“…EH is an essential histologic finding in three hered itary skin diseases: bullous congenital ichthyosiform erythroderma, systematized nevus verrucosus and her editary palmoplantar keratoderma of Vomer (7,8], Moreover EH can be seen in a number of other skin le sions as an incidental finding in combination with the distinct histopathologic features of those lesions, i.e., pi lar cyst, seborrheic keratosis, cutaneous hom, basal and squamous cell carcinoma, actinic keratosis, leukokeratosis, intradermal nevus, malignant melanoma, granu loma annulare and lichen amyloidosis [6,9,10]. This strange histologic finding has also been made in the ap parently normal skin and oral mucosa adjacent to be nign and malignant epidermal tumors [6,11], The ul trastructural pattern of EA is very close to that seen in bullous congenital ichthyosiform erythroderma and in systematized nevus verrucosus [2,3]. Both diseases show intracellular edema, abnormal aggregations of tonofilaments around the nucleus and disturbed connections be tween tonofilaments and desmosomes.…”