Epidermal Overexpression of Stratum Corneum Chymotryptic Enzyme in Mice: A Model for Chronic Itchy Dermatitis

Bäckman, Assar; Ny, Annelii; Edlund, Michael; Ekholm, Elisabeth; Hammarström, Barbro Ekstrand; Törnell, Jan; Wallbrandt, Pia; Egelrud, Torbjörn; Hansson, Lennart; Wennbo, Håkan

doi:10.1046/j.0022-202x.2001.01684.x

Cited by 153 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The importance of KLKs in skin homeostasis is clearly seen in Netherton syndrome, a severe skin disease in which the KLK inhibitor LEKTI is absent, as discussed earlier (see paragraph 2.2.1). Transgenic KLK-5 and -7 mice reproduce the major cutaneous and systemic hallmarks of the Netherton syndrome, including epidermal thickness, hyperkeratosis, dermal inflammation, and severe pruritus [87, 88]. Also KLK8 has been described as kallikrein expressed by keratinocytes, with potential function in skin barrier proteolytic function [89].…”

Section: Physiological Function Of Klksmentioning

confidence: 99%

Kallikreins – The melting pot of activity and function

et al. 2016

View full text Add to dashboard Cite

The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with diverse expression patterns and physiological roles. Because of the broad spectrum of processes that are modulated by kallikreins, these proteases are the subject of extensive investigations. This review brings together basic information about the biochemical properties affecting enzymatic activity, with highlights on post-translational modifications, especially glycosylation. Additionally, we present the current state of knowledge regarding the physiological functions of KLKs in major human organs and outline recent discoveries pertinent to the involvement of kallikreins in cell signaling and in viral infections. Despite the current depth of knowledge of these enzymes, many questions regarding the roles of kallikreins in health and disease remain unanswered.

show abstract

Section: Physiological Function Of Klksmentioning

confidence: 99%

Kallikreins – The melting pot of activity and function

et al. 2016

View full text Add to dashboard Cite

show abstract

“…An elevated expression of hK7 (human tissue kallikrein 7) or SCCE in the epidermis leads to increased proteolytic activity, pathological desquamation, and inflammation in many skin diseases such as Netherton syndrome, psoriasis, and atopic dermatitis. [242526]…”

Section: Pathogenesismentioning

confidence: 99%

Hand eczema

et al. 2014

View full text Add to dashboard Cite

Hand eczema is often a chronic, multifactorial disease. It is usually related to occupational or routine household activities. Exact etiology of the disease is difficult to determine. It may become severe enough and disabling to many of patients in course of time. An estimated 2-10% of population is likely to develop hand eczema at some point of time during life. It appears to be the most common occupational skin disease, comprising 9-35% of all occupational diseases and up to 80% or more of all occupational contact dermatitis. So, it becomes important to find the exact etiology and classification of the disease and to use the appropriate preventive and treatment measures. Despite its importance in the dermatological practice, very few Indian studies have been done till date to investigate the epidemiological trends, etiology, and treatment options for hand eczema. In this review, we tried to find the etiology, epidemiology, and available treatment modalities for chronic hand eczema patients.

show abstract

“…Overexpression of a human SC chymotryptic enzyme transgene in suprabasal epidermal keratinocytes of mice led to the development of AD-like skin starting at the age of 7 – 8 weeks or older [63]. …”

Section: Inflammatory Diseasementioning

confidence: 99%

Animal models of skin disease for drug discovery

Avci

Sadasivam

Gupta

et al. 2013

Expert Opinion on Drug Discovery

103

View full text Add to dashboard Cite

Introduction Discovery of novel drugs, treatments, and testing of consumer products in the field of dermatology is a multi-billion dollar business. Due to the distressing nature of many dermatological diseases, and the enormous consumer demand for products to reverse the effects of skin photodamage, aging, and hair loss, this is a very active field. Areas covered In this paper, we will cover the use of animal models that have been reported to recapitulate to a greater or lesser extent the features of human dermatological disease. There has been a remarkable increase in the number and variety of transgenic mouse models in recent years, and the basic strategy for constructing them is outlined. Expert opinion Inflammatory and autoimmune skin diseases are all represented by a range of mouse models both transgenic and normal. Skin cancer is mainly studied in mice and fish. Wound healing is studied in a wider range of animal species, and skin infections such as acne and leprosy also have been studied in animal models. Moving to the more consumer-oriented area of dermatology, there are models for studying the harmful effect of sunlight on the skin, and testing of sunscreens, and several different animal models of hair loss or alopecia.

show abstract

Epidermal Overexpression of Stratum Corneum Chymotryptic Enzyme in Mice: A Model for Chronic Itchy Dermatitis

Cited by 153 publications

References 25 publications

Kallikreins – The melting pot of activity and function

Kallikreins – The melting pot of activity and function

Hand eczema

Animal models of skin disease for drug discovery

Contact Info

Product

Resources

About