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Cited by 24 publications
(9 citation statements)
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“…This finding is similar to that of epidermolysis bullosa hereditaria and could explain skin fragility [111,112]. When performed from lesional skin, the cleavage plane can be demonstrated.…”
Section: Immunoelectron Microscopysupporting
confidence: 80%
“…This finding is similar to that of epidermolysis bullosa hereditaria and could explain skin fragility [111,112]. When performed from lesional skin, the cleavage plane can be demonstrated.…”
Section: Immunoelectron Microscopysupporting
confidence: 80%
“…Direct immunofluorescence of perilesional skin biopsies from EBA patients reveals IgG deposits at the dermal-epidermal junction [7][8][9]. EBA antibodies bind to type VII collagen within anchoring fibrils [2].…”
mentioning
confidence: 99%
“…In 1971, Roenigk, Ryan & Berfeld (1971) suggested four criteria for the diagnosis of EBA: (i) clinical lesions of trauma-induced bulla occurring over the joints of the hands, feet, elbows and knees, atrophic scars, milia and nail dystrophy; (2) post infancy onset of the disease; (3) no family history of EBA; and (4) exclusion of other bullous diseases. Based on the subsequent immunopathological studies of Kushniruk (1973) and Gibbs & Minus (1975) and more recently, immunoelectronmicroscopic studies of Nieboer et al (1980), Roenigk & Pearson (1981) have added three diagnostic criteria to the above: (i) the finding of IgG at the basement membrane zone (BMZ) by direct immunofluorescence microscopy (IF); (2) demonstration of blister formation beneath the basal lamina with a zone of amorphous material beneath remaining on the epidermal side of the blister by electronmicroscopy; and (3) deposition of IgG in the amorphous zone beneath the basal lamina, demonstrable by immunoelectronmicroscopy.…”
Section: Discussionmentioning
confidence: 99%