Epidermoid carcinoma of the anal canal: treatment by combined radiation and chemotherapy

Grabenbauer, Gerhard G.; Schneider, Ines; Gall, F. P.; Sauer, Rolf

doi:10.1016/0167-8140(93)90045-a

Cited by 24 publications

(7 citation statements)

References 15 publications

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“…Placing the results of this study in the context of cancer treatment, the magnitude of these results ( Figure 2 ) is less than that of chemotherapy clinical trials but still clinically meaningful. Here, we observe a survival differential of 2% for patients at low to moderate risk when comparing no co-presence vs only co-presence with surviving patients, whereas effective chemotherapy clinical trials report survival differences of around 8% ( Grabenbauer et al, 1993 ; Rapp et al, 1988 ). In effect, chemotherapy patient survival may be modified by one-quarter the quantity of the effect of the choice of chemotherapy.…”

Section: Discussionmentioning

confidence: 66%

Social influence on 5-year survival in a longitudinal chemotherapy ward co-presence network

Lienert

Marcum²,

Finney³

et al. 2017

Net Sci

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Chemotherapy is often administered in openly designed hospital wards, where the possibility of patient–patient social influence on health exists. Previous research found that social relationships influence cancer patient’s health; however, we have yet to understand social influence among patients receiving chemotherapy in the hospital. We investigate the influence of co-presence in a chemotherapy ward. We use data on 4,691 cancer patients undergoing chemotherapy in Oxfordshire, United Kingdom who average 59.8 years of age, and 44% are Male. We construct a network of patients where edges exist when patients are co-present in the ward, weighted by both patients’ time in the ward. Social influence is based on total weighted co-presence with focal patients’ immediate neighbors, considering neighbors’ 5-year mortality. Generalized estimating equations evaluated the effect of neighbors’ 5-year mortality on focal patient’s 5-year mortality. Each 1,000-unit increase in weighted co-presence with a patient who dies within 5 years increases a patient’s mortality odds by 42% (β = 0.357, CI:0.204,0.510). Each 1,000-unit increase in co-presence with a patient surviving 5 years reduces a patient’s odds of dying by 30% (β = −0.344, CI:−0.538,0.149). Our results suggest that social influence occurs in chemotherapy wards, and thus may need to be considered in chemotherapy delivery.

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Section: Discussionmentioning

confidence: 66%

Social influence on 5-year survival in a longitudinal chemotherapy ward co-presence network

Lienert

Marcum²,

Finney³

et al. 2017

Net Sci

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“…The incidence of late radiation proctopathy or proctitis ranged from 0 to 40% [92][93][94][95][96][97]. In CTCAE criteria, the definition of proctitis is unclear and likely to be overlapped with other late toxicities, because Grade 1 is 'rectal discomfort', Grade 2 is 'passing blood or mucus', and Grade 3 is 'stool incontinence'.…”

Section: Radiation Proctopathy/proctitis/mucositismentioning

confidence: 99%

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review

et al. 2018

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Introduction: There is a paucity of data on incidence and mechanisms of long-term gastrointestinal consequences after chemoradiotherapy for anal cancer. Most of the adverse effects reported were based on traditional external beam radiotherapy whilst only short-term follow-ups have been available for intensity-modulated radiotherapy, and there is lack of knowledge about consequences of doseescalation radiotherapy. Method: A systematic literature review. Results: Two thousand nine hundred and eighty-five titles (excluding duplicates) were identified through the search; 130 articles were included in this review. The overall incidence of late gastrointestinal toxicity was reported to be 7-64.5%, with Grade 3 and above (classified as severe) up to 33.3%. The most commonly reported late toxicities were fecal incontinence (up to 44%), diarrhea (up to 26.7%), and ulceration (up to 22.6%). Diarrhea, fecal incontinence and buttock pain were associated with lower scores in radiotherapy specific quality of life scales (QLQ-CR29, QLQ-C30, and QLQ-CR38) compared to healthy controls. Intensity-modulated radiation therapy appears to reduce late toxicity. Conclusion: Late gastrointestinal toxicities are common with severe toxicity seen in one-third of the patients. These symptoms significantly impact on patients' quality of life. Prospective studies with control groups are needed to elucidate long-term toxicity.

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“…The introduction of simultaneous radiochemotherapy by Nigro et al 8 with refinements in fractionation schedules and treatment techniques and the combination with 5-fluorouracil (5-FU) and mitomycin C provided further improvement of tumor response and colostomy-free survival rates. [8][9][10][11][12] As of today this approach has been confirmed by two randomized prospective trials comparing radiation alone to combined radiochemotherapy, both for primary advanced disease 13 and for tumors of all stages. 14,15 However, significant acute and especially late morbidity has been associated with radiation treatment as delivered in these trials.…”

mentioning

confidence: 98%

Tumor Site Predicts Outcome After Radiochemotherapy in Squamous-Cell Carcinoma of the Anal Region: Long-Term Results of 101 Patients

Grabenbauer

Keßler

Matzel

et al. 2005

Diseases of the Colon &Amp; Rectum

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Epidermoid carcinoma of the anal canal: treatment by combined radiation and chemotherapy

Cited by 24 publications

References 15 publications

Social influence on 5-year survival in a longitudinal chemotherapy ward co-presence network

Social influence on 5-year survival in a longitudinal chemotherapy ward co-presence network

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review

Tumor Site Predicts Outcome After Radiochemotherapy in Squamous-Cell Carcinoma of the Anal Region: Long-Term Results of 101 Patients

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