Epidemiology, Risk Factors, Prevention, and Early Detection of Melanoma

Azoury, Saïd C.; Lange, Julie R.

doi:10.1016/j.suc.2014.07.013

Cited by 107 publications

(70 citation statements)

References 104 publications

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“…It is estimated that more than seventy thousand melanoma cases were diagnosed in 2014 in the United States (2) and is still rapidly increasing compared to any other solid tumors (3). Over the past years, some progress has been made in surgery removal, chemotherapy and radiotherapy (4,5).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT

Ding

Hong

et al. 2016

BST

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT

Ding

Hong

et al. 2016

BST

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“…Interestingly, NPS-2143 provoked a strong inhibition of cell proliferation by inducing the apoptosis of these melanoma cells. Melanoma, which is the most aggressive type of skin cancer, has become more common since the 1960s in areas which are mostly populated with white people, both men and women [4,11]. In 2015, newly occurred melanoma cases reached 3.1 million and 59,800 deaths were recorded [4,28,29].…”

Section: Discussionmentioning

confidence: 99%

NPS - 2143 (hydrochloride) inhibits melanoma cancer cell proliferation and induces autophagy and apoptosis

2018

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> Melanoma is a common and aggressive skin cancer caused by the oncogenic transformation of melanocytes. NPS-2143 (hydrochloride) is a calcification drug that acts as an antagonist of the calcium-sensing receptor (CaSR) and consequently stimulates the release of parathyroid hormone. In the present work, we treated cells from the human melanoma cell line M14 to investigate the effects of NPS-2143 on melanoma cells and elucidate their underlying mechanisms. We observed that NPS-2143 inhibits the survival and proliferation of M14 cells and suppresses the migration and proliferation of M14 cells by inducing apoptosis. The Bax/Bcl-2 ratio in M14 cells was enhanced by the NPS-2143 treatment, suggesting that the mitochondrial apoptotic pathway was activated. The expression and phosphorylation of proteins involved in the PI3K signaling pathway were altered by NPS-2143 treatment. Our data show that NPS-2143 impacts the viability and induces the apoptosis of melanoma M14 cells through its impact on the PI3K signaling pathway. It suggests that NPS-2143 could represent a promising candidate for melanoma treatment. <

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“…As the incidence of melanoma has increased over the past few decades, patient education on early detection, heritability, and modifiable risk factors is critical [3]. Comprehending the complex development of malignancy, clinical and pathologic diagnosis, and subsequent management strategies for melanoma can be difficult.…”

Section: Introductionmentioning

confidence: 99%

Readability of online patient resources for melanoma

Ibrahim

Vargas²,

Koolen³

et al. 2016

Melanoma Research

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Medical information is often difficult for patients to understand. With specialized vocabulary and complex pathophysiology, even well-educated adults have trouble interpreting information about their healthcare. The average American adult reads at a seventh-grade level. In light of the inherent complexity of health information, the American Medical Association and National Institutes of Health have recommended that information for patients should be written at a sixth-grade level. The goal of this study was to evaluate the most commonly used online patient resources about melanoma in the context of these recommendations. A web search for 'melanoma' identified the 10 most-accessed websites. Location filters were disabled and sponsored results were excluded to avoid inadvertent search bias. All relevant, patient-directed articles were downloaded and formatted into plain text. Pictures, videos, links, advertisements, and references were removed. Readability analysis was carried out using 10 established tests, both overall and arranged by parent website for comparison. A total of 130 articles for melanoma information were identified. The overall mean reading grade level was 12.6. All sites exceeded the recommended sixth-grade level. Secondary analysis of articles grouped by website indicated a range of readability across sites from 9.9 (high school freshman) to 14.9 (university sophomore). Online patient resources for melanoma uniformly exceed the recommended reading level and may be too difficult for many Americans to understand. The range of readability among websites may indicate an opportunity for physicians to direct patients to more appropriate resources for their level of health literacy.

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Epidemiology, Risk Factors, Prevention, and Early Detection of Melanoma

Cited by 107 publications

References 104 publications

RETRACTED: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT

RETRACTED: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT

NPS - 2143 (hydrochloride) inhibits melanoma cancer cell proliferation and induces autophagy and apoptosis

Readability of online patient resources for melanoma

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