Epigallocatechin-3-gallate and resveratrol attenuate hydrogen peroxide induced damage in neuronal cells

Cosar, Meltem Yilmaz; Erdoğan, Mehmet; Yılmaz, Özlem

doi:10.4149/bll_2023_033

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…It exhibits health-promoting effects including prevention and/or treatment of neurodegenerative disorders modulating the Nrf2 pathway and stress resilience vitagenes [127]. It was also revealed that resveratrol protects cochlear cells from cisplatin-induced ototoxicity [128] and neuronal cells from hydrogen peroxide-induced oxidative damage dose-dependently [129]. Consistent with hormesis, in vitro studies have shown that a low dose (50 µM) of resveratrol significantly attenuates CoCl2-induced cochlear hair cell damage via activation of Sirt1, which deacetylates NF-κB [130].…”

Section: Stilbenementioning

confidence: 99%

Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics

Osakabe,

Modafferi,

Ontario

et al. 2023

Medicina

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There is substantial experimental and clinical interest in providing effective ways to both prevent and slow the onset of hearing loss. Auditory hair cells, which occur along the basilar membrane of the cochlea, often lose functionality due to age-related biological alterations, as well as from exposure to high decibel sounds affecting a diminished/damaged auditory sensitivity. Hearing loss is also seen to take place due to neuronal degeneration before or following hair cell destruction/loss. A strategy is necessary to protect hair cells and XIII cranial/auditory nerve cells prior to injury and throughout aging. Within this context, it was proposed that cochlea neural stem cells may be protected from such aging and environmental/noise insults via the ingestion of protective dietary supplements. Of particular importance is that these studies typically display a hormetic-like biphasic dose–response pattern that prevents the occurrence of auditory cell damage induced by various model chemical toxins, such as cisplatin. Likewise, the hormetic dose–response also enhances the occurrence of cochlear neural cell viability, proliferation, and differentiation. These findings are particularly important since they confirmed a strong dose dependency of the significant beneficial effects (which is biphasic), whilst having a low-dose beneficial response, whereas extensive exposures may become ineffective and/or potentially harmful. According to hormesis, phytochemicals including polyphenols exhibit biphasic dose–response effects activating low-dose antioxidant signaling pathways, resulting in the upregulation of vitagenes, a group of genes involved in preserving cellular homeostasis during stressful conditions. Modulation of the vitagene network through polyphenols increases cellular resilience mechanisms, thus impacting neurological disorder pathophysiology. Here, we aimed to explore polyphenols targeting the NF-E2-related factor 2 (Nrf2) pathway to neuroprotective and therapeutic strategies that can potentially reduce oxidative stress and inflammation, thus preventing auditory hair cell and XIII cranial/auditory nerve cell degeneration. Furthermore, we explored techniques to enhance their bioavailability and efficacy.

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