Epidural Clonidine Analgesia in Obstetrics

Clinical evaluation of clonidine added to lidocaine solution for subarachnoid analgesia in sheep

“…Intermediate doses of epidural CL and xylazine, in contrast to low or high ones, cause the largest decrease in blood pressure. The fact that higher doses did not result in a more marked decrease in arterial blood pressure was thought to reflect peripheral alpha‐2 effects (Eisenach et al. , 1989, 1993.…”

“…CL produces prolonged analgesia, with a long duration of action when injected into the epidural space in cattle (DeRossi et al. , 2003a,b) or sheep (Eisenach et al. , 1989), and subarachnoid administration in goats (DeRossi et al.…”

“…This mechanism is mediated by the substance P, a neurotransmitter that is important in pain perception (Pernow, 1983). However, its use is limited because of hypotension, bradycardia, sedation, and respiratory depression in humans (Eisenach et al. , 1989; Penon et al.…”

Postoperatif Ağri Tedavi̇si̇nde Epi̇dural Kloni̇di̇n İle Fentani̇li̇n Karşilaştirilmasi

“…Koyunlarda sistemik klonidin uygulaması doza bağlı olarak solunumsal ve kardiyovasküler depresyona bağlı olmaksızın periferik bir alfa 2 adrenoseptör aracılığı ile hipoksemi meydana getirir ( 17 ) . Koyunlarda bu etkinin mekanizması bilinmemesine rağmen bunun platelet agregasyonuna ve pulmoner mikroembolizme bağlı olduğu düşünülmektedir.…”

Clonidine premedication reduces maternal requirement for intravenous morphine after cesarean delivery without affecting newborn's outcome

“…[9][10][11] There are also several reports indicating that clonidine effectively reduces narcotic requirements while enhancing analgesia in parturients when administered intrathecally or by the epidural route. [12][13][14][15][16] Despite the widespread postoperative use of epidural and spinal clonidine, 2 little is known about the beneficial and/or detrimental effects of oral clonidine on either the normotensive parturient or the fetus.…”