Epidermodisplasia verruciforme adquirida en una paciente transplantada renal

Gómez-Bernal, S.; Rodríguez-Pazos, L.; Pereiro-Ferreirós, M.M.; Toribio, Jaime

doi:10.1016/j.ad.2010.04.016

Cited by 11 publications

(2 citation statements)

References 10 publications

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“…10 However, most cases in our literature search of patients with AEV following renal transplant did not report resolution of lesions. 3,8,11,12 Several possible treatment modalities have been reported including acitretin, imiquimod, and topical calcipotriol. 5 Multiple case reports or reviews have also suggested therapies such as squaric acid dibutylester, ingenol mebutae, photodynamic therapy, interferon therapy, and immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant

Henning

Weaver

Reedy³

2020

The American Journal of Dermatopathology

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Epidermodysplasia verruciformis (EV) is a rare dermatologic condition that is clinically characterized by flat, cutaneous, verrucous papules, pityriasis versicolor-like lesions, and similar lichenoid papules. There are 2 forms of EV: a classic inherited genodermatosis and a secondary acquired form. EV predisposes individuals to infections with certain types of human papillomavirus virus and subsequently increases the risk of cutaneous squamous cell carcinoma. The acquired form occurs in immunosuppressed patients, particularly in patients infected with HIV; however, it has also been described in patients who have undergone stem cell and solid organ transplantation. We report an additional case of renal transplantation and immunosuppressive therapy-associated acquired EV (AEV) in a 78-year-old man with multiple flesh-colored to violaceous, flattopped papules distributed on the face and trunk clinically mimicking lichen planus. Biopsy was typical for that of EV, demonstrating enlarged keratinocytes with a blue-gray cytoplasm, a thickened granular layer, acanthosis, and hyperkeratosis. Herein, we discuss an unusual presentation of an AEV-mimicking lichen planus with review of the literature.

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Section: Discussionmentioning

confidence: 99%

Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant

Henning

Weaver

Reedy³

2020

The American Journal of Dermatopathology

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“…3-6 Reports of acquired EV in kidney transplanted patients are rare, with few cases described in the worldwide literature to date. 7-9 …”

Section: Introductionmentioning

confidence: 99%

Acquired epidermodysplasia verruciformis in a renal transplant recipient - Case report

Mendes

Bittencourt

Moure

et al. 2014

An. Bras. Dermatol.

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A 24-year-old male patient, who underwent kidney transplant six years ago due to Lupus nephritis, for the last two years presented asymptomatic erythematous scaly plaques on the abdomen and areas exposed to light. Post-transplantation immunosuppressive medications included prednisone, mycophenolate sodium and sirolimus. The histopathologic features were typical for epidermodysplasia verruciformis. Epidermodysplasia verruciformis is a rare autosomal recessive genodermatosis with increased susceptibility to specific strains of cutaneous human papilloma virus. The term ''acquired epidermodysplasia verruciformis'' was recently introduced to the literature and describes epidermodysplasia verruciformis occurring in patients with impaired cell-mediated immunity. We report an additional case associated to immunosuppression after kidney transplantation.

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Acquired epidermodysplasia verruciformis in renal‐transplant recipients

Gara

Jones

Litaiem

et al. 2020

Clinical Case Reports

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Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis, associated with a high susceptibility to infection with particular genotypes of human papillomaviruses (HPV) that are innocuous for the general population. Acquired forms of EV have been recently distinguished as an entity occurring in immunocompromised patients such as HIV-infected subjects or organ-transplant recipients. 1 Clinical presentation can be variable, often similar to the inherited forms. Studies reporting acquired EV in renal-transplant recipients are scarce. Herein, we report a case of an acquired EV in a renal-transplant recipient and review the available literature data. 2 | CASE REPORT A 30-year-old male patient with a four-year history of kidney transplantation for indeterminate nephropathy with end-stage renal disease and who was treated at our department for a drug reaction to amphotericin B he had received for a visceral leishmaniasis presented for a recurrence of the cutaneous eruption, evolving for the last 6 days. He was under post-transplant maintenance immunosuppressive therapy including prednisone, mycophenolate mofetil, and tacrolimus. Physical examination revealed multiple erythematous and confluent macules and papules of the torso and abdomen (Figure 1A-C). No verrucous lesions or tinea versicolor-like lesions were found. A skin biopsy of the macules was performed. Histological examination showed, in the upper epidermis, foci of keratinocytes of increased size, with enlarged nuclei and a bubbly, bluish, abundant cytoplasm, containing variably sized keratohyaline granules (Figure 2). There were no signs of drug reaction. Histological features were consistent with the diagnosis of acquired EV. There was no history of affected relatives. A regular sunscreen application and close follow-up were proposed. 3 | DISCUSSION Epidermodysplasia verruciformis is a rare inherited genodermatosis characterized by an increased susceptibility to

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Epidermodisplasia verruciforme adquirida en una paciente transplantada renal

Cited by 11 publications

References 10 publications

Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant

Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant

Acquired epidermodysplasia verruciformis in a renal transplant recipient - Case report

Acquired epidermodysplasia verruciformis in renal‐transplant recipients

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