Epidermal and dermal cells from adult rat eccrine sweat gland-containing skin can reconstruct the three-dimensional structure of eccrine sweat glands

Wang, Cangyu; Cao, Manxiu; Zhao, Junhong; Hu, Anqi; Liu, Xiang; Chen, Zihua; Zhang, Cuiping; Li, Haihong

doi:10.1016/j.acthis.2023.152120

Acta Histochemica

2024

DOI: 10.1016/j.acthis.2023.152120

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Epidermal and dermal cells from adult rat eccrine sweat gland-containing skin can reconstruct the three-dimensional structure of eccrine sweat glands

Cangyu Wang,

Manxiu Cao,

Junhong Zhao

et al.

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Dextran‐Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels

Liang,

Ling,

Sun

et al. 2024

Adv Healthcare Materials

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Infected wounds pose challenges such as exudate management, bacterial infections, and persistent inflammation, making them a significant challenge for modern dressings. To address these issues in infected wounds more effectively, we have developed aerogel‐hydrogel biphase gels (AHB‐gel) based on Dextran (Dex). The gel introduced in this study exhibits antibacterial and anti‐inflammatory properties in the process of wound therapy, contributing to accelerate wound healing. The aerogel phase exhibits exceptional water‐absorption capabilities, rapidly soaking up exudate from infected wound, thereby fostering a clean and hygienic wound healing microenvironment. Concurrently, the aerogel phase is enriched with hydrogen sulfide donors. Following water absorption and the formation of the hydrogel phase, it enables the sustained release of hydrogen sulfide around the wound sites. The experiments confirmed that hydrogen sulfide, by promoting M2 macrophage differentiation and reducing the levels of inflammatory factors IL‐6 and TNF‐α, effectively diminishes local inflammation levels at the wound site. Furthermore, the sodium copper chlorophyllin (SCC) component within the hydrogel phase demonstrates effective antibacterial properties through photodynamic antimicrobial therapy (PAT), providing a viable solution to wound infection challenges.This article is protected by copyright. All rights reserved

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Dextran‐Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels

Liang,

Ling,

Sun

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

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Epidermal and dermal cells from adult rat eccrine sweat gland-containing skin can reconstruct the three-dimensional structure of eccrine sweat glands

Cited by 1 publication

References 29 publications

Dextran‐Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels

Dextran‐Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels

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