Epidermal Lipids and the Intercellular Pathway

Wertz, Philip W.

doi:10.1007/978-3-662-45013-0_2

Cited by 2 publications

(2 citation statements)

References 40 publications

(47 reference statements)

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“…Furthermore, these discoidal structures are encapsulated in vesicles. The morphology and structure of the LBms observed in our Cryo‐TEM images are quite similar to those of the epidermal lamellar bodies observed by other authors in electron micrographs . The LBms, similarly to epidermal lamellar bodies, is organized in a lipid bilayer that contains discoidal lamellar structures and is also similar in structure to bicosomes previously described in other studies .…”

Section: Discussionsupporting

confidence: 89%

Sorption–desorption test for functional assessment of skin treated with a lipid system that mimics epidermal lamellar bodies

Moner

Fernández²,

Pozo

et al. 2017

Contact Dermatitis

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Section: Discussionsupporting

confidence: 89%

Sorption–desorption test for functional assessment of skin treated with a lipid system that mimics epidermal lamellar bodies

Moner

Fernández²,

Pozo

et al. 2017

Contact Dermatitis

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“…Most of these retardants reported had the common feature: they formed H-bond crosslinking with ceremides 6, which possess the strongest H-bonding capability in the SC (11). It was found by Roberts et al that the main determinant of solute diffusion across SC was H-bonding, and the presence of zero to two groups having the most remarkable effect on the diffusion coefficient (12).…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydroxyl Groups and Rigid Structure in 1,4-Cyclohexanediol on Percutaneous Absorption of Metronidazole

et al. 2014

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Abstract. In a previous study, a synergistic retardation effect of 1,4-cyclohexanediol and 1,2-hexanediol on percutaneous absorption and penetration of metronidazole (MTZ) was discovered. A complex formation between 1,4-cyclohexanediol and 1,2-hexanediol was proposed to be responsible for the observed effect. The objective of this study was to investigate the necessity of hydroxyl group and the ring structure in 1,4-cyclohexanediol on percutaneous absorption and penetration of MTZ. Eleven formulations were studied in an in vitro porcine skin model using glass vertical Frans Diffusion Cell. 1,4-Cyclohexanediol was changed into 1,4-cyclohexanedicarboxylic acid, trans (and cis)-1,2-cyclohexanediol and 1,6-hexanediol, respectively, to study if H-bonding or ring structure would influence the retardation effect. MTZ was applied at infinite dose (100 mg), which corresponded to 750 μg of MTZ. Based on modifier ratios (MR) calculated by the flux values, the retardation effect on percutaneous absorption and penetration of MTZ was found in the formulations containing 1,4-cyclohexanedicarboxylic acid or cis-1,2-cyclohexanediol (MR values were 0.47 for which only contains 1,4-cyclohexanedicarboxylic acid, 0.74 for the formulation containing both 1,4-cyclohexanedicarboxylic acid and 1,2-hexanediol, and 0.90 for the formulation containing cis-1,2-cyclohexanediol and 1,2-hexanediol, respectively). The results showed that the hydroxyl group and structure of 1,4-cyclohexanediol played a significant role in retardation effects and provided valuable insight on the mechanisms of retardation effect through structure-activity relationships.

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Epidermal Lipids and the Intercellular Pathway

Cited by 2 publications

References 40 publications

Sorption–desorption test for functional assessment of skin treated with a lipid system that mimics epidermal lamellar bodies

Sorption–desorption test for functional assessment of skin treated with a lipid system that mimics epidermal lamellar bodies

Effect of Hydroxyl Groups and Rigid Structure in 1,4-Cyclohexanediol on Percutaneous Absorption of Metronidazole

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