Epidermal growth factor receptor copy number in potentially malignant oral disorders and oral squamous cell carcinoma: a short communication and preliminary study

Bagán, José; Mata‐Roig, Manuel; Cortio-Gimeno, Julio; Murillo-Cortés, Judith; Hens-Aumente, Elena; Poveda-Roda, Rafael; Bagán, Leticia

doi:10.1111/j.1600-0714.2012.01137.x

Cited by 10 publications

(13 citation statements)

References 23 publications

(30 reference statements)

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“…1) It is present both in serum and saliva (soluble EGFR) . 2) Its tissue overexpression has been detected during the cancerogenesis of the oral mucosa . 3) It is frequently overexpressed in OSCC and in premalignant oral lesions .…”

Section: Introductionmentioning

confidence: 99%

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Epidermal growth factor receptor detection in serum and saliva as a diagnostic and prognostic tool in oral cancer

et al. 2017

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Section: Introductionmentioning

confidence: 99%

“…2) Its tissue overexpression has been detected during the cancerogenesis of the oral mucosa . 3) It is frequently overexpressed in OSCC and in premalignant oral lesions . 4) Its tissue overexpression is significantly associated with poor prognosis in OSCC .…”

Section: Introductionmentioning

confidence: 99%

Epidermal growth factor receptor detection in serum and saliva as a diagnostic and prognostic tool in oral cancer

et al. 2017

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“…Consequently, EGFR can be considered as a marker of cell epithelial proliferation, of OED, and as the onset of progression from dysplasia to OSCC. 43 Bagan et al 26 reported that EGFR CNG is a potential marker for predicting malignant transformation of OED. The authors noted that EGFR CNG was significantly higher in malignant lesions and in non-homogeneous leukoplakia compared to homogeneous leukoplakia.…”

Section: Detection Methods Of Egfr In Oral Cancermentioning

confidence: 99%

“…3,17,31,35,49 In oral cancer specific tests to evaluate deletions, silent mutations or changes at amino acid level encoded in exons 18 to 21 have been used. 33 Bagan et al 26 studied the genomic amplification of EGFR in frozen tissue samples. Using Real-Time-PCR, they found a high rate of EGFR CNG in oral cancer when compared with potentially malignant lesions.…”

Section: Detection Methods Of Egfr In Oral Cancermentioning

confidence: 99%

“…9 In OSCC, there has been observed an increase in EFGR expression in the cell plasma membrane of oral keratinocytes, 26 resulting in a poor prognosis, high recurrence and lower survival rate. 9,16,26 EGFR mutations EGFR mutations can be classified according to the specific region of the receptor they affect: extracellular, intracellular or TK domain. Deletion type mutations affecting the sequence encoding the N-terminal region, deletions of exons 2-7, 12-13, 14-15, 25-27, 25-28; duplications of exons 2-7, 18-21, and point mutations have been described.…”

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Dysregulation and detection methods of EGFR in oral cancer. A narrative review.

Somarriva

Fernández²,

Candia

et al. 2016

J Oral Res

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Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, with an intracellular domain and tyrosine kinase function (TK) involved in cell proliferation. Dysfunctions in EGFR signaling pathways have been associated with oral malignant tumors such as oral squamous cell carcinoma (OSCC). Dysfunctions of EGFR may result from: increased EGF ligand; EGFR overexpression and copy number gain of the EGFR gene (EGFR CNG); EGFR mutations; failure in the downregulation of EGFR; and EGFR crosstalk. Of these alterations, overexpression of EGFR is by far the most studied dysfunction in OSCC. Clinicians should identify possible alterations of EGFR in the oral mucosa of patients, as EGFR can act as a biomarker for the diagnosis and prognosis of OSCC. Currently, there are several methods and techniques for detecting EGFR. Immunohistochemistry (IHC), fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR), are used to identify overexpression of EGFR, EGFR CNG and EGFR mutations, respectively. Detection of EGFR as a biomarker is key to identify any oral malignant transformation. Consequently, it becomes imperative to implement a non-invasive and inexpensive method of early diagnosis for OSCC in clinical practice.

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An active surveillance program in oral preneoplasia and translational oncology benefit

Archibald

Buryska

Ondrey

2021

Laryngoscope Investig Oto

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Objective We desired to establish an active surveillance clinic for head and neck cancer. In this review we examined. Methods We examined the natural history of human oral carcinogenesis, the types of preneoplastic lesions, and efforts at oral chemoprevention over the past decades for presentation here. Results We established a clinic and program for patients with oral premalignant lesions approximately over 15 years ago based on an unmetneed for this service. We have completed over 4000 outpatient visits for this cohort and have a place for referrals of difficult oral lesions. We have leveraged this population for multiple federally funded trials on oral cancer prevention as well as specimen banking. Conclusion There is need for routine active surveillance for oral preneoplastic conditions in patients at high risk for conversion to cancer. There are no effective durable treatment or preventions for these individuals and we have attempted to fill this unmet need with our program.

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Epidermal growth factor receptor copy number in potentially malignant oral disorders and oral squamous cell carcinoma: a short communication and preliminary study

Abstract: The EGFR copy number may be a useful biomolecular marker to differentiate PMODs from OSCC. The EGFR was higher in non-homogeneous leukoplakias and in the advanced stages of OSCC.

Cited by 10 publications

References 23 publications

Epidermal growth factor receptor detection in serum and saliva as a diagnostic and prognostic tool in oral cancer

Epidermal growth factor receptor detection in serum and saliva as a diagnostic and prognostic tool in oral cancer

Dysregulation and detection methods of EGFR in oral cancer. A narrative review.

An active surveillance program in oral preneoplasia and translational oncology benefit

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