Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey

Akay, Bengü Nisa; Bozkir, Mehtap; Anadolu, Y; Güllü, Sevim

doi:10.1111/j.1468-3083.2010.03605.x

Cited by 88 publications

(114 citation statements)

References 45 publications

(150 reference statements)

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“…In our study, the positivity of thyroid autoantibody was detected in 20.6% of the vitiligo group, similar to the literature. In another study from Turkey, the incidences of alopecia areata and chronic urticaria in patients with vitiligo were 12.5% and 2.5%, respectively, and family history was found in 27.5% (29). In our study, the rates of alopecia areata and chronic urticaria were found to be 2.7% and 5.5%, respectively.…”

Section: Discussionsupporting

confidence: 56%

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

Rifaioğlu¹,

Aydogan²,

Şen³

et al. 2014

Turk J Med Sci

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IntroductionVitiligo is an acquired depigmenting skin disorder. It occurs clinically by the appearance of well-circumscribed, asymptomatic, white macules following the loss of functional melanocytes in the epidermis (1). The prevalence rate of vitiligo ranges from 0.06% to 2.28% in the population (2). The main etiopathogenesis of vitiligo is multifactorial. According to various pathophysiological theories, it may be associated with autoimmunity, neurogenic dysregulation, autocytotoxicity, biochemical dysregulation, oxidative stress, and weak melanocyte viability (1,(3)(4)(5)(6). Several potentially environmental factors such as infectious agents appear to be related with vitiligo (7-9).Helicobacter pylori (HP) is a major health problem affecting about 50% of the world population (10). Gastric ulceration and carcinogenesis are associated with HP infection (11). HP infection has been linked to various autoimmune dermatological diseases, such as alopecia areata, Behçet's disease, chronic urticaria, pruritus, psoriasis, and rosacea (12-17). The frequency of HP has not been studied in patients with vitiligo. Noninvasive tests such as the carbon 13 or carbon 14 (C14) urea breath test (UBT), stool antigen tests, and serology are used to detect HP infection (18). In this study, we used the C14 UBT to detect the frequency of HP infection in patients with vitiligo. Materials and methods Patient and control groupsWith the approval of the local ethics committee, a prospective study was conducted in our dermatology department clinic. The study comprised 34 patients with vitiligo and 30 age-and sex-matched healthy controls. The patients with vitiligo were newly diagnosed and older than 16 years. The patients with gastrointestinal symptoms or those who had received eradication therapy for HP earlier were excluded from the study. Other exclusion criteria were age under 16 years, pregnancy or lactation, and the use of antibiotics, proton pump inhibitors, or H2 blockers in the 40, 7, and 14 days, respectively, leading up to sample collection. According to the working clinical classification, vitiligo was classified as vitiligo vulgaris, acrofacial, focal, segmental, universal, or mucosal (16).Background/aim: Vitiligo is a common, acquired depigmenting skin disorder. The relationship between Helicobacter pylori (HP) infection and autoimmune dermatological disease has been previously reported. However, the frequency of HP infection in patients with vitiligo has not been reported. In this study, we aimed to investigate the frequency of HP infection with the carbon 14 (C14) urea breath test (UBT) in patients with vitiligo. Materials and methods:This study included 34 patients (18 males and 16 females) with vitiligo and 30 age-and sex-matched healthy controls. HP infection was diagnosed using the C14 UBT (Heliprobe). Statistical analysis was performed using SPSS 19. Results:The frequency of HP infection was 64.7% in the patient group and 33.3% in the control group according to the C14 UBT (chisquare test, P = 0.012). HP infection frequ...

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Section: Discussionsupporting

confidence: 56%

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

Rifaioğlu¹,

Aydogan²,

Şen³

et al. 2014

Turk J Med Sci

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“…This result can be due to the destruction of melanocytes in the inner ear which have multiple roles critical for hair cell survival, including maintenance of the normal function of the stria vascularis and the cochlea, the development of endocochlear potentials and ion and fluid gradient between the endolymph and perilymph. In studies on this theme, the evaluation of hearing revealed similar results, i.e., decreased hearing at high frequencies [16][17][18]. Ardiç et al [18] explained that Vitiligo seems to be an effective factor in hearing loss and that the mechanism for this condition might be absence of the preventive function of melanocytes in the inner ear.…”

Section: Discussionmentioning

confidence: 88%

Audiological and Electrophysiological Changes in Patients with Vitiligo

Arya

Munjal

Panda

et al. 2015

Indian J Otolaryngol Head Neck Surg

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The study was conducted to evaluate the audiological and electrophysiological findings in patients with Vitiligo and to compare the findings with otologically and audiologically normal controls. Study group included 50 subjects (25 Males, 25 Females) with Vitiligo (Mean age-27.4 years) and control group contained 40 age-matched normal hearing subjects. Pure tone audiometry (PTA) with extended high frequency audiometry, Otoacoustic emissions (OAEs), Tympanometry, Auditory brainstem responses (ABR) and Middle latency responses (MLR) were conducted in all subjects. Comparison of the study group with the control group showed statistically significant differences (p \ 0.05) on PTA, in Transient otoacoustic emissions (TOAEs) at 1, 2, 3, 4 kHz and in distortion product otoacoustic emissions (DPOAEs) at 357, 499, 704, 1003 Hz. On ABR, statistically significant differences were observed between the groups in wave I (p \ 0.01) in both ears, wave V (p \ 0.05) in left ear and on interpeak latency of I-III (p \ 0.01, p \ 0.05), III-V (p \ 0.01 in left ear) and I-V (p \ 0.01, p \ 0.05) in left and right ears respectively. When patients with localized vitiligo were compared with generalized vitiligo, the SNR of TOAEs was highly significant in both ears at 2 KHz (p \ 0.05), 3 kHz (p \ 0.01) and 4 kHz (p \ 0.05). PTA average of 2 KHz, 4 and 8 kHz (PTA2) showed a significant difference (p \ 0.01) when localized vitiligo was compared to generalized vitiligo. Results support possible auditory and electrophysiological changes in Vitiligo patients along with decreased cochlear function.

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“…9 Association of acoustic abnormalities with certain hypopigmentary disorders like Wardenburg's syndrome, albinism, Alzendrini syndrome and Vogt-Koyanagi-Harada syndrome has been described. 10 White and black skinned individuals differ in levels of noise induced hypoacusis, owing to the quantitative differences in pigment cells in inner ear. 11 Acoustic abnormalities in vitiligo patients remain obscured for long durations.…”

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confidence: 99%

Vitiligo associated hypoacusis: a case control study

Maheshwari

Panigrahi

Mahajan

2016

Int J Otorhinolaryngol Head Neck Surg

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Background: Vitiligo is a progressive depigmenting cutaneous disorder, resulting from the loss of melanocytes. In the inner ear, melanocytes are believed to play an important role in development and normal functioning of stria vascularis. Acoustic abnormalities in vitiligo patients remain obscured for long durations. This study was carried out to determine the prevalence of subclinical sensorineural hearing loss in vitiligo patients, if any, in comparison with controls and to detect any relevant demographic or clinical finding characteristic of hypoacusis in vitiligo patients.Methods: A prospective case control study was undertaken in 50 vitiligo patients (case group), who were compared with another 50 age and sex matched healthy volunteers (control group). All cases underwent detailed dermatological and ENT examination and were subjected to tests like pure tone audiometry, transient evoked otoacoustic emission (TEOAE).Results: A statistically significant (p value = 0.039), higher average pure tone hearing threshold (APT-HT) was noted in vitiligo patients in comparison with the control group. Vitiligo originating at the head and neck was strongly associated with hypoacusis (54.55%, 6 of 11 cases). TEOAE reproducibility % was reduced to 42.6% in the vitiligo group.Conclusion: Vitiligo is associated with subclinical sensorineural hypoacusis. Vitiligo with its primary site in head and neck region and co-exixting leucotrichia shows a strong association with asymptomatic sensorineural hypoacusis in such patients. Pure tone audiometery and TEOAE can be effectively used to assess and follow up vitiligo patients for asymptomatic subclinical sensorineural hypoacusis.

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Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey

Abstract: Our study demonstrates that vitiligo is a part of systemic autoimmune process. Audiological examination should be performed in all patients for auditory problems which are commonly presented as hypoacusis.

Cited by 88 publications

References 45 publications

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

Audiological and Electrophysiological Changes in Patients with Vitiligo

Vitiligo associated hypoacusis: a case control study

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