Epidermal growth factor, growth differentiation factor-15, and survivin as novel biocompatibility markers in children on chronic dialysis

Bargenda, Agnieszka; Musiał, Kinga; Zwołińska, Danuta

doi:10.1080/1354750x.2016.1201534

Cited by 7 publications

(4 citation statements)

References 21 publications

(4 reference statements)

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“…Also, the diagnostic performance of GDF-15 as a marker of inflammation in CKD was comparable to CRP and better than ferritin that is mostly elevated by iron overload associating CKD, qualifying GDF-15 as a surrogate marker of inflammatory status in CKD. Similar results were found by Bargenda et al [ 27 ], Thorsteinsdottir et al [ 28 ]…”

Section: Discussionsupporting

confidence: 92%

GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease

Farag,

Mousa,

Elsayed

et al. 2023

Ital J Pediatr

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Background Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and associated with poor clinical outcomes. We evaluated the diagnostic validity of growth differentiation factor-15 (GDF-15) and hepcidin as it is not clear if they are useful as a biomarkers of anaemia among non-dialysis CKD egyptian patients. Method An analytical cross-sectional study was conducted among non-dialysis CKD patients (n = 60) and apparently healthy controls (n = 28) at Minia University maternity & children Hospital. Serum levels of GDF-15 and hepcidin were determined. Predictive logistic regression models were built and post estimation receiver operator characteristics were determined to evaluate diagnostic validity of hepcidin and GDF-15 for iron deficiency anaemia. Results Hepcidin and GDF-15 are significantly higher in cases than control p value (0.047 < 0.0001) respectively. The predictive value of diagnosing anaemia among CKD patients using hepcidin and GDF-15 was 72.0%, 70.0%. There was a weak negative correlation between hepcidin levels and glomerular filtration rate GFR (r = -.175, p = 0.105) in CKD patients, and significant correlation between serum GDF-15 and haemoglobin (r = -0.897, p < 0.0001), ferritin (r = 0.489, P < 0.000), Iron (r = -0.314, P = 0.002), CRP (r = 0.409, P < 0.0001). Conclusion Hepcidin and GDF-15 is a potential biomarker for predicting anaemia connected with inflammation among CKD Egyptian patients.

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Section: Discussionsupporting

confidence: 92%

GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease

Farag,

Mousa,

Elsayed

et al. 2023

Ital J Pediatr

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“…Urinary GDF-15 levels have also been shown to be elevated and negatively correlated with eGFR in adults with diabetes [8]. Increasing data exists on GDF-15 in children, but only one study on children with kidney disease is published and demonstrates elevated GDF-15 levels in patients on hemodialysis and peritoneal dialysis [9].…”

Section: Introductionmentioning

confidence: 99%

Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation

et al. 2020

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Growth differentiation factor 15 (GDF-15) is strongly associated with cardiovascular disease (CVD). The aim of our study was to evaluate plasma and urinary levels of GDF-15 after pediatric renal transplantation (Rtx) and in children with chronic kidney disease (CKD) and its associations to cardiovascular risk factors. In this cross-sectional study, GDF-15 was measured in plasma and urine from 53 children with a renal transplant and 83 children with CKD and related to cardiovascular risk factors (hypertension, obesity, and cholesterol) and kidney function. Forty healthy children served as a control group. Plasma levels of GDF-15 (median and range) for a Tx (transplantation) cohort, CKD cohort, and healthy controls were, respectively, 865 ng/L (463-3039 ng/L), 508 ng/L (183-3279 ng/L), and 390 ng/L (306-657 ng/L). The CKD and Tx cohorts both had significantly higher GDF-15 levels than the control group (p<0.001). Univariate associations between GDF-15 and hyperuricemia (p<0.001), elevated triglycerides (p=0.028), low HDL (p=0.038), and obesity (p=0.028) were found. However, mGFR (p<0.001) and hemoglobin (p<0.001) were the only significant predictors of GDF-15 in an adjusted analysis. Urinary GDF-15/creatinine ratios were 448 ng/mmol (74–5013 ng/mmol) and 540 ng/mmol (5–14960 ng/mmol) in the Tx cohort and CKD cohort, respectively. In the CKD cohort, it was weakly correlated to mGFR (r=−0.343, p=0.002). Plasma levels of GDF-15 are elevated in children with CKD and after Rtx. The levels were not associated with traditional cardiovascular risk factors but strongly associated with renal function.

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“…After confirming the absence of multicollinearity, we performed multivariate analysis for each biomarker while including the confirmed adjustment variables. Previous research has demonstrated that the biomarkers in our study interact with each other [ 15 , 26 – 28 ]. Therefore, we have chosen to analyze each biomarker individually rather than using a multivariate regression analysis.…”

Section: Methodsmentioning

confidence: 69%

Clinical significance of urinary inflammatory biomarkers in patients with IgA nephropathy

Yoon,

Kim,

Jung

et al. 2024

BMC Nephrol

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Background IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis, although the definitive markers are unknown. We aimed to investigate the clinical significance of urinary cytokines in patients with IgAN. Methods From 2009 to 2018, the patients were divided into three groups: IgAN (n = 191), disease control (n = 53), and normal control (n = 76). We used a multiplex enzyme-linked immunosorbent assay to measure 16 selected urinary inflammatory cytokines, evaluated the correlation between clinical and pathological features following regression analysis on progression. Results The IgAN group exhibited significantly different levels of urinary cytokines compared to the normal control and disease control groups. Urinary levels of B-cell-activating factor, vascular endothelial growth factor receptor-2, monocyte chemoattractant protein-1, C–X–C motif chemokine 10, C–X–C motif ligand 16, epidermal growth factor (EGF), endocan, endostatin, growth/differentiation factor-15 (GDF-15), interleukin-6 (IL-6), mannose-binding lectin, transferrin receptor, and kidney injury molecule-1 were significantly correlated with both the estimated glomerular filtration rate and urine protein–creatinine ratio. In a multivariate Cox regression analysis, urinary EGF (hazard ratio [HR] 0.40, 95% confidence interval [CI] 0.17–0.95, P = 0.04), GDF-15 (HR 2.45, 95% CI 1.01–5.94, P = 0.048), and IL-6 (HR 3.02, 95% CI 1.05–8.64, P = 0.04) were associated with progression in IgAN. Conclusions Urinary inflammatory biomarkers may serve as alternative predictive biomarkers in patients with IgAN. Further studies are needed to elucidate the physiological mechanisms and confirm the results.

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Epidermal growth factor, growth differentiation factor-15, and survivin as novel biocompatibility markers in children on chronic dialysis

Cited by 7 publications

References 21 publications

GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease

GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease

Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation

Clinical significance of urinary inflammatory biomarkers in patients with IgA nephropathy

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