Epigallocatechin 3-gallate inhibits the plasma membrane Ca2+-ATPase: effects on calcium homeostasis

Rinaldi, Débora E.; Ontiveros, Mallku Q.; Saffioti, Nicolás A.; Vigil, Maximiliano A.; Mangialavori, Irene C.; Rossi, Rolando; Rossi, Juan Pablo F.C.; Espelt, María V.; Ferreira-Gomes, Mariela

doi:10.1016/j.heliyon.2021.e06337

Cited by 4 publications

(2 citation statements)

References 70 publications

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“…Moreover, EGCG induces an increase in intracellular Ca 2+ in prostate cancer cells by a multistep mechanism [ 179 ]. Recent research has found that, in human embryonic kidney cells, the effects of EGCG on Ca 2+ homeostasis may involve the inhibition of plasma membrane Ca 2+ -ATPase, among other mechanisms [ 180 ].…”

Section: Catechins and Their Regulation Of The Metabolic Network Invo...mentioning

confidence: 99%

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

Chen

Zhang

Lin

et al. 2022

IJMS

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Mitochondria are the main sites for oxidative phosphorylation and synthesis of adenosine triphosphate in cells, and are known as cellular power factories. The phrase “secondary mitochondrial diseases” essentially refers to any abnormal mitochondrial function other than primary mitochondrial diseases, i.e., the process caused by the genes encoding the electron transport chain (ETC) proteins directly or impacting the production of the machinery needed for ETC. Mitochondrial diseases can cause adenosine triphosphate (ATP) synthesis disorder, an increase in oxygen free radicals, and intracellular redox imbalance. It can also induce apoptosis and, eventually, multi-system damage, which leads to neurodegenerative disease. The catechin compounds rich in tea have attracted much attention due to their effective antioxidant activity. Catechins, especially acetylated catechins such as epicatechin gallate (ECG) and epigallocatechin gallate (EGCG), are able to protect mitochondria from reactive oxygen species. This review focuses on the role of catechins in regulating cell homeostasis, in which catechins act as a free radical scavenger and metal ion chelator, their protective mechanism on mitochondria, and the protective effect of catechins on mitochondrial deoxyribonucleic acid (DNA). This review highlights catechins and their effects on mitochondrial functional metabolic networks: regulating mitochondrial function and biogenesis, improving insulin resistance, regulating intracellular calcium homeostasis, and regulating epigenetic processes. Finally, the indirect beneficial effects of catechins on mitochondrial diseases are also illustrated by the warburg and the apoptosis effect. Some possible mechanisms are shown graphically. In addition, the bioavailability of catechins and peracetylated-catechins, free radical scavenging activity, mitochondrial activation ability of the high-molecular-weight polyphenol, and the mitochondrial activation factor were also discussed.

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Section: Catechins and Their Regulation Of The Metabolic Network Invo...mentioning

confidence: 99%

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

Chen

Zhang

Lin

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…The sources for Table 2 are refs. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. The structural images were created using CHEMDRAW 20.0 (PerkinElmer, Cambridge, MA, USA).…”

Section: Introductionmentioning

confidence: 99%

Physiological Effects of Green-Colored Food-Derived Bioactive Compounds on Cardiovascular and Metabolic Diseases

et al. 2022

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Cardiovascular and metabolic diseases are a leading cause of death worldwide. Epidemiological studies strongly highlight various benefits of consuming colorful fruits and vegetables in everyday life. In this review, we aimed to revisit previous studies conducted in the last few decades regarding green-colored foods and their bioactive compounds in consideration of treating and/or preventing cardiovascular and metabolic diseases. This review draws a comprehensive summary and assessment of research on the physiological effects of various bioactive compounds, mainly polyphenols, derived from green-colored fruits and vegetables. In particular, their health-beneficial effects, including antioxidant, anti-inflammatory, anti-diabetic, anti-obesity, cardioprotective, and lipid-lowering properties, will be discussed. Furthermore, the bioavailability and significance of action of these bioactive compounds on cardiovascular and metabolic diseases will be discussed in detail.

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Oligomeric Proanthocyanidins Confer Cold Tolerance in Rice through Maintaining Energy Homeostasis

Feng

et al. 2022

Antioxidants

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Oligomeric proanthocyanidins (OPCs) are abundant polyphenols found in foods and botanicals that benefit human health, but our understanding of the functions of OPCs in rice plants is limited, particularly under cold stress. Two rice genotypes, named Zhongzao39 (ZZ39) and its recombinant inbred line RIL82, were subjected to cold stress. More damage was caused to RIL82 by cold stress than to ZZ39 plants. Transcriptome analysis suggested that OPCs were involved in regulating cold tolerance in the two genotypes. A greater increase in OPCs content was detected in ZZ39 than in RIL82 plants under cold stress compared to their respective controls. Exogenous OPCs alleviated cold damage of rice plants by increasing antioxidant capacity. ATPase activity was higher and poly (ADP-ribose) polymerase (PARP) activity was lower under cold stress in ZZ39 than in RIL82 plants. Importantly, improvements in cold tolerance were observed in plants treated with the OPCs and 3-aminobenzamide (PARP inhibitor, 3ab) combination compared to the seedling plants treated with H2O, OPCs, or 3ab alone. Therefore, OPCs increased ATPase activity and inhibited PARP activity to provide sufficient energy for rice seedling plants to develop antioxidant capacity against cold stress.

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Epigallocatechin 3-gallate inhibits the plasma membrane Ca2+-ATPase: effects on calcium homeostasis

Cited by 4 publications

References 70 publications

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

Physiological Effects of Green-Colored Food-Derived Bioactive Compounds on Cardiovascular and Metabolic Diseases

Oligomeric Proanthocyanidins Confer Cold Tolerance in Rice through Maintaining Energy Homeostasis

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