Epidermal, hepatocellular and cholangiocellular carcinomas in brown bullheads, Ictalurus nebulosus, from industrially polluted black river, Ohio

Harshbarger, John C.; Cullen, Linda J.; Calabrese, Michael J.; Spero, Phyllis M.; Baumann, Paul C.; Parland, William K.

doi:10.1016/0141-1136(84)90148-x

Cited by 15 publications

(4 citation statements)

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“…Numerous studies have suggested an association between exposure to chemicals, most frequently PAHs, in the sediment of lakes and rivers and an increased prevalence of hepatic neoplasms in brown bullhead (Baumann et al, 1987Harshbarger, 1995, 1998;Brown et al, 1973;Harshbarger et al, 1984;Leadley et al, 1998;Pinkney et al, 2001Pinkney et al, , 2004aPyron et al, 2001;Smith et al, 1994). Susser (1986) suggests that although epizootiologic studies cannot prove cause and effect, the altered frequency or intensity of an effect caused by an intervention or remedial action can provide the strongest support possible for a causal hypothesis concerning a freeliving population.…”

Section: Extrinsic Factorsmentioning

confidence: 96%

“…Harshbarger et al (1984) reported one-third of brown bullhead collected from the industrially polluted Black River, Lorain, OH, had neoplasms of the skin and liver (or both). The elevated prevalence of neoplasms was attributed to the presence of 26 PAHs in the sediment, two of which were known mammalian carcinogens: benzo(a)pyrene and dibenz[a,h]anthracene; however, no statistical data were provided.…”

Section: Extrinsic Factorsmentioning

confidence: 97%

See 1 more Smart Citation

A historical perspective on the “fish tumors or other deformities” beneficial use impairment at Great Lakes Areas of Concern

Rafferty

Blazer

Pinkney

et al. 2009

Journal of Great Lakes Research

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Section: Extrinsic Factorsmentioning

confidence: 96%

Section: Extrinsic Factorsmentioning

confidence: 97%

A historical perspective on the “fish tumors or other deformities” beneficial use impairment at Great Lakes Areas of Concern

Rafferty

Blazer

Pinkney

et al. 2009

Journal of Great Lakes Research

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“…Areas of a gudgeon, Gobio gobio L., tumour (RTLA 219-Mawdesley-Thomas & Bucke 1967) as well as some areas of several brown bullhead lesions (RTLA 2623, 2624, 2626-Harshbarger et al 1984 resemble the menhaden squamous cell carcinoma, but these lesions all appear to be more well differentiated. The authors believe a diagnosis of squamous cell carcinoma is warranted for the menhaden lesion based on the derivation of the tumour from stratified squamous epithelium, the numerous atypical squamous cells, the abundance of mitotic figures and the absence of intercellular bridges between many cells.…”

mentioning

confidence: 99%

Squamous cell carcinoma in the gulf menhaden, Brevoortia patronus Goode

Fournie

Vogelbein

Overstreet

1987

Journal of Fish Diseases

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“…For the liver tumor clusters in tomcod (24,25), bullheads (26,27) sauger and walleyes (28), the epizootiological evidence is less strong, for a variety of reasons reviewed by Mix (29), but in my opinion it is sufficient to place these groups among the environmental oncozoons until proven otherwise.…”

mentioning

confidence: 99%

Oncozoons and the search for carcinogen-indicator fishes.

Dawe¹

1987

Environ Health Perspect

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This essay attempts to bring into perspective the importance of hereditary as well as environmental factors as potential causes of neoplasms in feral fishes. Concepts delineated by Knudson regarding hereditary cancers in man and experimental animals will probably be found operative in certain demographic units (oncozoons) among feral fishes bearing neoplasms. Hereditary factors include: antioncogenes (regulatory genes), which act as suppressors of neoplastic expression in homozygous, heterozygous, or hemizygous states, as well as constitutional (structural) genes that influence carcinogen activation or deactivation through enzyme gene products, genes that influence immunologic responses, and gene abnormalities that favor spontaneous or induced mutations.The two major classes of genes (oncogenes and antioncogenes) that influence the manifestation of cancers appear to operate through different mechanisms, but conceivable interactions have not been widely investigated, especially in tumor enzootics among feral fishes. Some explorations have been undertaken in the laboratory by Anders and collaborators in studies of suppressor genes (antioncogenes)and the cellular sarc gene (an oncogene) in melanophoromas in platyfish-swordtail hybrids and backcrosses. Some feral fish oncozoons that exhibit features of hereditary oncodemes as seen in man have been tentatively identified here as candidate systems to be studied more intensively in laboratories, particularly using cytogenetic analysis and breeding methods.In the search for carcinogen-indicator fish species in feral habitats, the traditional approach has been to survey fish populations with the aim of first finding enzootics of fish neoplasia. Advances in understanding carcinogen metabolism and the pharmacokinetics of carcinogens in fishes suggest an alternative approach, outlined herein, that could strengthen the rationale for using neoplasms in feral fishes as indicators of environmental carcinogens in aquatic environments.This volume is appropriately focused on mechanisms of pollutant action, and it has held steadfastly to that theme. We see from other papers that mechanisms can be of critical importance to our understanding of why particular carcinogens are selective for certain fish species and for particular cell phenotypes within a given species. Absent, however, has been consideration of the possible role (s)

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Epidermal, hepatocellular and cholangiocellular carcinomas in brown bullheads, Ictalurus nebulosus, from industrially polluted black river, Ohio

Cited by 15 publications

References 0 publications

A historical perspective on the “fish tumors or other deformities” beneficial use impairment at Great Lakes Areas of Concern

A historical perspective on the “fish tumors or other deformities” beneficial use impairment at Great Lakes Areas of Concern

Squamous cell carcinoma in the gulf menhaden, Brevoortia patronus Goode

Oncozoons and the search for carcinogen-indicator fishes.

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