Epidermal growth factor-induced protection of tumour cell susceptibility to cytolysis

Nouri, A. M. E.; Hussain, R.F.; Oliver, R.T.D.

doi:10.1016/0959-8049(95)00120-4

Cited by 3 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Attempts to establish links between the expression of ErbB/HER family members and MHC molecules have been the subject of study for many years ( Nouri et al, 1995 ; Nistico et al, 1997 ; Lollini et al, 1998 ). Using a forced-expression approach, Herrmann et al (2004) demonstrated that the expression of ErbB2/HER2 was associated with decreases in MHCI and other components of the APM.…”

Section: Linking Erbb/her To the Mhcmentioning

confidence: 99%

Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model

et al. 2016

View full text Add to dashboard Cite

Advances in molecular pathology have changed the landscape of oncology. The ability to interrogate tissue samples for oncogene amplification, driver mutations, and other molecular alterations provides clinicians with an enormous level of detail about their patient’s cancer. In some cases, this information informs treatment decisions, especially those related to targeted anti-cancer therapies. However, in terms of immune-based therapies, it is less clear how to use such information. Likewise, despite studies demonstrating the pivotal role of neoantigens in predicting responsiveness to immune checkpoint blockade, it is not known if the expression of neoantigens impacts the response to targeted therapies despite a growing recognition of their diverse effects on immunity. To realize the promise of ‘personalized medicine’, it will be important to develop a more integrated understanding of the relationships between oncogenic events and processes governing anti-tumor immunity. One area of investigation to explore such relationships centers on defining how ErbB/HER activation and signal transduction influences antigen processing and presentation.

show abstract