Epidermoid carcinoma of the palate

Evans, James F.; Shah, Jatin P.

doi:10.1016/0002-9610(81)90373-1

Cited by 41 publications

(12 citation statements)

References 12 publications

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“…Our rate of survival at 5 years was 44.5% and is similar to those reported by other studies (21% to 76%) [18,19] . This poor prognosis could reflect higher prevalence of neck node involvement at diagnosis or higher prevalence of poor prognotic factors like p16-negative status [1] .…”

Section: Discussionsupporting

confidence: 81%

“…Neck recurrence was predicted by the presence of fixed or contralateral node metastases, but not by the presence of nodal metastasis itself. Size of the primary tumor and histological grade was significantly associated with survival, and clinical stage was the most important prognostic indicator [30] . Recent retrospective series with 26 to 146 upper alveolar ridge and hard palate cases reported a neck lymph node involvement between 11% and 36.6%, and regional recurrence in N0 neck from 14% to 27% [1,[5][6][7][8] .…”

Section: Discussionmentioning

confidence: 99%

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Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

Salas¹,

Sanchez²,

Postigo³

et al. 2018

JCMT

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Aim: Upper alveolar ridge and hard palate squamous cancer is an infrequent malignancy. We evaluated factors associated with neck involvement and with p16-staining. Methods:Head and neck squamous-cell carcinoma (SCC) patients who went to Head and Neck Department between 1997 and 2011 were screened, and 73 resected upper alveolar ridge and 5 hard palate SCC were selected. Tumors with available tissue were stained with p16 immunohistochemistry.Results: Median age was 64.4 years, 55.1% were female, and 73.1% were in clinical stage IV. Neck dissections were performed in 24 and pathologically confirmed node metastases were found in 19 (24.3%). Cervical recurrence was found in 18 patients (23.1%) and was associated with histological grade (P = 0.037). Three (7.3%) of 41 lesions were positive for p16 and tended to be younger (P = 0.067). Lymphovascular invasion was associated with shorter disease-free survival (DFS) (P = 0.026) and overall survival (OS) (P = 0.021). Larger cT (P = 0.019), perineural invasion (P = 0.039) and neck dissection (P = 0.010) were associated with shorter OS. Neck node involvement tended to have shorter DFS (31% vs. 48.7%, P = 0.278) and OS (25.1% vs. 48.5%, P = 0.340), and neck recurrence tended to have shorter OS (9.3% vs. 52.3%, P = 0.064). Conclusion:Neck involvement and recurrence are frequent in this location. P16-positive cases were present in 7.3% and tended to be associated with younger age.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

Salas¹,

Sanchez²,

Postigo³

et al. 2018

JCMT

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“…In contrast to the abundance of literature investigating the prognosis of the various stages and treatment options of SCC primaries of other oral cavity subsites, recent studies on maxillary alveolus and hard palate cancers have predominantly been limited to reports from institutional experiences and other small patient number series 1, 4–6. Larger case series, including reports on as many as 62 to 123 patients with SCC of the hard palate, were conducted on patients treated in the 1920s to the 1970s prior to the creation of standardized staging systems or routine use of modern imaging and therapeutic modalities, or grouped with other nonoral cavity cancer subsites for statistical analysis 11, 12. Since the institution of standardized staging criteria to classify disease severity and to guide treatment strategy, some authors have more recently suggested that the UICC/AJCC staging system may inadequately predict the prognosis of patients with SCC of the maxillary alveolus and hard palate, and have therefore proposed alternative staging systems for these specific subsites 2, 3…”

Section: Discussionmentioning

confidence: 99%

Survival impact of nodal disease in hard palate and maxillary alveolus cancer

Lin

Bhattacharyya

2009

The Laryngoscope

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“…8,9 In contrast, for maxillary alveolus and hard palate tumors, it has traditionally been believed that the risk of nodal metastases is not high enough to warrant ELND. [10][11][12][13][14] Therefore, in the majority of cases, in the absence of clinical evidence of cervical nodal metastases, neck dissection is generally not recommended, independent of the size or depth. [15][16][17][18] Several single-institution analyses have recently reported higher than expected rates of nodal failure among patients undergoing surgery, without neck dissection, for SCCs of the maxillary alveolus and hard palate.…”

Section: Introductionmentioning

confidence: 99%

Impact of elective neck dissection on the outcome of oral squamous cell carcinomas arising in the maxillary alveolus and hard palate

et al. 2015

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Background Whether elective lymph neck dissection (ELND) is associated with improved survival in oral squamous cell carcinomas (SCC) of the maxillary alveolus/hard palate is not known. Methods One hundred ninety-nine patients presenting de novo and receiving treatment for clinically node negative SCC of the maxillary alveolus/hard palate at 2 cancer centers between 1985 and 2011 were analyzed. Results Forty-two patients (21%) received ELND. Occult nodal metastases were present in 29% of the dissected necks. The ELND group had more T3 to T4 status tumors (62% vs 34%; p < .001) and positive-margin resections (59% vs 38%; p = .019). Patients undergoing ELND experienced lower rates of neck recurrence (6% vs 21%; p = .031), superior 5-year recurrence-free survival (68% vs 45%; p = .026), and overall survival (86% vs 62%; p = .043). ELND was associated with a 2-fold decrease in risk of recurrence in multivariable analysis. Conclusion ELND was associated with lower rates of recurrence and improved survival in SCC of the maxillary alveolus/hard palate.

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Epidermoid carcinoma of the palate

Cited by 41 publications

References 12 publications

Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

Survival impact of nodal disease in hard palate and maxillary alveolus cancer

Impact of elective neck dissection on the outcome of oral squamous cell carcinomas arising in the maxillary alveolus and hard palate

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