Epidermal growth factor receptor and KRAS mutations in lung adenocarcinoma: A retrospective study of the Lebanese population

Abstract. The aim of the present study was to determine the prevalence of epidermal growth factor receptor mutations (EGFRmut) in the Gulf region (GR) and its correlation with demographic and clinical characteristics. A multisite retrospective study was conducted, including institutions from Saudi Arabia, the United Arab Emirates and Qatar. All consecutive patients with non-small-cell lung cancer tested for EGFRmut were eligible. Data collected included demographic information, disease characteristics and EGFR test results. Data on 230 patients were obtained. The median age of the patients was 61 years (range, 26-87 years); 169 patients (69.83%) were male and 204 (88.7%) were Arab. The histological subtype was adenocarcinoma in 191 (83.4%) and squamous cell carcinoma in 21 cases (9.17%). Overall, EGFRmut were detected in 66 patients (28.7%), with a prevalence of 32.46% in adenocarcinoma. No squamous cell carcinomas were found to harbor EGFRmut. The univariate and multivariate analyses revealed that female gender, non-smoking status and adenocarcinoma subtype were significant predictors for EGFRmut. There was no difference between Arabs and non-Arabs. In conclusion, to the best of our knowledge, this is the first multisite study to report the prevalence of EGFRmut in the GR population, which was found to be higher compared with that in Western, but lower compared with that in Far Eastern populations. Studies evaluating the efficacy of targeted therapy in this population are underway.

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“…As expected, patients who received TKI treatment had a better outcome compared with the remaining patients (11,12).…”

Section: Discussionsupporting

confidence: 51%

“…In another study on 106 Lebanese patients with adenocarcinoma, only 8.5% harbored EGFRmut (11). Variations between countries in this region may be attributed to potential variations in ethnicity and prevalence of smoking.…”

Section: Discussionmentioning

confidence: 99%

Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region

Jazieh

Jaafar

Jaloudi

et al. 2015

Molecular and Clinical Oncology

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“…In the 9 studies that reported smoking status, approximately 41.1% of patients had never smoked (Table 2 ). We determined that 85.8% of the patients included in the studies had an adenocarcinoma; however, two studies [ 10 , 18 ] only reported on patients with this subtype (Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…(%) Other subtypes No. (%) Overall 1043 (85.8%) 172 (14.2%) Lebanon Naderi et al [ 9 ] 182 (90.5%) 19 (9.5%) Fakhruddin et al [ 10 ] 106 (100%) 0 (0%) Kattan et al [ 11 ] 157 (92.4%) 13 (7.6%) Egypt Zaki et al [ 12 ] 23 (46%) 27 (54%) Turkey Unal et al [ 13 ] 32 (66.7%) 16 (33.3%) Bircan et al [ 14 ] 14 (56%) 11 (44%) Saudi Arabia (SA) Al-Kuraya et al [ 15 ] 26 (55.3%) 21 (44.7%) SA-UAE-Qatar Jazieh et al [ 16 ] 191 (83.0%) 39 (17.0%) SA-UAE-Egypt Jazieh et al [ 17 ] 175 (87.1%) 26 (12.9%) Morocco Errihani et al [ 18 ] 137 (100%) 0 (0%) …”

Section: Resultsmentioning

confidence: 99%

EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis

2018

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BackgroundOur goal was to investigate the prevalence of the epidermal growth factor receptor (EGFR) mutation in Middle East and African countries and to compare its prevalence with that shown in other populations.MethodsWe used PubMed and the Cochrane Library databases to conduct a literature search using the terms “[EGFR] AND [mutation] AND [Non Small Cell Lung Cancer] AND [Middle East OR Africa].” We assessed studies published in English and French from 2004 until 2016.ResultsTen relevant studies were included in this systematic review. Overall, 1215 patients with non-small cell lung cancer (NSCLC) were included in this analysis. The overall ratio of male to female patients was 2.15. Of total patients included, 41.1% had never smoked and 85.8% had been diagnosed with adenocarcinoma. In 8 of the 10 studies, polymerase chain reaction (PCR) analyses were conducted to identify EGFR mutations. In total, 257 patients had an EGFR mutation, corresponding to a prevalence of 21.2%. The most frequent abnormality detected in all of the studies was in exon 19. In addition, all studies concluded the presence of a correlation between EGFR mutation status and female sex, non-smoking status, and adenocarcinoma subtype.ConclusionsThe EGFR mutation frequency in Middle East and African patients is higher than that shown in white populations but still lower than the frequency reported in Asian populations.

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“…This mutation was reported to be the most common mutation in the Lebanese population, which is of a closely related ethnic background to Syria, and share a similar environment and lifestyle. [ 18 ] Exon19del EGFR mutations overlap with the start of the kinase domain in the protein and have been established as responsive mutants to TKI. [ 19 ] In addition, the L861Q mutation in exon 18 is also associated with good response to TKI, and was found in one patient.…”

Section: Discussionmentioning

confidence: 99%

Epidermal growth factor receptor mutations in nonsmall cell lung carcinoma patients in Kuwait

Al-Temaimi

Kapila

Al-Mulla

et al. 2016

J Cytol

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Context:Nonsmall cell lung carcinoma (NSCLC) is the most frequently diagnosed form of lung cancer in Kuwait. NSCLC samples from Kuwait have never been screened for epidermal growth factor receptor (EGFR) gene aberration, which is known to affect treatment options.Aims:This study investigated the feasibility of using fine-needle aspiration (FNA) material for mutational screening, and whether common EGFR mutations are present in NSCLC samples from Kuwait.Settings and Design:Eighteen NSCLC samples from five Kuwaitis and 13 non-Kuwaitis were included in this study.Materials and Methods:DNA was extracted from FNA cell blocks and screened for EGFR gene mutations using peptide nucleic acid (PNA)-clamp assay, and EGFR gene amplification using fluorescent in situ hybridization (EGFR-FISH). EGFR protein expression was assessed using immunohistochemistry.Results:Five EGFR mutations were detected in five non-Kuwaiti NSCLC patients (27.8%). EGFR gene amplification was evident in 10 samples (55.5%) by direct amplification or under the influence of chromosomal polysomy. Four samples had EGFR mutations and EGFR gene amplification, out of which only one sample had coexisting EGFR overexpression.Conclusions:Given the evidence of EGFR gene alterations occurring in NSCLC patients in Kuwait, there is a need to incorporate EGFR gene mutational screen for NSCLC patients to implement its consequent use in patient treatment.

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Epidermal growth factor receptor and KRAS mutations in lung adenocarcinoma: A retrospective study of the Lebanese population

Cited by 18 publications

References 44 publications

Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region

Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region

EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis

Epidermal growth factor receptor mutations in nonsmall cell lung carcinoma patients in Kuwait

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