Epidermotropic Merkel cell carcinoma: A case series with histopathologic examination

D'Agostino, Mark; Cinelli, Christina; Willard, Robert J.; Hofmann, J; Jellinek, Nathaniel J.; Robinson‐Bostom, Leslie

doi:10.1016/j.jaad.2009.06.023

Cited by 24 publications

(17 citation statements)

References 6 publications

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“…The tumor frequently infiltrates the reticular dermis and subcutis. Epidermis, papillary dermis, and the adnexa are usually spared, although sporadic cases of epidermotropic MCC have been reported . Routine hematoxylin‐eosin (H&E) staining reveals the neoplastic cells to be distinctly monomorphic.…”

Section: Diagnosismentioning

confidence: 99%

S2k guidelines for Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) – update 2018

Becker

Eigentler

Frerich

et al. 2019

J Deutsche Derma Gesell

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Summary Merkel cell carcinoma (MCC, ICD‐O M8247 / 3) is a rare malignant primary skin tumor with epithelial and neuroendocrine differentiation. The neoplastic cells share many morphological, immunohistochemical and ultrastructural characteristics with Merkel cells of the skin. The diagnosis of MCC is rarely made on clinical grounds. Histological and immunohistochemical studies are usually required to confirm the clinical suspicion. Given the frequent occurrence of occult lymph node metastasis, sentinel lymph node biopsy should be performed once distant metastasis has been ruled out by cross‐sectional imaging. Primary tumors without evidence of organ metastases are treated with complete surgical excision with appropriate surgical margins. Radiation therapy should be considered at all stages of the disease. For advanced MCC that is no longer amenable to curative treatment by surgery or radiation therapy, there is currently no established systemic therapy for which an improvement in recurrence‐free survival or overall survival has been demonstrated in a prospective randomized trial. However, immunotherapy using PD‐1/PD‐L1 blockade seems to be superior to chemotherapy. Various factors warrant that further diagnostic and therapeutic interventions be determined by an interdisciplinary tumor board. These factors include the tumor's aggressiveness, the frequent indication for sentinel lymph node biopsy along with the frequent occurrence in the head and neck region, the potential indication for adjuvant radiation therapy as well as the complexity of the required diagnostic workup.

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Section: Diagnosismentioning

confidence: 99%

S2k guidelines for Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) – update 2018

Becker

Eigentler

Frerich

et al. 2019

J Deutsche Derma Gesell

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“…However, unlike BCC, MCC may have an intraepidermal component. [108][109][110][111] Both MCC and BCC may have focal or extensive squamous differentiation. 105 Peripheral palisading may be identified in a few MCC tumors but is typically focal.…”

Section: Sebaceous Carcinomamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. Objective.— To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. Data Sources.— Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. Conclusions.— In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

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“…Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer most commonly occurring among the elderly and among immunosuppressed persons, including AIDS patients ( 1 – 3 ). By using digital transcriptome subtraction, Feng et al recently discovered Merkel cell polyomavirus (MCV) clonally integrated in the tumor cell genome of ≈80% of MCC ( 4 ).…”

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confidence: 99%