Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia: A double-blind, randomized and placebo-controlled clinical study

Shi, Dandan; Guo, Jinping; Zhou, Lean; Wang, N.

doi:10.1111/jcpt.12597

Cited by 30 publications

(26 citation statements)

References 24 publications

(31 reference statements)

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“…Previous studies with plant-derived compounds as resveratrol demonstrate anti-hypertensive effects and reduced oxidative stress [ 45 46 ]. A triterpenoid, celastrol [ 47 ] and Epigallocatechin gallate (EGCG) from green tea [ 48 ] were found to enhance the effects of oral nifedipine, common anti-hypertensive drug in PE.…”

Section: Discussionmentioning

confidence: 99%

Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension

Wang

Huang

Yang

et al. 2018

Korean J Physiol Pharmacol

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Pre-eclampsia (PE) is a pregnancy disorder that is characterised by severe hypertension and increased risks of foetal and maternal mortality. The aetiology of PE not completely understood; however, maternal nutrition and oxidative stress play important roles in the development of hypertension. The treatment options for PE are currently limited to anti-hypertensive drugs. Punicalagin, a polyphenol present in pomegranate juice, has a range of bioactive properties. The effects of supplementation with punicalagin on angiogenesis and oxidative stress in pregnant rats with induced hypertension were investigated. The pregnant rats were randomly divided into five experimental groups (n=12 per group). Hypertension was induced using an oral dose of NG-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg/day) on days 14–19 of pregnancy. Punicalagin (25, 50 or 100 mg/kg) was given orally on days 14–21 of pregnancy. Punicalagin treatment at the tested doses significantly reduced diastolic, systolic, and mean arterial blood pressure in L-NAME treated rats from day 14. Punicalagin also restored angiogenic balance by increasing the expression of vascular endothelial growth factor and downregulating vascular endothelial growth factor receptor-1/fms-like tyrosine kinase-1. Punicalagin, significantly increased the placental nitric oxide levels as compared to PE group. The increased levels of oxidative stress in rats with PE were markedly decreased by treatment with punicalagin. Punicalagin at the tested doses markedly (p<0.05) enhanced the placental antioxidant capacity in L-NAME-treated rats. The raised catalase activity observed following L-NAME induction was significantly (p<0.05) and restored to normal activity levels in punicalagin treatment. Further, 100 mg dose of punicalagin exhibited higher protective effects as compared to lower doses of 25 and 50 mg. This study shows that supplementation with punicalagin decreased blood pressure and oxidative stress and restored angiogenic balance in pregnant rats with induced PE.

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Section: Discussionmentioning

confidence: 99%

Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension

Wang

Huang

Yang

et al. 2018

Korean J Physiol Pharmacol

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“…Thus, EGCG‐enriched tea drinks do not appear to be a promising maintenance intervention in women with advanced ovarian cancer after standard treatment . EGCG in improving the efficacy of oral nifedipine for treating pregnancy‐induced severe pre‐eclampsia is safe and effective . And single administration of EGCG may also significantly affect the pharmacokinetics of Nadolol …”

Section: Natural Polyphenols Nrf2 Activators In Multiple Disease Modelsmentioning

confidence: 99%

“…[82] EGCG in improving the efficacy of oral nifedipine for treating pregnancy-induced severe pre-eclampsia is safe and effective. [83] And single administration of EGCG may also significantly affect the pharmacokinetics of Nadolol. [84] Gallic acid (GA, 14), a natural polyphenol, has been shown to have a variety of health-promoting effects.…”

Section: Other Polyphenolsmentioning

confidence: 99%

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Zhou

Jiang

et al. 2019

Chemistry & Biodiversity

142

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The Keap1‐Nrf2/ARE signaling pathway is an important defense system against exogenous and endogenous oxidative stress injury. The dysregulation of the signaling pathway is associated with many diseases, such as cancer, diabetes, and respiratory diseases. Over the years, a wide range of natural products has provided sufficient resources for the discovery of potential therapeutic drugs. Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1‐Nrf2 protein–protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway. In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1‐Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered. In this view, we summarize the research status of natural polyphenols that have been found with apparent Nrf2 activation and their action modes. On the whole, this review may guide the design of novel Keap1‐Nrf2 activator.

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“…EGCG is the most abundant catechin in green tea and has a variety of biological activities [ 12 ]. A study suggested that EGCG can improve the treatment efficacy of oral nifedipine against severe PE [ 13 ], and EGCG treatment can markedly inhibit the expression of HMGB1 induced by balloon injury [ 16 ]. EGCG can alleviate lung injury by inhibiting the expression of HMGB1 and RAGE [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Epigallocatechin gallate (EGCG), the most abundant and bioactive polyphenol in green tea, has been demonstrated to possess many biological functions [ 12 ]. A study proved that EGCG could promote the treatment efficacy of oral nifedipine against severe PE [ 13 ]. Chae et al proved that EGCG could inhibit Ang II-induced elevation of vascular cell adhesion molecule 1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin Gallate (EGCG) Improves Anti-Angiogenic State, Cell Viability, and Hypoxia-Induced Endothelial Dysfunction by Downregulating High Mobility Group Box 1 (HMGB1) in Preeclampsia

et al. 2020

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Background Preeclampsia (PE) is a serious complication of pregnancy with no effective therapy. This study assessed whether epigallocatechin gallate (EGCG) could reduce the production of anti-angiogenic factors, improve cell viability, and suppress endothelial dysfunction in vitro via regulating high mobility group box 1 (HMGB1) in preeclampsia. Material/Methods Human umbilical vein endothelial cells (HUVECs) grown in conditioned medium from hypoxic JEG-3 cells were used to investigate the effects of EGCG on anti-angiogenic state, cell viability, and markers of endothelial dysfunction. To confirm that EGCG exerted its effects via HMGB1, we also examined the impact of EGCG on anti-angiogenic state, cell viability, and endothelial dysfunction following HMGB1 treatment in vitro . Results EGCG inhibited HMGB1 expression in hypoxic trophoblast cells in a dose-dependent manner. In addition, EGCG relieved anti-angiogenic state and endothelial dysfunction in hypoxic trophoblast cells by downregulating HMGB1. Moreover, EGCG dose-dependently promoted cell proliferation by downregulating HMGB1. Conclusions Taken together, our data show the protective role of EGCG in preeclampsia and revealed EGCG-mediated effects on the production of anti-angiogenic factors, cell viability, and endothelial dysfunction through downregulating HMGB1. These observations suggest that EGCG is a novel therapeutic candidate for preeclampsia.

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Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia: A double-blind, randomized and placebo-controlled clinical study

Abstract: EGCG is both safe and effective in enhancing treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia, but formal validation is required prior to its recommendation for use outside of clinical trials.

Cited by 30 publications

References 24 publications

Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension

Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Epigallocatechin Gallate (EGCG) Improves Anti-Angiogenic State, Cell Viability, and Hypoxia-Induced Endothelial Dysfunction by Downregulating High Mobility Group Box 1 (HMGB1) in Preeclampsia

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