Epidermal fine structure in embryonic chicken skin during atypical differentiation induced by vitamin a in culture

Electron microscopic studies of xeroderma pigmentosum: unusual changes in the keratinocyte

“…In other words, the keratinocyte having abnormally dilated rough endoplasmic reticulum may be regarded as a keratinizing cell which has undergone a metaplastic transformation into a protein-secreting cell. Similar metaplastic changes have been reported in epidermal cells of embryonic chicken skin following culture with excess vitamin A (Fell, 1962;Jackson & Fell, 1963).…”

Adnexal Metaplasia in Carcinoma in situ of the Skin

“…In man, single goblet cells are present in the epidermally-derived stratified squamous epithelium of the conjunctiva. Fine structural studies of human fetal epidermis at 12 and 14 weeks have shown the presence of intracellular cytoplasmic vesicles (Breathnach & Wyllie 1965) similar in appearance to the mucin secretion induced experimentally with vitamin A in chickens and some mammals (Lawrence & Bern 1960, Jackson & Fell 1963, Sweeny & Hardy 1976. Mucinous metaplasia was present in the apocrine glands of 61 of the 100 samples of normal skin studied by Winkelmann & Hultin (1958).…”

The Action of Excess of Vitamin a Alcohol on the Fine Structure of Rat Dermal Fibroblasts

“…Similarly, the mitochondria in the cultured fibroblasts only begin to show signs of damage after approximately 9 hr treatment, while in buffered saline the initial changes appear in a few minutes and swelling is complete in 10 min (Dingle et el., 1962;Lucy, 1964). Mitochondria isolated from rat liver and kidney begin to swell almost immediately on treatment with low concentrations of retinol in sucrose (Lucy, Luscombe, and Dingle, 1963), while mitochondria in organ cultures of embryonic chick skin (Jackson and Fell, 1963) and mouse bone rudiments (Glauert and Fell, unpublished observations, see Fell, 1964) often take some days to show a similar degree of disorganization.…”