Epididymal Lymphoma. A Case Report

Ginaldi, Lia; A, De Pasquale; M, De Martinis; Calvisi, Giuseppe; Coletti, Gino; Ventura, T; Quaglino, D

doi:10.1177/030089169307900215

Cited by 14 publications

(10 citation statements)

References 6 publications

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“…[18][19][20][21][22] In the rare reported cases of testicular plasmacytoma associated with hydrocele, the neoplasm formed a tumorous mass and the hydrocele occurred as a complication instead of being a preexisting condition. 23 Primary cardiac lymphomas are extremely rare in immunocompetent patients.…”

Section: Discussionmentioning

confidence: 99%

Diffuse large B-cell lymphoma associated with chronic inflammation as an incidental finding and new clinical scenarios

et al. 2010

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Diffuse large B-cell lymphoma that develops in the setting of long-standing chronic inflammation is typically associated with Epstein-Barr virus, and usually presents as tumor mass involving body cavities, as in pyothorax-associated lymphoma. It is listed as a distinct entity in the latest World Health Organization lymphoma classification. We report four cases that were incidentally discovered on histologic examination, one each in a splenic false cyst, a long-standing hydrocele, an atrial myxoma, and metallic-implant wear debris. Microscopic foci of atypical (neoplastic) large lymphoid cells were found within the contents of the cysts or curettage material, or within the stroma of the atrial myxoma. Despite the diverse clinical scenarios, all cases showed a homogeneous phenotype: positivity for B-lineage markers (CD20 þ , CD79a þ , PAX5 þ ), non-germinal center immunophenotype (CD10À, BCL6À/ þ , MUM-1 þ ), and positivity for Epstein-Barr virus with type III latency (LMP1 þ , EBNA2 þ ). The last feature supports the hypothesis that the lymphoma has arisen in a setting of 'local immunodeficiency' as a result of long-standing chronic inflammation in an enclosed space, a characteristic pathogenetic mechanism of diffuse large B-cell lymphoma associated with chronic inflammation. These cases therefore expand the spectrum of this entity to include new clinical scenarios for the development of this lymphoma type.

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Section: Discussionmentioning

confidence: 99%

Diffuse large B-cell lymphoma associated with chronic inflammation as an incidental finding and new clinical scenarios

et al. 2010

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“…An aspiration needle biopsy was performed in 1 patient with a suspected testicular neoplasm and malignant lymphoma was diagnosed [3]. The patient underwent radical orchiectomy.…”

Section: Discussionmentioning

confidence: 99%

Primary Lymphoma of the Epididymis

Novella¹,

Porcaro²,

Righetti³

et al. 2001

Urol Int

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Objective: To report an extremely rare clinical pathological observation of a case of primary lymphoma of the epididymis, without testicular or systemic involvement, and to update the relevant literature. Materials and Methods: A 25-year-old white male patient complaining of right scrotal pain was referred to our department. Clinical examination detected a hard painful mass at the right epididymal head. Epididymitis was diagonsed and conservative therapy with antibiotics and anti-inflammatory drugs was given. After 2 months of therapy the patient was admitted to our department because a tumor was suspected. Tumor markers were normal. Right scrotal exploration was performed through a standard inguinal incision. The epididymal head was completely replaced by a hard white mass. Fresh frozen sections indicated a malignant tumor. Right radical orchiectomy was performed. Results: High-grade primary epididymal non-Hodgkin’s lymphoma with diffuse large cells (group G according to the Working Fromulation) was diagnosed. Clinical pathological staging detected stage IE (extranodal) primary epididymal lymphoma. The patient was referred to the Hematologic Unit for combined chemotherapy, according to the VACOP-B protocol. After an 18-month follow-up the patient is well and disease free. Conclusions: When an epididymal mass does not benefit from medical treatment, scrotal exploration and fresh frozen sections of the lesion should be done. The possible bilateral involvement by primary epididymal lymphoma has to be kept in mind. Radical orchiectomy is the treatment of choice for primary lymphoma of the epididymis. Adjuvant chemotherapy is indicated in high-grade malignant lymphoma. Prognostic parameters of the disease may be the grade of malignancy and the size of the tumor.

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“…Primare Lymphome des Nebenhodens und des Samenstrangs sind sehr selten und die Literatur beschrankt sich auf Fallbeispiele. In den Nebenhoden traten primare Lymphome als DLBCL, FL und MALT-Lymphome auf [20,70,84,93,106,157,198,210,232,244]. Im Samenstrang sind die groBe Mehrheit der Lymphome als DLBCL diagnostiziert worden [52,102,102,126,182,222,244].…”

Section: Kapitel 37unclassified

Lymphoproliferative Erkrankungen des weiblichen und männlichen Genitaltrakts sowie der Mamma

2018

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Epididymal Lymphoma. A Case Report

Cited by 14 publications

References 6 publications

Diffuse large B-cell lymphoma associated with chronic inflammation as an incidental finding and new clinical scenarios

Diffuse large B-cell lymphoma associated with chronic inflammation as an incidental finding and new clinical scenarios

Primary Lymphoma of the Epididymis

Lymphoproliferative Erkrankungen des weiblichen und männlichen Genitaltrakts sowie der Mamma

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