Epidermoid carcinoma arising in extensive chromoblastomycosis

Caplan, R. M.

doi:10.1001/archderm.97.1.38

Cited by 11 publications

(8 citation statements)

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“…It rather affects quality of life due to the multiple infections that may occur. An exceptional case included in our series developed a epidermoid carcinoma, probably due to the chronicity of the disease; this had already been reported and its cause may be compared with that seen in patients with a history of extensive burns who develop this type of neoplasia later [5, 16]. It is important to note that in two cases of foot chromoblastomycosis the initial lesion spread and involved the toe nail (Fig.…”

Section: Discussionmentioning

confidence: 66%

Chromoblastomycosis: clinical and mycologic experience of 51 cases

Bonifáz

Carrasco‐Gerard

Saúl

2001

Mycoses

189

166

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This is a study of 51 cases of chromoblastomycosis detected in a 17-year period, all of which were clinically and mycologically proven by direct examinations, cultures and biopsies. The therapeutic results of the various treatments used are reported. Most cases were males (36 of 51; 70%), the mean age was 35 years and farmers predominated (74%); the most frequent lesions were in the lower limbs (54%). Major clinical presentations were nodular (41%) and verrucous (26%). The principal aetiologic agent isolated was Fonsecaea pedrosoi (90%). Overall results of the various treatments were as follows: 31% were cured, 57% improved and 12% failed. The best results were obtained with cryosurgery for small lesions, with itraconazole for large ones, and in some cases the combination of both treatments.

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Section: Discussionmentioning

confidence: 66%

Chromoblastomycosis: clinical and mycologic experience of 51 cases

Bonifáz

Carrasco‐Gerard

Saúl

2001

Mycoses

189

166

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“…When observed under the microscope, histological sections are shown to be composed of an external layer of fibrous tissue and an internal layer of thick granulomatous inflammatory tissue containing polymorphonuclear leukocytes, histiocytes and multinucleated giant cells (Silva & Ekizlerian, 1985;Brandt & Warnock, 2003). In some cases, especially the long standing ones, the presence of chronic inflammatory reaction and fibrous cicatricial tissue offer a favourable condition for the development of malignant skin neoplasm (Caplan, 1968;Foster & Harris, 1987;Dos Santos Gon & Minelli, 2006). Systemic invasion following chromoblastomycosis is very rare.…”

Section: Pathophysiology and Diagnosis Of Chromoblastomycosismentioning

confidence: 99%

Biology and pathogenesis ofFonsecaea pedrosoi, the major etiologic agent of chromoblastomycosis

et al. 2007

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Fonsecaea pedrosoi is the principal etiologic agent of chromoblastomycosis, a fungal disease whose pathogenic events are poorly understood. Treatment of the disease presents poor effectiveness and serious side effects. The disease is epidemiologically important in several regions, which has stimulated studies focused on the biology and pathogenic potential of its major causative agent. In this review, we summarize the current knowledge on the biological aspects of F. pedrosoi, including cell differentiation and pathogenic mechanisms during the interaction of fungi with different hosts' elements.

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“…Although malignant transformation of chronic CMB lesions has previously been demonstrated the rate of neoplastic transformation is low. 9 , 10 In India, only 1 out 70 patients with chromoblastomycosis developed squamous cell carcinoma, 11 similarly in Mexico from 51 patients analyzed, carcinoma was identified in only 1 patient. 12 …”

Section: Discussionmentioning

confidence: 98%

Chromoblastomycosis evolving to sarcomatoid squamous cell carcinoma: A case report

et al. 2021

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Chromoblastomycosis (CMB) is a cutaneous fungal infection caused by dematiaceous fungi. According to the World Health Organization CMB has been elected as a tropical disease, and it is prevalent in tropical and subtropical regions. The lower extremities are the most affected areas, and the lesions progress with erythema, papules, nodules, verrucose plates and/or ulcerations. So far, few works have demonstrated neoplastic transformation in chronic CMB lesions, and it may be a consequence of prolonged inflammatory response. In the present case report, we described a neoplastic transformation from CMB lesion of a 55- year-old man, presenting lesions only in the left leg for 35 years. After treatment, a verrucous white plate with thick and irregular borders emerged in the ankle, which was identified as a sarcomatoid squamous cell carcinoma. The present case report highlights the importance of an early diagnosis and treatment.

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Epidermoid carcinoma arising in extensive chromoblastomycosis

Cited by 11 publications

References 0 publications

Chromoblastomycosis: clinical and mycologic experience of 51 cases

Chromoblastomycosis: clinical and mycologic experience of 51 cases

Biology and pathogenesis ofFonsecaea pedrosoi, the major etiologic agent of chromoblastomycosis

Chromoblastomycosis evolving to sarcomatoid squamous cell carcinoma: A case report

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