Epidermal Langerhans cells express Ia antigens

Klareskog, Lars; Tjernlund, U; Forsum, Urban; Peterson, Per A.

doi:10.1038/268248a0

Cited by 442 publications

(114 citation statements)

References 14 publications

Supporting

Mentioning

108

Contrasting

Order By: Relevance

“…All of these populations express easily detectable MHC class II antigens (1,24,25) and all appear to be bone marrow-derived, as indicated by the expression of the T 2 0 0 antigen; none of these populations show reactivity when stained for nonspecific esterase. Some minor differences between the DC populations were noted.…”

Section: Discussionmentioning

confidence: 99%

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.

Sertl¹,

Takemura²,

Tschachler³

et al. 1986

The Journal of Experimental Medicine

340

184

View full text Add to dashboard Cite

In this study, we identified a population of dendritic cells (DC) that exists throughout human and mouse pulmonary tissues, including the trachea, bronchi, alveoli, and visceral pleura. In human tissue, these DC were shown to be positive for HLA-DR and T200 antigens. In the mouse, the DC expressed not only Ia and the T200 antigen, but also Fc-IgG and C3bi receptors. Unlike alveolar macrophages, the DC were negative for nonspecific esterase staining and shared ultrastructural similarities with the DC described by Steinman (1), and with Langerhans' cells, even though they did not contain Birbeck granules. We were able to demonstrate that mouse pulmonary DC function in antigen presentation, as observed with the other DC. Thus, the respiratory tract contains DC that are capable of functioning in antigen presentation and that may be important in pulmonary immune responses.

show abstract

Section: Discussionmentioning

confidence: 99%

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.

Sertl¹,

Takemura²,

Tschachler³

et al. 1986

The Journal of Experimental Medicine

340

184

View full text Add to dashboard Cite

show abstract

“…According to their CD1a phenotype, these cells were identified as epidermal Langerhans cells (Klareskog et al 1977;Krenacs et al 1993;Moseley et al 1997). Langerhans cells play an important role in the pathogenesis of contact dermatitis and in various other inflammatory dermatoses.…”

Section: Discussionmentioning

confidence: 99%

The Vesicular Monoamine Transporter 2 (VMAT2) Is Expressed by Normal and Tumor Cutaneous Mast Cells and Langerhans Cells of the Skin but Is Absent from Langerhans Cell Histiocytosis

Anlauf

Schäfer

Depboylu

et al. 2004

J Histochem Cytochem.

View full text Add to dashboard Cite

S U M M A R YMonoamine storage in secretory granules is mediated by the vesicular monoamine transporters 1 and 2 (VMAT1 and VMAT2). The aim of our study was to identify monoamine-handling normal and neoplastic inflammatory cells in the skin by their expression of VMAT1 and VMAT2. Normal skin from various parts of the body, as well as 21 cases of cutaneous mastocytosis and 10 cases of cutaneous Langerhans cell histiocytosis were analyzed by immunohistochemistry, radioactive in situ hybridization, and doublefluorescence confocal microscopy. VMAT2-positive cells in the subepidermal layer were

show abstract

“…Initial immunosurveillance of LCMV infection is mediated by CTLs. However, this response may lead to selection of LCMV variants that carry mutations in the relevant CTL epitopes and, therefore, can elude cytotoxic responses (1,2). Antibody responses are also essential for long-term protection.…”

Section: Viral Immunosuppression: Disabling the Guardsmentioning

confidence: 99%

CD1a and langerin: acting as more than Langerhans cell markers

Mizumoto

Takashima²

2004

J. Clin. Invest.

View full text Add to dashboard Cite

Langerhans cells (LCs) represent a unique DC subset populating the outermost body surface, i.e., the epidermis. Although CD1a and langerin (CD207) are used as specific markers to distinguish LCs from other DC subsets, their immunological functions have remained mostly unknown. A new paper (see the related article beginning on page 701) demonstrates that LCs utilize these markers to induce cellular immune responses to Mycobacterium leprae: CD1a mediates the presentation of nonpeptide antigens to T cells, while langerin facilitates uptake of microbial fragments and perhaps their delivery to a specialized subcellular compartment.

show abstract

Epidermal Langerhans cells express Ia antigens

Cited by 442 publications

References 14 publications

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.

The Vesicular Monoamine Transporter 2 (VMAT2) Is Expressed by Normal and Tumor Cutaneous Mast Cells and Langerhans Cells of the Skin but Is Absent from Langerhans Cell Histiocytosis

CD1a and langerin: acting as more than Langerhans cell markers

Contact Info

Product

Resources

About