Epidermal dendritic cells. A quantitative study

Zelickson, Alvin S.

doi:10.1001/archderm.98.6.652

Cited by 30 publications

(19 citation statements)

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“…The smooth undulated cell membrane shows some prolonged cyto plasmic projections. This cell type fits in with the so-called indeterminate dendritic cells as described by Zelickson and Mottaz [45].…”

Section: Electron Microscopysupporting

confidence: 82%

“…In contrast to the lymphoid cells, the heterochromatin is quite regularly distributed and not condensed at the nuclear membrane. These cells are known in the literature for a long time and have been called 'indeterminate epidermal dendritic cells' or 'indeterminate cells' by Zelickson andMotiaz [45]. A few Langerhans' cells could also be identified in the infiltrated area of the epidermis [44].…”

Section: Discussionmentioning

confidence: 99%

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Microenvironment of Woringer-Kolopp’s Disease

1982

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A localized form of ‘Pagetoid reticulosis’ (Woringer-Kolopp’s disease) is described morphologically. It can be shown that ultrastructurally the ‘Pagetoid cells’ are heterogenic and that different cell types can be distinguished: there are lymphoid cells, which often look like Lutzner cells, and nonlymphoid cells which can be characterized as indeterminate cells or Langerhans’ cells. Often a close topographical relation between lymphoid and nonlymphoid cells can be demonstrated. This finding is suggestive for a functional interaction between the lymphoid cells, which are most probably T cells, and indeterminate cells and Langerhans’ cells, which are known to be important for the thymus-dependent immune reaction. The presence of the nonlymphoid cell population in the epidermis in Woringer-Kolopp’s disease seems to build up the specific microenvironment for lymphoid cell reaction.

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Section: Electron Microscopysupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Microenvironment of Woringer-Kolopp’s Disease

1982

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“…If these are'all positive in a large number of the infiltrating cells, it is very likely that the tumor under study represents Langerhans cell histiocytosis or indeterminate cell histiocytosis. Differentiation between these two further requires electron microscopy to identify the presence of Birbeck's granules in the former and the absence of the same in the latter (1). We report six infant and two adult cases of postscabetic nodules in which indeterminate cells were rich in the epidermis and dermis.…”

Section: Introductionmentioning

confidence: 91%

Post‐Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells

Hashimoto

Fujiwara

Punwaney

et al. 2000

The Journal of Dermatology

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We studied six infants and two adult cases of nodular scabies with immunostains and electron microscopy. All eight cases have had either direct (KOH) or family histories of scabies and were treated with lindane 1% cream or permethrin 5% cream. Family members responded very well, but our patients developed multiple papulo-nodular lesions which were initially very pruritic and, in some cases, persisted from several months to over one year. H & E stain of biopsied tissue sections revealed a heavy perivascular and periappendageal lymphohistiocytic cell infiltration. Immunophenotype of these cells was compatible with Langerhans cells, i.e. CD1A (+), S-100 (+) and HLA-DR (+). Electron microscopy showed that these histiocytic cells satisfied all the ultrastructural criteria of Langerhans cells except for the absence of Birbeck's granules. Lag, a monoclonal antibody for Birbeck's granules, was negative. "Persistent nodules in scabies" or "nodular scabies" seems to represent a prolonged response of indeterminate cells-lymphocytes to mite antigens.

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“…In the epidermis there are cells which ultrastructurally resemble Langerhans cells but lack Birbeck's granules (47). These cells were first and correctly regarded as related to Langerhans cells and later shown to possess CD1 epitope (48).…”

Section: A Indeterminate Cell Histiocytosismentioning

confidence: 99%

Current Topics of Immunohistochemistry as Applied to Skin Tumors

Hashimoto

Fujiwara

Mehregan

1993

The Journal of Dermatology

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Suppressor oncogene p53 is expressed more frequently in the nodular portion than the superficial spreading portion of the same melanoma. PCNA expression follows the same pattern but it is strongly expressed already in the superficial spreading portion. CD34 is found to label dermatofibrosarcoma protuberans. There is the mixture of negative strands but the immunostains are predominantly positive in the three cases studied. Neurogenic tumors are reactive but the intensity of staining is only moderate. Fibrous histiocytoma, dermatofibroma and other fibrohistiocytic tumors are non-reactive. CD34 is expressed in the outer root sheath of hair follicle below the sebaceous gland level. A case of piloepidermal cyst is CD34 positive. CD34 is expressed in vascular endothelial cells; not only hemangiomas but also lymphangiosarcoma is CD34 positive. A case of indeterminate cell histiocytosis following scabies and superficial variant of clear cell sarcoma are discussed as examples of new entities.

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Epidermal dendritic cells. A quantitative study

Cited by 30 publications

References 0 publications

Microenvironment of Woringer-Kolopp’s Disease

Microenvironment of Woringer-Kolopp’s Disease

Post‐Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells

Current Topics of Immunohistochemistry as Applied to Skin Tumors

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