Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis

Satoskar, Anjali A.; Parikh, Samir; Nádasdy, Tibor

doi:10.1038/s41581-019-0178-8

Cited by 111 publications

(159 citation statements)

References 129 publications

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“…Clinically, kidney injury caused by bacterial infection is more common than that caused by viral infection and streptococcal glomerulonephritis was the most typical. 13 The constituent percentage of the patients with bacterial infection in the control group was probably higher than that in the COVID-19 group, which might also be the reason that the mean levels of urea and creatinine in the control patients were significantly higher than those in COVID-19 patients. Furthermore, patients with COVID-19 more frequently had decreased or normal urea and creatinine compared than control patients.…”

Section: Discussionmentioning

confidence: 89%

Differences between COVID‐19 and suspected then confirmed SARS‐CoV‐2‐negative pneumonia: A retrospective study from a single center

Chen

Yang

Huang

et al. 2020

Journal of Medical Virology

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Coronavirus disease 2019 (COVID‐19) broke out in Wuhan, Hubei, China in December 2019. Tens thousands of people have been infected with the disease. Our aim was to distinguish severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐positive patients from SARS‐CoV‐2‐negative patients. We retrospectively compared the data of COVID‐19 patients with those of suspected and confirmed SARS‐CoV‐2‐negative patients (control patients). There were 78 COVID‐19 patients and 26 control patients, whose median ages were significantly different (P = .001). The percentage of COVID‐19 patients admitting exposure to Wuhan was obviously higher than that of control patients (X2 = 29.130; P < .001). Fever and cough appeared more frequently in COVID‐19 patients than in the control patients. The routine blood workup parameters of COVID‐19 patients did not change much and their mean counts were in the normal range. There were 38.5% of control patients had higher procalcitonin (PCT) levels than 0.5 ng/mL, which was significantly higher than that percentage of COVID‐19 patients (X2 = 22.636; P < .05), and COVID‐19 patients were also more likely to have decreased or normal urea and creatinine levels than control patients (X2 = 24.930, 8.480; P < .05).Younger age, exposure to Wuhan, fever, cough, and slight changes in routine blood workup parameters, urea and creatinine were important features discriminating COVID‐19 from control patients. Slightly increased, but far less than 0.5 ng/mL, PCT levels also differentiated COVID‐19 patients from control patients.

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Section: Discussionmentioning

confidence: 89%

Differences between COVID‐19 and suspected then confirmed SARS‐CoV‐2‐negative pneumonia: A retrospective study from a single center

Chen

Yang

Huang

et al. 2020

Journal of Medical Virology

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“…For example, glomerulonephritis (GN) can develop following streptococcal upper respiratory tract or skin infections with a latent period of approximately 10 days. As streptococcal infections are usually cured when GN is diagnosed and there is a distinct infection-free latent period, the GN has been referred to as poststreptococcal acute glomerulonephritis (PSAGN) [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…In previous years, most cases of AGN were PSAGN in children; however, probably owing to the improvement of living environments and the adequate usage of antibiotics, the incidence of PSAGN has been decreasing, particularly in developed countries [4]. Whereas PSAGN is still the most common cause of pediatric AGN, adult AGN cases have been increasing, and those associated with non-streptococcal infections, particularly infections by Staphylococcus aureus, are now as common as PSAGN [5].…”

Section: Introductionmentioning

confidence: 99%

Glomerular Deposition of Nephritis-Associated Plasmin Receptor (NAPlr) and Related Plasmin Activity: Key Diagnostic Biomarkers of Bacterial Infection-related Glomerulonephritis

Uchida

Oda

2020

IJMS

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It is widely known that glomerulonephritis (GN) often develops after the curing of an infection, a typical example of which is GN in children following streptococcal infections (poststreptococcal acute glomerulonephritis; PSAGN). On the other hand, the term “infection-related glomerulonephritis (IRGN)” has recently been proposed, because infections are usually ongoing at the time of GN onset in adult patients, particularly in older patients with comorbidities. However, there has been no specific diagnostic biomarker for IRGN, and diagnosis is based on the collection of several clinical and pathological findings and the exclusion of differential diagnoses. Nephritis-associated plasmin receptor (NAPlr) was originally isolated from the cytoplasmic fraction of group A streptococcus as a candidate nephritogenic protein for PSAGN and was found to be the same molecule as streptococcal glyceraldehyde-3-phosphate dehydrogenase and plasmin receptor. NAPlr deposition and related plasmin activity were observed with a similar distribution pattern in the glomeruli of patients with PSAGN. However, glomerular NAPlr deposition and plasmin activity could be observed not only in patients with PSAGN but also in patients with other glomerular diseases, in whom a preceding streptococcal infection was suggested. Furthermore, such glomerular staining patterns have been demonstrated in patients with IRGN induced by bacteria other than streptococci. This review discusses the recent advances in our understanding of the pathogenesis of bacterial IRGN, which is characterized by NAPlr and plasmin as key biomarkers.

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“…Acute kidney injury in the setting of infection can be multifactorial and difficult to differentiate. Although infection-related glomerulonephritis is a known cause, it is uncommon with a prevalence of 0.8% [1]. Staphylococcus associated glomerulonephritis is on the rise due to change in patient demographics and increasing incidence of community acquired methicillin resistant Staphylococcus aureus.…”

Section: Introductionmentioning

confidence: 99%

“…Staphylococcus associated glomerulonephritis is on the rise due to change in patient demographics and increasing incidence of community acquired methicillin resistant Staphylococcus aureus. SAGN mainly affects older adult males and its incidence peaks between the fifth and seventh decades of life [1] [2]. Prevalence of drug induced interstitial nephritis is also on the rise due to widespread use of antibiotics [3].…”

Section: Introductionmentioning

confidence: 99%

A Case of Staphylococcus Associated Glomerulonephritis Confused with Acute Interstitial Nephritis

Ratnayake¹,

Teo²

2020

CRCM

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Staphylococcus associated glomerulonephritis (SAGN) is an uncommon infection-related glomerulonephritis. Although infection is typically ongoing when patients present with SAGN, in the case of deep-seated infections, the presence of infection may not be apparent. The aim of this study is to highlight the importance of renal biopsy when the diagnosis is not obvious. We present a case of staphylococcus associated glomerulonephritis in a patient treated with beta-lactam antibiotics for staphylococcus bacteraemia. A renal biopsy helped differentiate between interstitial nephritis and staphylococcus associated glomerulonephritis.

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Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis

Cited by 111 publications

References 129 publications

Differences between COVID‐19 and suspected then confirmed SARS‐CoV‐2‐negative pneumonia: A retrospective study from a single center

Differences between COVID‐19 and suspected then confirmed SARS‐CoV‐2‐negative pneumonia: A retrospective study from a single center

Glomerular Deposition of Nephritis-Associated Plasmin Receptor (NAPlr) and Related Plasmin Activity: Key Diagnostic Biomarkers of Bacterial Infection-related Glomerulonephritis

A Case of Staphylococcus Associated Glomerulonephritis Confused with Acute Interstitial Nephritis

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