Epigallocatechin gallate, cerebral blood flow parameters, cognitive performance and mood in healthy humans: a double‐blind, placebo‐controlled, crossover investigation

Abstract

David (2012) Epigallocatechin gallate, cerebral blood flow parameters, cognitive performance and mood in healthy humans: a double-blind, placebo-controlled, crossover investigation. Human Psychopharmacology: Clinical and Experimental, 27 (2 Northumbria University has developed Northumbria Research Link (NRL) to enable users to access the University's research output. Copyright © and moral rights for items on NRL are retained by the individual author(s) and/or other copyright owners. Single copies of full items can be reproduced, displayed or performed, and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided the authors, title and full bibliographic details are given, as well as a hyperlink and/or URL to the original metadata page. The content must not be changed in any way. Full items must not be sold commercially in any format or medium without formal permission of the copyright holder. The full policy is available online: http://nrl.northumbria.ac.uk/policies.html This document may differ from the final, published version of the research and has been made available online in accordance with publisher policies. To read and/or cite from the published version of the research, please visit the publisher's website (a subscription may be required.) RESULTS:During the post-dose task performance period the administration of 135 mg EGCG resulted in reduced CBF in the frontal cortex, as indexed by significantly lower concentrations of both oxygenated and total haemoglobin, in comparison to placebo. Heart rate was significantly reduced from pre-to post dose across all treatments. No significant differences were observed for the level of deoxygenated haemoglobin or on any of the cognitive performance/mood measures. CONCLUSIONS:These results demonstrate that a single dose of orally administered EGCG can modulate CBF parameters in healthy humans but that this is not associated with changes in cognitive performance or mood.

The potential role of fruit and vegetables in aspects of psychological well-being: a review of the literature and future directions

“…Antioxidants in FV may also be beneficial towards lowering inflammatory markers, which have been implicated in the onset of poor mental health including depression (29) . Although the relationship between antioxidant nutrients and psychological health is currently ambivalent, with some studies refuting the hypothesis (30)(31)(32) , a number of studies have provided evidence to support the link. For example, one CS study (29) demonstrated associations between the dietary intake of antioxidants and depressed mood in older adults, whereas another showed that concentrations of plasma carotenoids were associated with optimism (33) .…”

Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice

“…This effect appears to be dose-dependent, as the vasoconstrictive properties were only apparent at low doses (Shen et al, 2003). Wightman et al also found a reduced CBF in healthy volunteers after a single dose of 135 mg EGCG (Wightman et al, 2012). This low dose of EGCG resulted in decreased CBF in the frontal cortex during cognitive task performance (Wightman et al, 2012).…”

“…Wightman et al also found a reduced CBF in healthy volunteers after a single dose of 135 mg EGCG (Wightman et al, 2012). This low dose of EGCG resulted in decreased CBF in the frontal cortex during cognitive task performance (Wightman et al, 2012). Further research is necessary to explore these dosedependent effects and underlying mechanisms.…”

The mechanisms of action of flavonoids in the brain: Direct versus indirect effects

“…In addition to cocoa flavanols, there has been also interventions with the tea flavanol epigallocatechin gallate (EGCG) in young healthy volunteers reporting modulation in neuronal activity and cerebral blood flow (196)(197)(198). Furthermore, reports of MRI studies with anthocyanin-rich blueberries in both young and aged adults, revealed acute increases in CBF in specific regions of the brain, such as the occipital Table 2).…”