Epidermal Growth Factor Receptor-Targeted Delivery of a Singlet-Oxygen Sensitizer with Thermal Controlled Release for Efficient Anticancer Therapy

Chen, Juanjuan; Li, Dongyao; Huo, Beibei; Zhang, Fengling; Zhao, Xuan; Yuan, Gankun; Chen, Dan; Song, Meiru; Xue, Jinping

doi:10.1021/acs.molpharmaceut.9b00670

Cited by 14 publications

(12 citation statements)

References 34 publications

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“…The rate constant of 1 O 2 generation was calculated to be 0.03971 based on a reported method using 1,3-diphenylisobenzofuran (DPBF) as the reference (Figure S10). As seen in Figure F and S11, the efficiency of 1 O 2 generation was greatly enhanced in Hb-contained groups. These results demonstrated that Hb had a major contribution to the 1 O 2 generation.…”

Section: Results and Discussionmentioning

confidence: 76%

A Robust Oxygen-Carrying Hemoglobin-Based Natural Sonosensitizer for Sonodynamic Cancer Therapy

et al. 2021

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The development of novel sonosensitizers with outstanding reactive oxygen (ROS) generation capacity and great biocompatibility poses a significant challenge for the clinical practice of sonodynamic therapy (SDT). In this work, hemoglobin (Hb) with natural metalloporphyrin was first shown to possess great potential as a sonosensitizer. Compared with traditional organic sonosensitizers, Hb had satisfactory sono-sensitizing efficiency because four the porphyrin molecules were separated by four polypeptide chains. This effectively avoided the problem of low ROS quantum yield caused by the stacking of hydrophobic porphyrins. Meanwhile, Hb is an efficient and safe oxygen carrier that may release O2 at hypoxic tumors site, which improved tumor oxygenation and subsequently enhanced SDT efficacy. Therefore, Hb was integrated with zeolitic imidazolate framework 8 (ZIF-8) to form a nanoplatform that demonstrated a potent suppression effect on deep-seated tumors under ultrasound irradiation.

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Section: Results and Discussionmentioning

confidence: 76%

A Robust Oxygen-Carrying Hemoglobin-Based Natural Sonosensitizer for Sonodynamic Cancer Therapy

et al. 2021

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“…[23] Finally,t his methodology was also applied in the derivatization of Erlotinib, whichisoften used for molecular targeted therapy, to yield 5k.A so bserved in almosta ll cases, the PcAACr eaction showede xcellent selectivity,c onversions,a nd yields,w hich represents an important finding fort he preparation of 1,4-substituted 1,2,3-triazolesw ithout the use of copper. [24] In addition, to illustrate the practicability of the reaction protocol, the PcAACr eaction could be scaled up to 1g by using 0.5 mol of the each reactant, giving as atisfactory yield of 88 % [c] [(piq) 2 Ir(acac)] DCM 6/RT,a ir,w hite LED NR 19 [d] [(piq) 2 Ir(acac)] DCM 6/RT,a ir,w hite LED NR catalystr etains its catalytic activity during continuous recycling experiments (four cycles) with considerable selectivity and efficiency. The development of solars ynthesis for organic photochemistry is ah ighly significant advance [25] because sunlight is effectively an inexhaustible energy source.…”

Section: Resultsmentioning

confidence: 99%

Visible‐Light‐Mediated Click Chemistry for Highly Regioselective Azide–Alkyne Cycloaddition by a Photoredox Electron‐Transfer Strategy

Liao

et al. 2020

Chemistry A European J

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Click chemistry focuseso nt he development of highly selectiver eactionsu sing simple precursors for the exquisite synthesis of molecules. Undisputedly,t he Cu I -catalyzed azide-alkyne cycloaddition (CuAAC)i so ne of the most valuable examples of click chemistry, but it suffersf rom some limitations as it requires additional reducing agents and ligands as well as cytotoxic copper. Here, we demonstrate an ovel strategy for the azide-alkyne cycloaddition reaction that involves ap hotoredox electron-transfer radical mechanism insteado ft he traditional metal-catalyzed coordination process.T his newly developed photocatalyzeda zidealkyne cycloaddition reaction can be performed under mild conditions at room temperature in the presence of air and visiblel ight ands hows good functional group tolerance, excellenta tom economy, highy ields of up to 99 %, and absolute regioselectivity,a ffordingavariety of 1,4-disubstituted 1,2,3-triazole derivatives, including bioactive molecules and pharmaceuticals. The use of ar ecyclable photocatalyst,s olar energy, andw ater as solventm akes this photocatalytic systems ustainable and environmentally friendly.M oreover, the azide-alkyne cycloadditionr eaction could be photocatalyzed in the presenceo fametal-free catalyst with excellent regioselectivity,w hich represents an important development for click chemistry and should find versatile applicationsi n organic synthesis, chemical biology,and materials science.[a] Dr.Scheme1.Structures of 1,4-disubstituted 1,2,3-triazoles and strategies for their synthesis. (a) Bioactive molecules and pharmaceuticals based on the 1,4-disub-stituted1 ,2,3-triazole core. (b) The reported methodsf or the synthesis of 1,4-disubstituted 1,2,3-triazoles and the mechanism for the traditional metal-catalyzed AAC reaction. (c)Our designed strategy for the AAC reaction through photoredox electron-transfer cyclization and its features andadvantages, as well as the proposed mechanism.( Figure 1a). The recyclability of the photocatalystwas also evaluated and the resultsd emonstrate that the photocatalyst is air-and moisture-tolerant and can be readily recovered after use and reused severalt imes. Figure 1b shows that the photo-Scheme2.Scope of the PcAAC reaction.Standardreagents and conditions: Azide (0.2 mmol), alkyne (0.2 mmol), photocatalyst (5 mol %), DCM (2.0 mL), RT, air,6 -12 h, 26 Ww hite LED irradiation.

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Section: Introductionmentioning

confidence: 99%

“…These factors, together with other pro-angiogenic factors, they promote the growth of excessive tumor vasculature in tumors. Erlotinib (ERL), a tyrosine inhibitor that specifically targets tumor cells, 11,12 has been shown to normalize tumor vasculature. 13−16 Normalization of blood vessels can repair the structure and function of tumor vasculature by correcting angiogenesis signals.…”

Section: Introductionmentioning

confidence: 99%

Reshaping Tumor Blood Vessels to Enhance Drug Penetration with a Multistrategy Synergistic Nanosystem

Liu

Cheng

2020

Mol. Pharmaceutics

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Due to the abnormal tumor vasculature and dense stroma, there is limited tumor perfusion in the immunosuppressive tumor microenvironment (TME). In order to reshape tumor blood vessels and enhance the penetration of anticancer drugs into the tumor tissue, an anionic liposome nanosystem with a “sandwich” structure was prepared. The chemotherapeutic agent topotecan (TPT) was encapsulated in the lipid hydrophilic layer, and the sensitizer indocyanine green (ICG) was loaded into the hydrophobic layer. In addition, the positively charged vascular normalization drug erlotinib (ERL) was adsorbed to the outermost layer of the microenvironment. The nanosystem showed superior tumor permeability in vitro/in vivo experiments compared with the ERL-treated group. The nanosystem entered the tumor through normalization of blood vessels after the action of ERL. Ultrasound treatment improves the vascular permeability, allowing the nanoparticles to penetrate blood vessels and reach tumor cells. Finally, in addition to cytotoxic effects, TPT can also down-regulate the expression of HIF-1α and so prolong the vascular normalization time. These experimental results showed that the nanosystem effectively improves the tumor microenvironment. This work indicates the great potential of vascular normalization combined with sonodynamic therapy and chemotherapy to enhance efficiency.

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Epidermal Growth Factor Receptor-Targeted Delivery of a Singlet-Oxygen Sensitizer with Thermal Controlled Release for Efficient Anticancer Therapy

Cited by 14 publications

References 34 publications

A Robust Oxygen-Carrying Hemoglobin-Based Natural Sonosensitizer for Sonodynamic Cancer Therapy

A Robust Oxygen-Carrying Hemoglobin-Based Natural Sonosensitizer for Sonodynamic Cancer Therapy

Visible‐Light‐Mediated Click Chemistry for Highly Regioselective Azide–Alkyne Cycloaddition by a Photoredox Electron‐Transfer Strategy

Reshaping Tumor Blood Vessels to Enhance Drug Penetration with a Multistrategy Synergistic Nanosystem

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