Epigallocatechin-3-gallate ameliorates radiation-induced acute skin damage in breast cancer patients undergoing adjuvant radiotherapy

Zhu, Wei; Li, Jia; Chen, Guanxuan; Zhao, Hanxi; Sun, Xuejun; Meng, Xiangjiao; Zhao, Xianguang; Xing, Ligang; Yu, Jinming; Zheng, Min

doi:10.18632/oncotarget.9495

Cited by 45 publications

(32 citation statements)

References 25 publications

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“…The adverse reactions of eGcG were found to be mild in the dose expansion test of patients with estrogen receptor-negative breast cancer, and the main adverse reactions included nausea, heartburn, abdominal pain, headache, dizziness and myalgia (59). In stage iii non-small cell lung cancer treated with radiation and chemotherapy, and patients with breast cancer with neoadjuvant radiotherapy, giving eGcG was reported to be safe, and eGcG prevented radiation and chemotherapy injury, playing a positive role in promoting tissue repair (60,61). These clinical trials of eGcG have shown its low toxicity and wide margin of safety.…”

Section: Discussionmentioning

confidence: 99%

Anti‑glycolipid disorder effect of epigallocatechin‑3‑gallate on high‑fat diet and STZ‑induced T2DM in mice

et al. 2020

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epigallocatechin-3-gallate (eGcG) is beneficial for inhibiting dyslipidemia and reducing hyperlipidemic risk. The purpose of the present study was to investigate the glycolipid regulatory effects and potential mechanisms of eGcG in a high-fat diet and streptozotocin-induced type 2 diabetes mellitus (T2dM) mouse model. The results demonstrated that eGcG can decrease blood glucose levels and increase insulin resistance in T2dM mice. in addition, eGcG can regulate serum lipid levels, including those of total cholesterol, triglyceride and low-density lipoprotein receptor (ldl-r), and reduce lipid deposition in vascular endothelial cells in a dose-dependent manner. in addition, the gene and protein expression of related scavenger receptors, including cluster of differentiation 36, sterol regulatory element binding protein 2 (SreBP), SreBP cleavage-activating protein and ldl-r, were downregulated in a dose-dependent manner. The present study noted that eGcG possesses potential as a natural product for preventing and treating metabolic hyperlipidemia syndrome, probably by reducing the blood lipid levels, alleviating vascular endothelial cell damage, maintaining normal lipid metabolism in blood vessels and ameliorating glycolipid disorders.

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Section: Discussionmentioning

confidence: 99%

Anti‑glycolipid disorder effect of epigallocatechin‑3‑gallate on high‑fat diet and STZ‑induced T2DM in mice

et al. 2020

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“…Additional boluses were added according to chest wall thickness variation. The protocol allowed for a dose variation (in the planning target volume) between 95% and 105% of that at the reference point on the central axis [5][6]. A total dose of 50-Gy radiotherapy was delivered in daily fractions of 2 Gy for five consecutive weeks.…”

Section: Routine Radiotherapy and Assessmentmentioning

confidence: 99%

“…Approximately 87-95% of irradiated patients are characterized by swelling, redness, pigmentation, ulceration, fibrosis, pain, burning and itching of the skin [2][3][4]. RSI has an impact on discomfort and the quality of life of patients [5,6], and may require interference with radiation schedules and complex surgical reconstruction, especially when combined with molecular targeted therapy [7][8][9]. However, evaluation of RSI is not straightforward.…”

Section: Introductionmentioning

confidence: 99%

Relationships between the changes of skin temperature and radiation skin injury

Zhu

Chen

et al. 2019

International Journal of Hyperthermia

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Background: Radiation skin injury (RSI) causes changes in skin temperature, but detailed information on the thermographic responses is currently lacking. We investigated thermographic patterns after radiotherapy. We hypothesized that skin temperature may be used as a diagnostic and early predictor of RSI severity. Method: All breast cancer patients received radiotherapy after unilateral postmastectomy. The contralateral supraclavicular area served as control, and the frontal thermal image of torso was taken by a thermal infrared imager weekly. We defined areas of interest on bilateral symmetrical supraclavicular area, and analyzed the difference of average and maximum skin temperature (DST average and DST max ) between them. The extent of the weekly variation in DST (DSTW) was calculated using a mathematical formula to represent a trend of skin temperature change. RSI and symptoms related to RSI were scored from baseline to 2 weeks after the end of radiotherapy. Results: Forty-one patients were enrolled in this study. In comparison to the baseline, the DST average and DST max increased significantly over time during radiotherapy (p < .05). The onset of DST increase was accompanied by the onset of radiation dermatitis, and the maximal DST also appeared at the peak of Radiation Therapy Oncology Group (RTOG) and symptom scores. Radiation dose, DST average , burning-feeling and pulling were the independent variables affecting RTOG score according to multivariate analysis (p < .001, p< .034, p< .001, p< .001). Patients with DSTW average >1.223 or DSTW max >1.114 in second week showed a late higher dermatitis score (RTOG score !2). Conclusion: This study confirmed that RSI was associated with thermographic response. Our results suggested that the follow-up observations of skin temperature during radiotherapy could provide the objective evaluation criteria and prediction methods for RSI. ARTICLE HISTORY

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“…Epigallocatechin-3-gallate (EGCG) is the main polyphenolic constituent of green tea and is widely recognized as a powerful free radical scavenger. Studies have shown EGCG to be effective in treating several disorders (Zhu et al 2016 ). Specifically, EGCG has demonstrated anti-aging, anti-angiogenic, anti-arthritic, antiviral, anti-inflammatory, and neuroprotective effects.…”

Section: Naturally Occurring Radioprotectorsmentioning

confidence: 99%

Pharmacology of natural radioprotectors

et al. 2018

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Radiotherapy is one of the most efficient ways to treat cancer. However, deleterious effects, such as acute and chronic toxicities that reduce the quality of life, may result. Naturally occurring compounds have been shown to be non-toxic over wide dose ranges and are inexpensive and effective. Additionally, pharmacological strategies have been developed that use radioprotectors to inhibit radiation-induced toxicities. Currently available radioprotectors have several limitations, including toxicity. In this review, we present the mechanisms of proven radioprotectors, ranging from free radical scavenging (the best-known mechanism of radioprotection) to molecular-based radioprotection (e.g., upregulating expression of heat shock proteins). Finally, we discuss naturally occurring compounds with radioprotective properties in the context of these mechanisms.

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Epigallocatechin-3-gallate ameliorates radiation-induced acute skin damage in breast cancer patients undergoing adjuvant radiotherapy

Cited by 45 publications

References 25 publications

Anti‑glycolipid disorder effect of epigallocatechin‑3‑gallate on high‑fat diet and STZ‑induced T2DM in mice

Anti‑glycolipid disorder effect of epigallocatechin‑3‑gallate on high‑fat diet and STZ‑induced T2DM in mice

Relationships between the changes of skin temperature and radiation skin injury

Pharmacology of natural radioprotectors

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