Epidermolytic hyperkeratosis as an incidental finding in normal oral mucosa

Vulvar Localisation of Epidermolytic Acanthoma

“…EH is an essential histologic finding in three hered itary skin diseases: bullous congenital ichthyosiform erythroderma, systematized nevus verrucosus and her editary palmoplantar keratoderma of Vomer (7,8], Moreover EH can be seen in a number of other skin le sions as an incidental finding in combination with the distinct histopathologic features of those lesions, i.e., pi lar cyst, seborrheic keratosis, cutaneous hom, basal and squamous cell carcinoma, actinic keratosis, leukokeratosis, intradermal nevus, malignant melanoma, granu loma annulare and lichen amyloidosis [6,9,10]. This strange histologic finding has also been made in the ap parently normal skin and oral mucosa adjacent to be nign and malignant epidermal tumors [6,11], The ul trastructural pattern of EA is very close to that seen in bullous congenital ichthyosiform erythroderma and in systematized nevus verrucosus [2,3]. Both diseases show intracellular edema, abnormal aggregations of tonofilaments around the nucleus and disturbed connections be tween tonofilaments and desmosomes.…”

Incidental Cutaneous Reaction Patterns: Epidermolytic Hyperkeratosis, Acantholytic Dyskeratosis, and Hailey-Hailey-Like Acantholysis: A Potential Marker of Premalignant Skin Change

“…The average patient age was 68 years (range 54–85). Six cases were associated with excisions of epidermal malignancies: basal cell carcinoma [16], squamous cell carcinoma [9], and melanoma in situ [7]. Three cases were associated with biopsies of dysplastic/Clark's nevi (out of a total of 82 dysplastic nevi diagnosed during this period) (Figure 1).…”

Epidermolytic Hyperkeratosis Associated with a Dilated Pore

“…In addition, a focus of EH is often found in normal skin adjacent to or over other conditions, such as squamous cell carcinoma, lichenoid amyloidosis, granuloma annulare, senile sebaceous hyperplasia, intradermal nevus, actinic keratosis, and hypertrophic scar (1,8,9). A recent observation showed that the changes of EH were also incidentally found in normal mucosa (10).…”