(−)-Epigallocatechin gallate (EGCG)-nanoethosomes as a transdermal delivery system for docetaxel to treat implanted human melanoma cell tumors in mice

Liao, Bingwu; Hao, Ying; Yu, Chunjing; Fan, Zhaoyang; Zhang, Weihua; Shi, John; Ying, Hua‐Zhong; Ravichandran, Nagaiya; Xu, Yong-Quan; Yin, Jing; Jiang, Yongwen; Du, Qizhen

doi:10.1016/j.ijpharm.2016.08.038

Cited by 36 publications

(19 citation statements)

References 36 publications

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“…Besides, EGCG-DHA (docosahexaenoic) ester, a lipophilic derivative of EGCG, shows improved anti-oxidative effects compared to EGCG, and suppresses colon carcinogenesis in mice [112,113]. In the last decade, many studies were carried out using EGCG-loaded nanoparticles including FA-NPS-PEG and FA-PEG-NPS (epigallocatechin gallate-β-lactoglobulin nanoparticles), EGCG-SLN (solid lipid nanoparticle), DT-EGCG-nanoethosomes, FCS-EGCG-NPs (chitosan coated nanoparticles), EGCG-dispersed selenium nanoparticles, 198 AuNP-EGCg (gold nanoparticles), EGCG-loaded microspheres (EGCG/MS), and FCMPs (ferritin-chitosan Maillard reaction products) [6,110,[114][115][116][117][118][119][120][121]. These EGCG nanoparticles can improve the targeting ability and efficacy of EGCG, which greatly promote the clinical application and development of EGCG analogs.…”

Section: Epigallocatechin Gallate (Egcg)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Epigallocatechin Gallate (Egcg)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…A study by Liao et al showed that transdermal delivery docetaxel loaded in EGCG-nanoethosomes reduced the tumour volume. The nanoethosomes allow transdermal delivery of flavonoids to melanoma cancer cells [ 33 ]. The Tang et al study showed that EGCG nanoparticles (chitin-laden honokiol) inhibited the proliferation of HepG2 cancer cell cells by inhibiting cells in the G2/M phase and reducing the potential of the mitochondrial membrane [ 34 ].…”

Section: Epigallocatechin-3-gallate (Egcg)mentioning

confidence: 99%

“…The Chaurasia et al study has described tumour suppression in BALB/c mice bearing colon-26 cells. Both naringenin-encapsulated soluthin-maltodextrin nanoparticles and EE-naringenin improve bioavailability and have a cytotoxic effect against colorectal cancer cells [ 32 , 33 ]. The Fuster et al study reported that naringenin loaded in silk fibroin nanoparticles had anticancer potential for treatment of cervical cancer HeLa cells [ 78 ] ( Table 6 ).…”

Section: Naringeninmentioning

confidence: 99%

Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy

2020

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Flavonoids, a ubiquitous group of naturally occurring polyphenolic compounds, have recently gained importance as anticancer agents. Unfortunately, due to low solubility, absorption, and rapid metabolism of dietary flavonoids, their anticancer potential is not sufficient. Nanocarriers can improve the bioavailability of flavonoids. In this review we aimed to evaluate studies on the anticancer activity of flavonoid nanoparticles. A review of English language articles published until 30 June 2020 was conducted, using PubMed (including MEDLINE), CINAHL Plus, Cochrane, and Web of Science data. Most studies determining the anticancer properties of flavonoid nanoparticles are preclinical. The potential anticancer activity focuses mainly on MCF-7 breast cancer cells, A549 lung cancer cells, HepG2 liver cancer cells, and melanoma cells. The flavonoid nanoparticles can also support the anti-tumour effect of drugs used in cancer therapy by enhancing the anti-tumour effect or reducing the systemic toxicity of drugs.

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“…Several flavonoids have been studied for their ability to act either as positive or negative regulators in melanogenesis; however, the exact mechanisms of how they exert their anti-proliferative and anti-metastatic properties are not fully elucidated [28]. Nevertheless, there is encouraging evidence on the beneficial effects of several flavonoids by their conjunction with nanoparticles for their targeted delivery in in vitro and in vivo models of melanoma [29,30,31,32]. Hence, PZDHA could potentially act as a new and promising approach in melanoma treatment.…”

Section: Discussionmentioning

confidence: 99%

Novel Docosahexaenoic Acid Ester of Phloridzin Inhibits Proliferation and Triggers Apoptosis in an In Vitro Model of Skin Cancer

et al. 2018

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Skin cancer is among the most common cancer types accompanied by rapidly increasing incidence rates, thus making the development of more efficient therapeutic approaches a necessity. Recent studies have revealed the potential role of decosahexaenoic acid ester of phloridzin (PZDHA) in suppressing proliferation of liver, breast, and blood cancer cell lines. In the present study, we investigated the cytotoxic potential of PZDHA in an in vitro model of skin cancer consisting of melanoma (A375), epidermoid carcinoma (A431), and non-tumorigenic (HaCaT) cell lines. Decosahexaenoic acid ester of phloridzin led to increased cytotoxicity in all cell lines as revealed by cell viability assays. However, growth inhibition and induction of both apoptosis and necrosis was more evident in melanoma (A375) and epidermoid carcinoma (A431) cells, whereas non-tumorigenic keratinocytes (HaCaT) appeared to be more resistant as detected by flow cytometry. More specifically, PZDHA-induced cell cycle growth arrest at the G2/M phase in A375 and A431 cells in contrast to HaCaT cells, which were growth arrested at the G0/G1 phase. Elevated intracellular generation of reactive oxygen species ROS was detected in all cell lines. Overall, our findings support the potential of PZDHA as a novel therapeutic means against human skin cancer.

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(−)-Epigallocatechin gallate (EGCG)-nanoethosomes as a transdermal delivery system for docetaxel to treat implanted human melanoma cell tumors in mice

Cited by 36 publications

References 36 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy

Novel Docosahexaenoic Acid Ester of Phloridzin Inhibits Proliferation and Triggers Apoptosis in an In Vitro Model of Skin Cancer

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