Epigallocatechin gallate-based nanoparticles with reactive oxygen species scavenging property for effective chronic periodontitis treatment

Zeng

et al. 2021

ACS Appl. Nano Mater.

Self Cite

Polyphenol-based hollow nanoparticles have exhibited intriguing properties in drug delivery, catalysis, and energy storage, and the open-mouthed (bowl-shaped) structure is supposed to improve the performance of the nanoparticles by increasing the accessibility of the inner surface and the cavity. Up to now, cationic polymers, metal ions, and sacrificial templates are generally applied in the preparation of the polyphenol-based hollow nanoparticle, and these polyphenols are usually confined to tannin acid and lignin. Seeking for the novel assembly strategy with a wide selection of polyphenolic compounds would open a new horizon for the design, preparation, and applications of polyphenol-based functional materials. In this study, polyphenol nanoparticles with bowl-shaped structure were efficiently prepared through the polymerization-induced self-assembly of tea polyphenols in a few minutes. The formation mechanism was proposed on the basis of a series of TEM images revealing the morphology evolution process. The nanoparticles with good stability in carbonization process are candidates for bowl-shaped carbon spheres. These nanoparticles exhibit potent radical scavenging capacity, anticancer activity, high adsorption capacity of guest molecules (DOX and methylene blue), and pH-dependent release property, with promising use as active delivery systems. Moreover, the present polyphenol assembly strategy provides inspiration for fundamental studies on structure–property–function relationship of polyphenol-based materials.

Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Polymerization-Induced Self-Assembly of Tea Polyphenols into Open-Mouthed Nanoparticles for Active Delivery Systems and Stable Carbon Bowls

Zeng

et al. 2021

ACS Appl. Nano Mater.

Self Cite

“…However, like other polyphenolic compounds, issues on its poor stability and low operational bioactivities lead to the unsatisfactory effect of tea polyphenol. Since previous methods of encapsulating tea polyphenol require tedious procedure, Tian et al (2021) have developed a one-step polyphenolic condensation reaction that functionalized EGCG, the green tea derivative nanoparticles. The potent antioxidant capacity of EGCG-based nanoparticles was found to improve the chemical stability of epigallocatechin gallate.…”

Section: Nanoparticles Mediated Delivery In Managing Periodontal Infl...mentioning

confidence: 99%

Therapeutic Potential of Polyphenol and Nanoparticles Mediated Delivery in Periodontal Inflammation: A Review of Current Trends and Future Perspectives

et al. 2022

Periodontitis is an oral inflammatory process involving the periodontium, which is mainly caused by the invasion of periodontopathogenic microorganisms that results in gingival connective tissue and alveolar bone destruction. Metabolic products of the oral pathogens and the associated host immune and inflammatory responses triggered are responsible for the local tissue destruction. Numerous studies in the past decades have demonstrated that natural polyphenols are capable of modulating the host inflammatory responses by targeting multiple inflammatory components. The proposed mechanism by which polyphenolic compounds exert their great potential is by regulating the immune cell, proinflammatory cytokines synthesis and gene expression. However, due to its low absorption and bioavailability, the beneficial effects of these substances are very limited and it hampers their use as a therapeutic agent. To address these limitations, targeted delivery systems by nanoencapsulation techniques have been explored in recent years. Nanoencapsulation of polyphenolic compounds with different carriers is an efficient and promising approach to boost their bioavailability, increase the efficiency and reduce the degradability of natural polyphenols. In this review, we focus on the effects of different polyphenolic substances in periodontal inflammation and to explore the pharmaceutical significance of polyphenol-loaded nanoparticles in controlling periodontitis, which may be useful for further enhancement of their efficacy as therapeutic agents for periodontal disease.

“…Moreover, phytochemicals themselves could also be functionalized into part of the nanoparticle to facilitate their uptake across the BBB and, upon release inside the brain microenvironment, utilize the therapeutical nature of the phytochemical for treatment. One study disguised EGCG by functionalized EGCG; EGCG nanoparticles (NPs) were developed via a one-step polyphenolic condensation reaction ( 105 ).…”

Section: Nanodelivery Systems Provide Solutions For Phytochemical Bra...mentioning

confidence: 99%

The Phytochemical Potential for Brain Disease Therapy and the Possible Nanodelivery Solutions for Brain Access

Liu

et al. 2022

Front. Oncol.

Plant-derived phytochemicals have gifted humans with vast therapeutic potentials. Yet, the unique features of the blood–brain barrier significantly limit their accession to the target tissue and thus clinical translation in brain disease treatment. Herein, we explore the medicinal outcomes of both the rare examples of phytochemicals that can easily translocate across the blood–brain barrier and most of the phytochemicals that were reported with brain therapeutic effects, but a bizarre amount of dosage is required due to their chemical nature. Lastly, we offer the nanodelivery platform that is capable of optimizing the targeted delivery and application of the non-permeable phytochemicals as well as utilizing the permeable phytochemicals for boosting novel applications of nanodelivery toward brain therapies.