Epigallocatechin-3-gallate (EGCG) protects the oocytes from methyl parathion-induced cytoplasmic deformities by suppressing oxidative and endoplasmic reticulum stress

Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids

“… S/N Flavonoids Organs/animal Target Disease condition References 1 Acacetin Liver ATF6 and CHOP Non-alcoholic fatty liver disease Jiang et al (2023) 2 Apigenin Liver and visceral fats p-PERK, GRP78, p-eIF2a, and CHOP Obesity Wu et al (2021) 3 Baicalein Spinal cord GRP78, ATF4, CHOP, and CASP12 Ischemia-reperfusion Injury Wu et al (2020) 5 EGCG Brain GRP78, CHOP, cleaved-caspase-12 and caspase-3. Alzheimer's disease Du et al (2018) Ovaries GRP78 and XBP1 Reproductive system disorder Hegde et al (2020) 6 Fisetin Liver ROS, GRP78 and CHOP NAFLD Dai et al (2022) Heart PERK, eIF2α, IRE1, XBP1 and CHOP Cardiomyopathy Ge et al (2019) 8 Hyperoside Heart BiP, CHOP and Nrf2 Cardiac ischemia-reperfusion injury Hou et al (2016) 9 Icariin Spinal cord ATF6, IRE1α, GRP78, XBP1 and eIF2α Neuronal apoptosis ...…”

Epigallocatechin 3‐gallate improves the quality of bull semen cryopreservation

“…Epigallocatechin-3-gallate (EGCG), a polyphenolic substance, has a wide range of biological activities, such as inhibiting cell apoptosis that is caused by hypoxia (Wang et al, 2018), inhibiting bacterial virulence, reducing the bacterial invasion of host cells (Tsou et al, 2017) and ameliorating the effects of oxidative stress through an anti-inflammatory pathway (Basiricò et al, 2019), as well as inhibiting the oxidative stress of the endoplasmic reticulum to protect oocytes from methylation (Hegde et al, 2020). As an antioxidant, it was recently observed that the addition of EGCG could improve the fertilisation efficiency of boar sperm by improving the anti-oxidant capacity (Gadani et al, 2017).…”