Epidermolysis bullosa in oral health: clinical manifestations and salivary alterations

Azevedo, Brenda Lamônica Rodrigues de; Roni, Gabriel Marim; Dettogni, Raquel Spinassé; Torrelio, Rosalie Matuk Fuentes; Leal, Lucas Fernandes; Gama-de-Souza, Letícia Nogueira da

doi:10.1007/s00784-023-04917-3

Cited by 1 publication

(4 citation statements)

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“…The absence of collagen VII during embryonic development may impair glandular formation. Individuals with EB may have changes in the salivary glands, mammary glands, and skin sebaceous glands [27]. No statistically significant difference was found in terms of hand and nail dystrophy when compared according to the gender variable (p > 0.05).…”

Section: Discussionmentioning

confidence: 82%

“…In de Azevedo et al’s study of clinical signs of EB and salivary changes, the RDEB group showed all the features of ankyloglossia in relation to the oral mucosa, and the JEB group showed deformity in the skin and nails. In saliva analysis, the authors observed no difference between the control and EB groups [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The salivary flow rate, pH and buffering capacity were not found to be different in individuals with EB compared to normal individuals [ 27 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Clinical and Oral Findings in Patients with Epidermolysis bullosa

Yavuz,

An,

Yazmaci

et al. 2023

Medicina

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Introduction: Epidermolysis bullosa (EB) is a genetically inherited disease characterized by recurrent bullae and erosions on the skin with numerous signs of dental caries and poor oral hygiene. The aim of this study was to investigate the general clinical and oral findings of patients with EB. Materials and Methods: In this prospective study, the clinical and oral findings and family history of 26 cases with EB were evaluated. The type of EB, gender, age, parental consanguinity, dental caries, oral findings, distribution of lesions and presence of associated anomalies, clinical and oral findings correlated with gender were recorded. Results: All 26 patients with EB had a history of consanguinity and siblings with EB to varying degrees. In our study, malnutrition, anemia and growth retardation, gastrointestinal system complications, hair thinning, hand and nail deformity, ocular problems and renal disease (in one case) were observed with variable frequencies. When the intraoral findings of the patients were investigated, extensive dental caries in all EB types, enamel hypoplasia in junctional EB (JEB) and the presence of tooth-root to be extracted in dystrophic EB (DEB), intraoral bullae and lesions, ankyloglossia, vestibular sulcus insufficiency, microstomia and maxillary atrophy were observed. Three cases had restorative treatment and one case had prosthetic rehabilitation. Conclusions: Oral involvement can be seen with varying frequencies depending on the type of EB and the severity of the disease. It may result from delayed oral and dental rehabilitation due to physical disabilities, limitations and more pressing medical problems. Microstomy, pain from mucosal lesions, and restricted access to the mouth can be caused by poor oral hygiene. Oral complications and caloric needs of individuals with EB should be determined, and individual prophylaxis should be applied to prevent caries formation and protect teeth.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The salivary flow rate, pH and buffering capacity were not found to be different in individuals with EB compared to normal individuals [ 27 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

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