iwata, Masatoshi; Taniguchi, Masami; Reshad, Khaled; Hara, Yukihiko

doi:10.1016/s1081-1206(10)63087-6

Cited by 28 publications

(16 citation statements)

References 13 publications

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“…In fact, agents responsible for OA among herbal and fruit tea processors have still not been identified. Shirai et al (43) suggested that epigallocatechin gallate (EGCG) could be the causative agent of green tea-induced asthma. As the examined plant did not process green tea, we did not include EGCG in the tested workplace allergens.…”

Section: Discussionmentioning

confidence: 99%

Occupational Asthma in Subjects Occupationally Exposed to Herbal and Fruit Tea Dust

Минов¹,

Karadžinska-Bislimovska²,

Vasilevska

et al. 2007

Archives of Industrial Hygiene and Toxicology

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We performed a cross-sectional study to detect occupational asthma (OA) in 63 subjects occupationally exposed to herbal and fruit tea dust and in 63 corresponding controls. The evaluation included a questionnaire, skin prick tests to workplace and common inhalant allergens, spirometry, and histamine challenge test. The evaluation of the work-relatedness of asthma in the exposed workers was based on serial peak expiratory flow rate (PEFR) measurements and bronchoprovocation tests. We found a higher prevalence of respiratory symptoms in the exposed workers, whereas spirometric parameters were significantly lower. The prevalence of sensitisation to allergens and of bronchial hyperresponsivenss (BHR) did not differ significantly between the groups. The prevalence of asthma was also similar in both groups (8.0 % vs. 6.4 %; P=0.540). Work-relatedness of symptoms was reported by all asthmatic tea workers and by no control with asthma. Significant work-related changes in PEFR diurnal variations and in non-specific BHR, suggesting allergic OA, were found in one tea worker with asthma (1.6 %). No specific workplace agent causing OA in the affected subject was identified. None of the tea workers with asthma met the criteria for medical case definition of the reactive airway dysfunction syndrome (RADS). Our data confirm workplace exposure to herbal and fruit tea dust as a risk factor for OA. Minov J, et al. KEY WORDS: bronchial provocation tests, peak expiratory flow rate, skin prick test

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Section: Discussionmentioning

confidence: 99%

Occupational Asthma in Subjects Occupationally Exposed to Herbal and Fruit Tea Dust

Минов¹,

Karadžinska-Bislimovska²,

Vasilevska

et al. 2007

Archives of Industrial Hygiene and Toxicology

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“…Although green tea catechins have the intensive activity to reduce membrane fluidity, it is presumed that there is no possibility for catechins, especially the more active gallate esters, to show unwanted actions in vivo because of metabolic conjugation in addition to low bioavailability. In the literature, the suspected adverse effect of catechins has been found in only one report suggesting that EGCG is a potent causative agent for asthma of some workers in green tea factories [37].…”

Section: Discussionmentioning

confidence: 99%

Effects of Green Tea Catechins on Membrane Fluidity

Tsuchiya¹

1999

Pharmacology

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Catechins originating from green tea have been used in plaque inhibition for caries prevention and treatment for liver damage because of their antibacterial activity against cariogenic bacteria and protective activity on hepatic cells. The effects of catechins on membrane fluidity were studied by a fluorescence polarization method using liposomes prepared with dipalmitoylphosphatidylcholine and dioleoylphosphatidylcholine to assess their pharmacological mechanism at μmol/l levels found in human body fluids after clinical application. All eight catechins tested, ranging from 1 to 1,000 μmol/l, significantly reduced membrane fluidity in both hydrophilic and hydrophobic regions of lipid bilayers. Catechin gallate esters were superior in fluidity reduction to the corresponding nonesters. The fluidity-reducing degree was different between the cis and trans forms, suggesting the stereospecific activity of catechins. A reference antiplaque agent, chlorhexidine, similarly reduced membrane fluidity at the antibacterial concentration. (+)-Catechin (250 μmol/l) and (–)-epigallocatechin gallate (2.5 μmol/l) significantly prevented the membrane fluidization induced by hepatotoxic chloroform. These results indicate that the reduction in membrane fluidity is responsible for the antiplaque and hepatoprotective effects of green tea catechins.

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“…The majority of Japanese are familiar with adverse effects as well as the beneficial ones of tea through daily life experience, but formal reports on adverse effects have not been published except for one on green tea-induced asthma. 28) Although it has not been published, a phase I study with 10 volunteers (5 male research staff members and 5 nurses at Aichi Cancer Center), where 6 capsules per day for 3 months were administered, was conducted in 1994 before this phase II study. Blood pressure was taken and blood tests (urea nitrogen, creatinine, uric acid, glucose, total cholesterol, HDL cholesterol, triglyceride, γ-GTP, GOT, GPT, LDH, Fe, total iron binding capacity, saturation % of Fe, white blood cell count, red blood cell count, hemoglobin, hematocrit, and platelet count; pepsinogens I and II were not measured) were administered 4 times; at the start of intake, 6 weeks after, at the end of intake (3 months after the start), and 6 weeks after the end of intake.…”

Section: Discussionmentioning

confidence: 99%

Tea Polyphenol Intake and Changes in Serum Pepsinogen Levels

Hamajima

Tajima

Tominaga

et al. 1999

Japanese Journal of Cancer Research

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Following a phase I study, a phase II study was conducted to evaluate the effects of two different doses of tea polyphenols on serum pepsinogen levels. Subjects were patients aged 40 to 69 years who had undergone gastroscopy between 1995 and 1997 at Aichi Cancer Center Hospital, and had been found to have no disease requiring medication. Those with pepsinogen I < < < <70 ng/ml and pepsinogen I/II ratio < < < <6 were included in this study. Capsules containing 100 mg of tea polyphenols were administered for 1 year: 1 capsule per day for 101 patients (42 males and 59 females), and 6 capsules (equivalent to 10 cups) per day for 83 patients (30 males and 53 females). The enrollment of the 1 capsule group preceded that of the 6 capsule group, in which re-participation was allowed. Blood samples were obtained 1 year after participation from 86 participants of the 1 capsule group and 77 participants (43 new participants and 34 re-participants) of the 6 capsule group. The compliance in polyphenol capsule intake ranged from 11.4 to 105.7% (87.6% on average) of the scheduled amount for the 1 capsule group and 3.2 to 112.3% (77.8% on average) for the 6 capsule group. No serious polyphenol-related adverse effects were reported. The difference in pepsinogen I between before and after 1 year intake of the polyphenol was 3.1 ng/ml for the 43 participants of the 6 capsule group, but 3.5 ng/ml for the 1 capsule group. The mean pepsinogen I/ II ratio for the 43 participants increased from 2.37 by 0.08. This increase was not larger than that for the 1 capsule group (from 2.61 by 0.11). Among 34 participants in both interventions, no significant increase in pepsinogen I and I/II ratio for the 6 capsule intervention was observed. This result suggests that additional polyphenol intake for 1 year in Japanese does not improve pepsinogen levels, which are considered to reflect stomach atrophy, a high-risk condition for stomach cancer.

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Epigallocatechin Gallate-Induced Histamine Release in Patients with Green Tea-Induced Asthma

Cited by 28 publications

References 13 publications

Occupational Asthma in Subjects Occupationally Exposed to Herbal and Fruit Tea Dust

Occupational Asthma in Subjects Occupationally Exposed to Herbal and Fruit Tea Dust

Effects of Green Tea Catechins on Membrane Fluidity

Tea Polyphenol Intake and Changes in Serum Pepsinogen Levels

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