2014
DOI: 10.1016/j.exger.2013.11.011
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Epigallocatechin-3-gallate improves plantaris muscle recovery after disuse in aged rats

Abstract: Aging exacerbates muscle loss and slows the recovery of muscle mass and function after disuse. In this study we investigated the potential that epigallocatechin gallate (EGCg), an abundant catechin in green tea, would reduce signaling for apoptosis and promote skeletal muscle recovery in the fast plantaris muscle and the slow soleus muscle after hindlimb unloading (HLS) in senescent animals. Fischer 344 × Brown Norway inbred rats (age 34 mo.) received either EGCg (50 mg/kg body weight), or water daily by gavag… Show more

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Cited by 52 publications
(72 citation statements)
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“…An abrupt decrease in physical activity leading to forced bedrest or hospitalization exacerbates muscle wasting in both middle aged (Arentson-Lantz et al, 2016) and elderly persons (Pisot et al, 2016), and significantly exacerbates their health problems (Inouye et al, 1993; Pisani et al, 2016). Furthermore, aging attenuates or delays recovery of muscle mass and function after disuse in elderly humans and aged animal models (Alway et al, 2014a; Hao et al, 2011; Pisot et al, 2016; Tanner et al, 2015; White et al, 2015; Zarzhevsky et al, 2001). …”
Section: Introductionmentioning
confidence: 99%
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“…An abrupt decrease in physical activity leading to forced bedrest or hospitalization exacerbates muscle wasting in both middle aged (Arentson-Lantz et al, 2016) and elderly persons (Pisot et al, 2016), and significantly exacerbates their health problems (Inouye et al, 1993; Pisani et al, 2016). Furthermore, aging attenuates or delays recovery of muscle mass and function after disuse in elderly humans and aged animal models (Alway et al, 2014a; Hao et al, 2011; Pisot et al, 2016; Tanner et al, 2015; White et al, 2015; Zarzhevsky et al, 2001). …”
Section: Introductionmentioning
confidence: 99%
“…However, there is evidence that apoptotic signaling in myonuclei and satellite cells may have a role in regulating muscle loss in response to forced disuse (Alway et al, 2014a; Alway et al, 2015; Alway et al, 2011; Alway et al, 2014b; Hao et al, 2011; Marzetti et al, 2013a; Marzetti et al, 2012; Wang et al, 2011). Loss of autophagy signaling in satellite cells/muscle stem cells in aging muscle (Garcia-Prat et al, 2016; Sousa-Victor et al, 2014) might increase the susceptibility of satellite cells for apoptosis and reduce the regenerative capacity of muscle.…”
Section: Introductionmentioning
confidence: 99%
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