Epidermal stem cells

Webb, Angela; Kaur, Pritinder

doi:10.2741/1861

Cited by 14 publications

(15 citation statements)

References 76 publications

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“…There are several similarities between the keratinized epithelium of the TM and the epidermis of regular skin. In the skin, stem cells are found in close proximity to hair follicles, in interfollicular locations and in sebaceous glands [Fuchs, 2007;Potten, 1974;Webb and Kaur, 2006]. If there are stem cells in the TM that resemble any of the aforementioned stem cells of the epidermis, they are likely to be the interfollicular stem cells, since the TM lacks hair follicles and glands.…”

Section: Discussionmentioning

confidence: 99%

“…In the epidermis, stem cells are found in 3 different locations: in close proximity to the hair follicle (follicular stem cells), in the deep rete of the dermal-epidermal junc-tions (interfollicular stem cells) and in the sebaceous glands [Fuchs, 2007;Potten, 1974;Webb and Kaur, 2006]. Since the TM lacks hair follicles and glands, epithelial stem cells of the TM would more likely share features with the interfollicular stem cells than with the other types.…”

Section: Introductionmentioning

confidence: 99%

“…There are currently no stem cell markers that unequivocally identify interfollicular epidermal stem cells [Alonso and Fuchs, 2003;Terunuma et al, 2007]. The best marker to date, with the highest sensitivity and specificity, is ␣ 6 -integrin [Webb and Kaur, 2006]. Additional antigens that have been used are ␤ 1 -integrin and cytokeratins 15 and 19 [Kaur, 2006;Webb and Kaur, 2006].…”

Section: Introductionmentioning

confidence: 99%

“…The best marker to date, with the highest sensitivity and specificity, is ␣ 6 -integrin [Webb and Kaur, 2006]. Additional antigens that have been used are ␤ 1 -integrin and cytokeratins 15 and 19 [Kaur, 2006;Webb and Kaur, 2006].…”

Section: Introductionmentioning

confidence: 99%

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Localization of Progenitor/Stem Cells in the Human Tympanic Membrane

2010

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Background: The outer epithelium of the tympanic membrane (TM) initiates the closure of a perforation. Embryonic stem cells have been used in attempts to enhance the healing capacity of induced perforations in experimental animals. More knowledge about epithelial cell proliferation and cell migration is needed for a better understanding of the TM healing process. This includes the identification of regenerative zones within the outer epithelial layer of the TM where progenitor cells may be present. Methods: Normal human TMs from translabyrinthine surgery were investigated using immunohistochemistry and immunofluorescence to detect the progenitor/stem cell markers α₆-integrin, β₁-integrin and cytokeratin 19 (CK19). Results: α₆-Integrin was detected in the basal layer of the keratinizing epithelium in the umbo, in the annular region and along the malleus but not in the intermediate portion of the pars tensa. β₁-Integrin and CK19 were found in the same locations not only in the basal layer but also in the suprabasal layers of the keratinizing epithelium. Conclusions: Possible progenitor cells are found in the umbo, the annular region and along the malleus. Further studies are needed to identify the source of these cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Localization of Progenitor/Stem Cells in the Human Tympanic Membrane

2010

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“…The holoclones give rise to the largest colonies in clonal growth assays and are rich in markers of the epidermal basal layer, including β1-integrin [69]. Subsequent studies reveal that these cells are rich in α6-integrin and express low levels of CD71 (transferrin receptor) [128,129]. α6-integrin bri /CD71 dim cells display many stem cell features, including quiescence and long-term growth capacity (Table 1) [74,128,129].…”

Section: Introduction — the Epidermismentioning

confidence: 99%

Biochemistry of epidermal stem cells

Eckert

Adhikary

Balasubramanian

et al. 2013

Biochimica et Biophysica Acta (BBA) - General Subjects

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Background The epidermis is an important protective barrier that is essential for maintenance of life. Maintaining this barrier requires continuous cell proliferation and differentiation. Moreover, these processes must be balanced to produce a normal epidermis. The stem cells of the epidermis reside in specific locations in the basal epidermis, hair follicle and sebaceous glands and these cells are responsible for replenishment of this tissue. Scope of review A great deal of effort has gone into identifying protein epitopes that mark stem cells, in identifying stem cell niche locations, and in understanding how stem cell populations are related. We discuss these studies as they apply to understanding normal epidermal homeostasis and skin cancer. Major conclusions An assortment of stem cell markers have been identified that permit assignment of stem cells to specific regions of the epidermis, and progress has been made in understanding the role of these cells in normal epidermal homeostasis and in conditions of tissue stress. A key finding is the multiple stem cell populations exist in epidermis that give rise to different structures, and that multiple stem cell types may contribute to repair in damaged epidermis. General significance Understanding epidermal stem cell biology is likely to lead to important therapies for treating skin diseases and cancer, and will also contribute to our understanding of stem cells in other systems. This article is part of a Special Issue entitled Biochemistry of Stem Cells.

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The Life Cycle of Human Papillomaviruses

Moody

Laimins²

2008

DNA Tumor Viruses

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Epidermal stem cells

Cited by 14 publications

References 76 publications

Localization of Progenitor/Stem Cells in the Human Tympanic Membrane

Localization of Progenitor/Stem Cells in the Human Tympanic Membrane

Biochemistry of epidermal stem cells

The Life Cycle of Human Papillomaviruses

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