Epidemiology research to foster improvement in chronic kidney disease care

Luo, Shengyuan; Grams, Morgan E.

doi:10.1016/j.kint.2019.11.010

Cited by 16 publications

(16 citation statements)

References 130 publications

(142 reference statements)

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“…AKI is established as a rise of creatinine level in the blood about 0.3 mg/dl in less than 48 h and increased to 1.5 times in less than 7 days, and urine volume of 0.5 ml/kg/h is more than 6 h. Hypovolemia and urinary blockage, drug poisoning is the most common causes. A determined irregularity of structure and function of the kidney (e.g., albuminuria >30 mg per 24 h or glomerular filtration rate (GFR) 60 ml/min/1.73 m 2 ) for more than 3 months is characterized as CKD ( Luo and Grams, 2020 ). The most prevalent causes of CKD include diabetes, hypertension, and primary glomerular disease.…”

Section: Introductionmentioning

confidence: 99%

“…In terms of definition, causation, and treatment approaches, they are very different. CKD is a global health concern that affects more than 10% of the population, with a higher prevalence among the elderly ( Luo and Grams, 2020 ). Patients with CKD usually endure a slew of problems and negative outcomes, putting a significant financial strain on both the people affected and society as a whole ( Saran et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

Merlin

2022

Front. Genet.

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Nanoparticles (NPs) are differing in particle size, charge, shape, and compatibility of targeting ligands, which are linked to improved pharmacologic characteristics, targetability, and bioavailability. Researchers are now tasked with developing a solution for enhanced renal treatment that is free of side effects and delivers the medicine to the active spot. A growing number of nano-based medication delivery devices are being used to treat renal disorders. Kidney disease management and treatment are currently causing a substantial global burden. Renal problems are multistep processes involving the accumulation of a wide range of molecular and genetic alterations that have been related to a variety of kidney diseases. Renal filtration is a key channel for drug elimination in the kidney, as well as a burgeoning topic of nanomedicine. Although the use of nanotechnology in the treatment of renal illnesses is still in its early phases, it offers a lot of potentials. In this review, we summarized the properties of the kidney and characteristics of drug delivery systems, which affect a drug’s ability should focus on the kidney and highlight the possibilities, problems, and opportunities.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

Merlin

2022

Front. Genet.

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“…The lack of disease specific information means that users will not understand the relationship between regular and adequate hydration and good kidney health. As incidence of urological diseases increase [ 5 , 6 ], it is important for users to maintain their hydration regularly.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of kidney-related diseases is also rising. The incidence of both chronic kidney disease and kidney stone disease (KSD) are steadily increasing [ 5 , 6 ]. It is estimated that 12% of the world population is now affected by KSD, thereby further increasing the risk of CKD and end-stage renal failure [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

A content analysis of 'Water Apps' and prevention of urological diseases: Do apps really help?

2020

Cent european J Urol

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Introduction Maintaining hydration reduces incidence of kidney stone disease (KSD), chronic kidney disease (CKD) and urinary tract infections (UTIs). Mobile applications (apps) measuring hydration are gaining in usage, allowing users to monitor intake whilst also taking into account the signs and symptoms of dehydration. Our study looked at the water apps in the management and/or prevention of urological disease. Material and methods The original android app store (Google Play Store), and the Apple App Store (iOS App Store) were searched using the term ‘hydration’, ‘fluid’ and ‘water’. All apps from each distribution platform, with a minimum of 100 reviews, were then selected and analysed. Results After identification of 51 applications (13 from Apple App Store, and 38 from Google Play Store), 45 were free to download and 6 were paid (cost range: $2.19–$7.97). While none of the apps facilitated measurement of urine output and colour, 12 mentioned signs and symptoms of dehydration. Furthermore, when calculating required fluid intake, the level of activity was considered by 31 apps. With regards to information provision, only one of the apps included advice or education about urological conditions associated with poor hydration. None of the apps gave advice on hydration related to CKD and UTI. Conclusions Mobile phone apps are a well-established tool for measuring fluid intake. However, they provide little information regarding the importance of hydration, and don’t utilise other measures such as level of activity, urine output or colour. Considering the increasing popularity of fitness and hydration apps in our daily lives, the developers need to make them more comprehensive and informative.

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“…Важливим є пріоритетний розподіл ресурсів охорони здоров'я в країнах з достатнім рівнем доходів -на раннє визначення нових випадків ХХН, а в країнах з низьким та середнім рівнем -на покращення терапевтичного супроводу вже відомих випадків [16,17]. В той же час дані щодо епідеміології педіатричної ХХН визнані недостатніми не тільки для регіонів з обмеженими ресурсами, але й для технологічно розвинутих країн з широкими науковими та фінансовими можливостями [18,19]. Прийнято, що ситуація в педіатричній нефрології по розповсюдженості та захворюваності в цілому повторює профілі та тренди хворих віком після 18-ти років [1-3, 18, 19].…”

Section: таблицяunclassified

Chronic kidney disease in children in Ukraine

Fomina

2021

Ukr. J. Nephrol. and Dial.

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The study aimed to summarize data of Chronic Kidney Disease (CKD) in children and adolescents in Ukraine. Methods. There were performed a qualitative study based on published documents and registers, and a cohort observational study included 3528 depersonalized patients with CKD diagnosed before the age of 18. That was used cross-sectional and longitudinal design for the structure, etiology, and outcomes analysis, period comparison (years 2014 and 2019), quantitative analyzes depending on patients age and nosology, risk measurements and survival function. Results. There was found the tendency to reduce the incidence of the genitourinary system diseases in childhood, and the predominance of these classes of diseases in adolescents. The main causes of CKD were congenital structural or histological abnormalities and glomerulonephritis. Prolonged kidney function preservation at the initial level was confirmed in many patients (CKD1 was maintained in 33.0% and CKD5 - in 56.6% causes after 5 years period) with the partial function improvement in CKD1-3. CKD1-4 probability at the 1st year of observation was 91.7±0.47%, at the 5th year - 84.2±0.82%. The structural CKD5 specialties in patients receiving Kidney Replacement Therapy have been established. There was a significantly higher risk of CKD5 during 5 years period after Acute Kidney Injury (OR 2.81-2.10), and a lower probability of CKD5 in patients with glomerulonephritis (OR 0.66-0.54) compared to other nosology. CKD pathomorphosis was found in the year 2019 compared to the year 2014: the kidney dysplasia as an etiological factor was increased (from 19.3% to 22.0%, р=0.040); the immediate outcome at the 1st year of observation was improved with the lower risk of declaring of Glomerular Filtration Rate (GFR) to CKD5 level (93.6% vs. 90.0%), but the late follow-up prognosis became worse (the cumulative probability of CKD1-4 at the 5th year of observation decreased from 85.5 to 73.9%, p=0.016); the structure of Kidney Replacement Therapy changed with the increasing part of transplanted patients (from 30.5% to 48.9%, p<0.001), especially as a first choice (pre-dialysis); the tendency to decrease the proportion of polycystic kidney disease in CKD and to increase it in CKD5 was revealed with risk raising of GFR loss <15 ml/min in the year 2019 compared to other nosology (OR 1.69, p=0.027). Conclusions. The established epidemiological and clinical realities are important for determining the kidney disease outcome in children and adolescents, assessing the medical management of these patients, sharpening the priorities of pediatric nephrology, and emphasizing the significance of further studies with appropriate regulations.

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Epidemiology research to foster improvement in chronic kidney disease care

Cited by 16 publications

References 130 publications

Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

A content analysis of 'Water Apps' and prevention of urological diseases: Do apps really help?

Chronic kidney disease in children in Ukraine

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