Epidermal growth factor (EGF) and EGF receptor in hypospadias

Abstract

Objective To determine whether alterations in epidermalResults The median EGF density in foreskins obtained by circumcision was 75% (mean 73, se 2.1) compared growth factor (EGF), which plays a major role both in the masculinization of the genitourinary tract and in with 54% (mean 52, se 3.9) for tissue samples from patients with hypospadias (P<0.001); the mean EGFR wound healing, or EGF receptor (EGFR) expression are associated with hypospadias.was similar in both materials. Conclusion The mean EGF value was deficient in skin Patients and methods The prepuces from 22 children undergoing circumcision (median age 27 months, adjacent to hypospadias defects compared to normal phallic skin, suggesting that the inadequate expression range 5-87) and skin biopsies from 16 children undergoing surgery for hypospadias (median age 12 of EGF may be related to the aetiology of hypospadias and to possible wound complications following surgery months, range 3-57) were studied. Fourteen patients had distal, one had mid-shaft and one had penoscrotal for hypospadias. Keywords Hypospadias, epidermal growth factor, epiderhypospadias. Immunoperoxidase staining was carried out for EGF and EGFR and the density of the staining mal growth factor receptors, wound healing quantified using image cytometry by an operator unaware of the diagnosis. tiation of the mammalian reproductive tract and the

Risk Factors for the Development of Urethrocutaneous Fistula after Hypospadias Repair: A Retrospective Study

“…Surgical technique is thought to be a key factor, although a local deficit in growth factors may also play a role [16]. Local or systemic, adjuvant or neoadjuvant hormonal therapy has been proposed to reduce fistula development, but the results are controversial so far.…”

The microvessel density of the hypospadiac prepuce in children

“…The authors tried to explain the postoperative edema, poor wound healing leading to urethrocutaneous fistulae, and increased analgesia requirements in patients undergoing hypospadias surgery in terms of differences in tissue environment [6]. In a previous study, El-Galley et al [8] showed that mean epidermal growth factor was decreased in skin adjacent to hypospadias defects compared to normal phallic skin, and suggested that this may be related to the etiology of hypospadias and to possible wound complications postoperatively. The arterial blood supply of the hypospadiac prepuce is different than normal [3].…”

Hypospadias and endocrine disruption: is there a connection?

“…Full differentiation, however, requires the presence of testosterone (63), similar to the role of EGF to promote growth and differentiation of the mouse uterus and vagina (65). Reduced EGF density in foreskins was discovered in 16 children undergoing hypospadias surgery compared with 22 children undergoing circumcision (p = 0.001), although there was no reduction in mean EGF receptors (EGFR) (66). This suggests interference with receptor binding.…”