Epidermolysis bullosa acquisita: Diagnosis by electron microscopy

Epidermolysis Bullosa Acquisita Diagnosed by Immunoelectron Microscopy

“…Several attempts have been made to establish the criteria for the diagnosis of EBA, and, in 1971, Roenigk et aI. (3) suggested the following four criteria; 1) clinical lesions of traumainduced bullae occurring over the joints of the hands, feet, elbows, and knees; atrophic scars; milia; and nail dystrophy, 2) adult onset of the disease, 3) no family history of EB, and 4) exclusion of other bullous disease, Immunopa-thologicaIly, Kushniruk (4) and others (5,6) demonstrated ,11. vivo bound IgG and sometimes C3 deposits in a linear fashion along the basement membrane zone of the skin of patients with this disease. These findings are similar to those seen in bullous pemphigoid.…”