Epigallocatechin-3-gallate attenuates cyclophosphamide-induced damage in mouse ovarian tissue via suppressing inflammation, apoptosis, and expression of phosphorylated Akt, FOXO3a and rpS6

Barberino, Ricássio de Sousa; Lins, T.L.B.G.; Monte, Alane Pains Oliveira do; Silva, Regina Lucia S.; Andrade, Kíscyla O.; Campinho, D.S.P.; Palheta, Raimundo C.; Smitz, Johan E.J.; Matos, Maria Helena Tavares de

doi:10.1016/j.reprotox.2022.08.010

Cited by 5 publications

(1 citation statement)

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“…Immunosuppression is one of the side effects of CY, and patients are susceptible to invasive fungal infections, which can be life-threatening [2]. In recent years, many naturally active substances with low toxic effects on the host have been proven to repair the immune deficiency induced by CY [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice

Zhang

Tang

Cai

et al. 2023

Oxidative Medicine and Cellular Longevity

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To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1. The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY. COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions. Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway. Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function. This study suggests that COP1 may provide an alternative strategy for alleviating chemotherapy-induced immunosuppression.

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